Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt

... with surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integ- rity of the BBB [55-57]. In the present study, we found that, during experimental ... break-down of the BBB during experimental sepsis. • The C5aR is robustly upregulated in the pituitary gland during CLP-induced sepsis. • Pituitary mRNA expressio...

Ngày tải lên: 13/08/2014, 15:21

... pulmonary hypertension of the newborn due to cytokine elaboration, acidosis and hypoxia in the setting of sepsis [52]. These underlying differences in anatomy, physio- logy and adaptive cardiovascular ... confined to the blood compart- ment, however, while a hyperinflammatory state persists in tissues, which makes defining the role of cytokines in sepsis more difficu...

Ngày tải lên: 13/08/2014, 08:20

... then determined by using a cytokine protein array (TranSignal Mouse Cytokine Antibody Array 1.0; Panomics, Inc., Fremont, CA, USA) according to the manufacturer's instructions. Enzyme-linked ... TWEAK for 48 hours. The culture supernatants were then collected and subjected to a cytokine protein array. The table indicates the corre- sponding cytokines on the protein array memb...

Ngày tải lên: 09/08/2014, 08:22

... com- panying description/explanation) is created at the foot of the page. Clicking the button executes the URL, which takes a single parameter, the symmetrically encrypted primary-key value of the ... vocabularies. Finally, based on the study calendar, individual para- meters may only be recorded for the CRFs/time-points where they a pply. The ap proach of programming...

Ngày tải lên: 10/08/2014, 09:22

... wonder whether everybody in our ward know what they are reflecting, or what they mean, there is a day I tried study- ing one but and [Facilitator] does these charts in the Paeds ward, the MCH, and the ... with us and then may be in the end you can even make you will have seen how I was working. Like yesterday I heard the doctor saying 'they are always coming here, w...

Ngày tải lên: 11/08/2014, 05:21

... protein gp120 and has significant HIV-binding and inhibitory activities[3]. SP-D expression has recently been measured in both respiratory and non-respiratory mucosa including the oral cavity and ... 19 HIV-infected and 17 HIV-uninfected individuals, all of whom were healthy at the time of bron- choscopy and had a normal chest X ray. The demographic and clinical char...

Ngày tải lên: 12/08/2014, 15:20

... vasculature, thereby lowering the pulmonary capillary pressure and reducing fluid filtration in the lung [27]. It has been shown that the inhibition of NO production by L-nitro arginine methyl ester ... Uchida for statistical analysis and the US Army for providing the αα -hemoglobin used in this study. The study was per- formed at the Department of Anesthesiology, Un...

Ngày tải lên: 12/08/2014, 18:20

... resuscitation and requiring vaso- pressor therapy. The beginning of vasopressive therapy was considered the time of diagnosis of septic shock. Exclusion criteria were age of less than 18 years and the absence ... reduced cytokine synthesis (interferon-gamma (IFN-g)orIL-2orboth [21-24]). The co-inhibitory PD-1 system has been stu- died mainly in viral diseases and oncol...

Ngày tải lên: 14/08/2014, 08:21

... NAMI-A-mediated inhibition of ERK1/2 phosphorylation may be lying upstream of ERK1/2. Using a serine/threonine kinase SPA assay kit, the capability of NAMI-A to affect the ERK1/2 phosphoryla- tion activity ... maintenance of tumor cell growth [3]. The finding that the ERK signaling pathway is involved in tumor cell migration and invasion [4,5], as well as in tubular forma...

Ngày tải lên: 21/02/2014, 01:21

... glycoside, streptomycin, t he penicillins, ampicillin and penicillin G, the aminocyclitol, spectinomycin, tetracycline and Cl-tetracycline, and the macrolide, erythromycin) on n uclear b-globin ... described previously [31]. RESULTS Erythromycin, Cl-tetracycline and streptomycin inhibit nuclear splicing in vitro The effects of eight different antibiotics (the aminoglycoside...

Ngày tải lên: 21/02/2014, 15:20