... Fedosov et al. Mapping of transcobalamin using antibodies FEBS Journal 272 (2005) 38873898 ê 2005 FEBS 3889 Mapping the functional domains of human transcobalamin using monoclonal antibodies Sergey ... on the functional activ- ity of TC. Arrows show the hypothetical movement of the domains after attachment of Cbl, see the main text. Mapping...
Ngày tải lên: 20/02/2014, 01:20
... PrP. Production of deletion mutants of PrP On the basis of the results with antibodies, a series of PrP mutants were made to assess whether deletions of certain domains of the protein decrease the SOD-like ... syndrome [6]. All of these disease are linked together because of the deposition of an abnormal, protease-resistant isoform of the prion protein in...
Ngày tải lên: 21/02/2014, 00:20
Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... Arg16 and Glu20. The biological impact of the Aib1 5 and D -Phe12 modifications on the synthetic CRH analogue is illustrated by the peptide binding affinity enhancement towards the CRH receptor and ... towards the design and synthesis of new molecules with higher binding affinity and enhanced stability against biological degradation and possibly biological ac...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo Y học: Reconstructing the replication complex of AcMNPV pdf
... with 2 lg of the reporter plasmid pCAPCAT, and either 0.5 lg of each of the clones of the overlapping AcMNPV k library or 1.0 lg of each plasmid of the overlapping lef library as described by Passarelli ... focus of this paper was to further elucidate the roles of replication LEFs and the nature of the AcMNPV replication complex by studying their inte...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo khoa học: Mapping the binding domains of the aIIb subunit A study performed on the activated form of the platelet integrin aIIbb3 pot
... of the ligand- binding domains of the receptor remains controversial, mainly owing to the fact that integrins are conformationally labile during purification and storage. In this study, a detailed ... complementary region 315–321 of a IIb and induces a IIb b 3 conformational change and platelet aggrega- tion [50,51]. Binding of this peptide to a IIb also induces...
Ngày tải lên: 31/03/2014, 07:20
Báo cáo Y học: Optimizing the delivery systems of chimeric RNA . DNA oligonucleotides Beyond general oligonucleotide transfer ppt
.. . antisense oligonucleotides. Eur. J. Pharm. Biopharm. 50, 101–10 9. 1 0. Gamper, H.B., Parekh, H., Rice, M.C., Bruner, M., Youkey, H. & Kmiec, E.B. (2000) The DNA strand of chimeric RNA/ DNA oligonucleotides .. . mutagenesis of the factor IX gene by chimeric RNA/ DNA oligonucleotides. Nat. Med. 4, 285–29 0. 2 8. Kren, B.T., Parashar, B., Bandy...
Ngày tải lên: 31/03/2014, 08:20
báo cáo hóa học: " On the potential role of glutamate transport in mental fatigue" ppt
... overstimulation of the cerebral cortex. Here, the final shutdown of the glutamate transmission could be one mechanism underlying mental exhaustion (figure 1). In line with these theoretical proposals, increased ... fatigue. In addition, the decrease in noradrenaline and serot- onin release might be part of decreased attention and the appearance of depression ofte...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo hóa học: "Mapping the Polarization Pattern of Plasmon Modes Reveals Nanoparticle Symmetry" pdf
... wavelengths of the excitation light, different oscillation modes are excited making it important to know the polarization pattern as a function of wavelength. ‘‘Knowing the polarization pattern of plasmonic ... SPOTLIGHTS Mapping the Polarization Pattern of Plasmon Modes Reveals Nanoparticle Symmetry Published online: 5 September 2008 Ó to the author 20...
Ngày tải lên: 22/06/2014, 01:20
Báo cáo toán học: "On the Asymptotic Distribution of the Bootstrap Estimate with Random Resample Size" ppsx
... Vietnam Journal of Mathematics 33:3 (2005) 261–270 On the Asymptotic Distribution of the Bootstrap Estimate with Random Resample Size * Nguyen Van Toan Department of Mathematics, College of Science, Hue ... the bootstrap with random resample size which is not independent of the original sample. We find sufficient conditions on the random resample siz...
Ngày tải lên: 06/08/2014, 05:20
Báo cáo toán học: "On the genus distribution of (p, q, n)-dipoles" pps
... 05C30 Abstract There are many applications of the enumeration of maps in surfaces to other areas of mathematics and the physical sciences. In particular, in quantum field theory and string theory, there ... i 1 (i − 1) (p, q, n)-dipoles of the second type. In fact, even when considering different rootings of the same dipole, we can obtain different expressions for the...
Ngày tải lên: 07/08/2014, 15:22
Báo cáo y học: "Mapping the complexity of transcription control in higher eukaryotes" docx
... expression of many genes and any given gene is typically regulated by at most a handful of transcription factors (TFs) [1]. Some studies in animals, including studies of the early development of Drosophila, ... e complexity of life does not correlate with an increased size of the list of parts (the genes) from which organisms are built, but rather with an increa...
Ngày tải lên: 09/08/2014, 20:21
Báo cáo y học: ""Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence" doc
... toxicity. Finally, we are currently searching for novel γ-glutamyl-cysteine synthetase inhibitors acting in the nanomolar range and displaying lower toxicity than BSO in uninfected cells. The concept ... and LA conducted synthesis and development of the HDACi. LA conducted the HDAC inhibitory assays. ATP and EG contributed the idea of using BSO for HIV-1 es...
Ngày tải lên: 12/08/2014, 23:21
Báo cáo y học: "Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery" docx
... CT: carried out analysis of brush biopsy samples, analyzed data. PDJ: Conceived data analysis workflow, analyzed and interpreted data. BJH: carried out collection and analysis of saliva samples. ... iTRAQ- Multidimensional Liquid Chromatography and Tandem Mass Spectrometry-Based Identification of Potential Biomarkers of Oral Epithelial Dysplasia and Novel Networks between...
Ngày tải lên: 13/08/2014, 13:20
Báo cáo y học: " Mapping the potential distribution of high artemisinin-yielding Artemisia annua L. (Qinghao) in China with a geographic information system" ppsx
... original work is properly cited. Research Mapping the potential distribution of high artemisinin-yielding Artemisia annua L. ( Qinghao ) in China with a geographic information system Linfang ... data of wild A. annua L. and interviews in Youyang County in 2008. Due to the excellent quality of A. annua L. from the habitats in Youyang Coun...
Ngày tải lên: 13/08/2014, 15:21
Báo cáo y học: "Towards the uniform distribution of null P values on Affymetrix microarrays" doc
... (black lines) presents the P values reported by the R implementation of the cyber t test. We see that, despite the correction for lack of independence by increasing the number of degrees of freedom, the P ... vigorously disputed by the authors of the Choe dataset, who argue that the non -uniform distribution of P values may be a common feature of m...
Ngày tải lên: 14/08/2014, 07:21