... microarray
data
Relationships between gene expression variables are very
complex and patterns that have clinical significance may
take many forms. It is likely that combinations of variables
that ... peripheral blood offers many advantages as a
source of analysis material, one potential drawback is the
small quantities of RNA that can be reasonably obtained.
Surprisingly, information ab...
... This paw was designated as acute
arthritic (AA), and contralateral or ipsilateral paws that were
Arthritis Research & Therapy Vol 7 No 2 Adarichev et al.
R199
with cartilage PG, and live lymphocytes ... normal paws of naive BALB/c
SCID
mice (AN), clinically normal
pre-arthritic paws (PA), acutely arthritic paws (AA) and chronically
inflamed paws (CA).
Available online http://arthriti...
... collagen-induced arthritis (CIA) is a chronic inflamma-
tory disease that bears all the hallmarks of rheumatoid arthritis
(RA), namely polyarthritis and synovitis with subsequent carti-
lage and ... the patella tendon was transversally cut and the prox-
imal and distal part carefully mobilized. After exposure, the
'Hoffa's fatty body' was superfused with 37°C warm physio-...
... (tetrasaccharides and hexasaccharides of
hyaluronate and heparan sulphate) [39-41]. Interestingly, all
known carbohydrate TLR ligands fall into the category of oli-
gosaccharides generated by endoglycosidases, ... SFs are key players in the
pathogenesis of RA by invading and eroding hyaline cartilage.
SFs, activated locally, produce a variety of cytokines, chemok-
ines and matrix-degrading...