Báo cáo y học: "Understanding genetics of sepsis: will new technology help" pot

... conclusion, new technology such as GWAS has the potential to improve our understanding of genetics of sepsis. Large studies will have to be conducted, however, to effectively utilize this technology. ... Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney ASF, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Giannin...

Ngày tải lên: 13/08/2014, 15:21

... improvement by using objective information to analyse and improve systems and service delivery [7]. Participating services use annual quality improvement cycles (plan-do-study-act) and a set of clinical ... attributes of the inno- vation and the change agency within which it sits; the process of diffusion or dissemination; elements of the user system; and in the outer system context....

Ngày tải lên: 11/08/2014, 05:21

... Another of the stated goals of the Campaign, and one that directly addresses an issue identified by the survey, is to raise public awareness of sepsis as a common and deadly disease in critically ill ... management through the implementation of guidelines to create a global standard of care for sepsis, thereby reducing mortality from sepsis by 25% over 5 years. An unprecedented 11 o...

Ngày tải lên: 12/08/2014, 20:20

Ngày tải lên: 13/08/2014, 10:20

... timely fashion may progress rapidly from infection to septic shock [2]; an older patient may be more likely to die than a younger, healthier patient with the same illness [3]. Many a physician, however, ... altered level of risk of developing acute lung injury/acute respiratory distress syndrome, or positive associations with clinical outcomes [1]. They then sought to evaluate the quality...

Ngày tải lên: 13/08/2014, 11:23

... which “ data collected by one researcher are re-analysed by another investigator usually to test new research hypoth- eses” [28]. Thus secondary analysis uses data which have already been collected ... one of the indicators of the MDG 5-delivery attendance by skilled personnel increased by 9% against the reference year, which needs to b e increased by 49% in order to achieve the MDG tar...

Ngày tải lên: 13/08/2014, 15:21

... sepsis, is often listed as the underlying cause of death. Consequently, analy- ses restricted only to decedents with sepsis listed as the underlying cause of death will significantly underestimate ... employed in standardisation and calculation of age-specific rates and ratios were: less than 1 year, 1 to 4 years, 5 to 14 years, 15 to 24 years, 25 to 34 years, 35 to 44 years, 45 to 54...

Ngày tải lên: 13/08/2014, 15:22

... of the relative rates of synonymous and non-synonymous base substitutions would also allow the detection of diversifying selection (if there was selection to alter the structure of proteins of ... same cell type or entirely different cell types in the case of biphasic neoplasms. Mathematically, this can be described by the equations dx/dt = r 1 x (1-bx-cy) and dy/dt = r 2 y (1-f...

Ngày tải lên: 13/08/2014, 16:20

... expression of type I IFNs, a major component of antiviral immunity [44]. TLR9 signalling through MyD88 by plasmacytoid dendritic cells can also produce high amounts of type I IFNs upon recognition of bound ... immunodeficiency rather than autoimmune syndromes [40], although a recent linkage analysis study of 44 single nucleotide polymorphisms in 13 genes from the type I IFN pathway...

Ngày tải lên: 09/08/2014, 07:20

... generally found closely associated with T lymphocytes [16,90,93], which may signal the alternate NF-κB pathway through proinflammatory cytokines, CD154 (CD40L) and lymphotoxin-β [111,112]. Synthesis: ... immunomodulatory effect of TNF blockade in RA relates in part to reduction of traffic of DC and other immunocytes to the inflammatory site [107]. Increased numbers of myeloid and plas...

Ngày tải lên: 09/08/2014, 10:20