... pathways,including amplifying the inflammatory process by inducing theextravasion of neutrophils and the production of IL-8, inducingan inflammatory reaction in the endothelia, and/or stimulatinglung ... Clinically, thedisease is very heterogeneous, ranging from limited skininvolvement with limited systemic alterations to clinical pic-tures with diffuse skin sclerosis and severe visceral involve-ment ... downregulated. In contrast,α1-acid glycoprotein, calumenin, cytohesin-2, haptoglobin-αchain, and calgranulin B were significantly upregulated, andthe expression of mtDNA TOP1 was observed only in SScFib+patients.On...