Báo cáo y học: "Eriocaulon buergerianum extract protects PC12 cells and neurons in zebrafish against 6-hydroxydopamine-induced damage" pps

... pathway may be involved. Background A hydroxylated analogue of dopamine, namely 6-Hydro- xydopamine (6-OHDA) which induces damage of dopa- minergic neurons in vivo and in vitro, is commonly used in ... viability of dopaminergic (DA) neuron in zebrafish was examined by anti-tyrosine hydroxylase (TH) immunostaining. The locomotor activity of zebrafish was assessed with a digital...

Ngày tải lên: 13/08/2014, 14:20

... with thickening of the lining layer (or intima) and infiltration of the sublining layer, mainly by macrophages and lymphocytes [1]. In addition, the fluid- filled joint cavity contains numerous ... four chemokines bound to synovial tissue cells in the subin- tima and the intima in every RA and non-RA individual (Supplementary Fig. 1a for CCL5). Radiolabelled chemokine binding...

Ngày tải lên: 09/08/2014, 03:24

... bowel syndrome, atopic dermatitis, and interstitial cystitis. 7 Amor- phometric study in both infected and healthy rat intestine showed that mast cells and nerves were closely and invariably approximated ... nerves. These findings suggest that cyclosporin A may exert its therapeutic effect by inhibiting mast cell activation and by affecting the interaction between mast cells...

Ngày tải lên: 08/08/2014, 20:23

... activity in daily clinical practice and clinical trials. Conclusion The study of Vander Cruyssen and colleagues confirms that the DAS28 is a valid measure to monitor disease activity and to titrate ... low disease activity, moderate disease activity and high disease activity [7]. Interestingly, the cut-off criteria for the DAS28 that were found in this way were only slightly diffe...

Ngày tải lên: 09/08/2014, 07:20

... participated in study design, and drafted the initial manuscript. LP assisted in gen- otyping some of the control individuals. SH aided in recruit- ment and clinical phenotyping of PsA patients. PR and ... Pro72Arg). To determine differences in allele and genotyping frequencies, 2 × 2 contingency tables were used. Power calculations were performed by simulating cases and con...

Ngày tải lên: 09/08/2014, 07:20

... being present per standard-deviation increase in vitamin C/vitamin E intake before and after adjusting for energy intake, age, gender, body mass index, and tibial cartilage volume. c Change in ... 0.66 a Change in tibial cartilage volume (mm 3 ) per standard-deviation increase in vitamin C/vitamin E intake before and after adjusting for energy intake, age, gender, body mass in...

Ngày tải lên: 09/08/2014, 10:20

... our DHEA findings further suggest that in the setting of heightened inflammatory and cytokine burden, there is a relative adreno- cortical androgen insufficiency in patients with RA. In support of ... with intra- and inter-assay CVs of 6% and 12%, and those for the IGFBP-3 assay were 0.8 mg/l, with intra- and inter-assay CVs of 13% and 17%, respec- tively. Serum levels of DH...

Ngày tải lên: 09/08/2014, 10:20

... methods and analyzed by four-color flow cytometry. Percentages of CD4 + and CD8 + T cells (among CD3 + /B220 - lymphocytes) and CD5 + and CD5 - B cells (among CD19 + lymphocytes) within the ... Th17 cell activity, a finding that may have implications concerning the role of acti- vated B cells interacting with 'bystander' T cells. Interestingly, blockade of IL-1...

Ngày tải lên: 09/08/2014, 14:22

... CGIs are typically unmethylated [25,26], notwithstanding many target CpGs in them. It is likely that trans-acting regulators are actively recruited to promoter CGIs to maintain this region in a nucleosome -and ... three marks present in internal and terminal exons. Materials and methods Measurement of nucleosome occupancy and DNA methylation H2A.Z-containing nucleosomes in res...

Ngày tải lên: 09/08/2014, 20:22

... protein in induced and un-induced cells carrying WT and mutant lacZ (Figure 1d). In cells carrying WT lacZ, the concentration of GroEL increased when IPTG was added. However, in both the V567D and ... SDS polyacrylamide gel. Gels were stained with Coomassie blue and scanned for analysis. For the analy- sis of total protein, cells were lysed in BugBuster reagent containin...

Ngày tải lên: 09/08/2014, 22:23