Báo cáo y học: " Hypoxia modulates human eosinophil function" ppt

... that hypoxia increases the viability of eosinophils up to three days. This result confirms a pre- vious work in which hypoxic conditions were found to prolong eosinophil viability, as measured by ... J, Haase VH, Colgan SP: Inflammatory hypoxia: role of hypoxia- inducible factor. Cell Cycle 2005, 4:256-258. 8. Nathan C: Immunology: Oxygen and the inflammatory cell. Nature 2003, 422:675...

Ngày tải lên: 13/08/2014, 13:22

... PDGF on glycosaminogly- can synthesis by primary human lung cells. Am J Physiol Lung Cell Mol Physiol 2000, 279(5):L825-834. 7. Horino Y, Takahashi S, Miura T, Takahashi Y: Prolonged hypoxia accelerates ... regulated by p21 induction by hypoxic accumulation of p53. p27 may have a compensatory role for the p53 pathway. Hypoxic pul- monary fibroblast proliferation may contribute to the pr...

Ngày tải lên: 12/08/2014, 14:20

... applying them therapeutically [5, 6]. Type 2 diabetes is characterized by insulin re- sistance and insulin secretion deficiency. At present, there is no a single medication which treats type ... activity than full-length adiponectin. We selected gAd as the con- jugating molecule of GLP-1 in our study. This design not only may prevent the renal filtration of GLP-1, but also may yield ......

Ngày tải lên: 25/10/2012, 11:10

... fragility of loaded erythrocyte at 2, 4, 8 mg/ml pravastatin when com- pared to that of unloaded erythrocytes (Table 4). Table 4, Erythrocyte osmotic fragility of unloaded eryth- rocytes and erythrocytes ... loaded erythrocytes Hematological Indices To determine the effect of loading process on erythrocytes, normal erythrocytes, erythrocytes sus- pended in PBS, and pravastatin-loaded e...

Ngày tải lên: 25/10/2012, 11:10

... Ju ¨ lich, IBI-2, Germany Human immunodeficiency virus type 1 protein R (HIV-1 Vpr) promotes nuclear entry of viral nucleic acids in nondividing cells, causes G 2 cell cycle arrest and is involved ... incorporation of Vpr. Keywords: HIV-1; Vpr; solution structure; dodecylphos- phocholine micelles; NMR. Human immunodeficiency virus type 1 (HIV-1) is a member of the lentivirus family. In addi...

Ngày tải lên: 24/03/2014, 04:21

... Choi, Y. H., Sung, B.J., Shin, N.G., Shin, H C., Sung, Y. C. & Oh, B H. (1999a) 2.8 A ˚ resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity. Immunity 11, ... family. Recently, the crystal structure of human TRAIL showed that TRAIL is a homotrimeric protein whose subunits contain mainly b-sheets. We characterized the structural changes of recombi...

Ngày tải lên: 31/03/2014, 08:20

... N,N¢-diisopropylethylamine; DMS, dimethylsulfide; EDT, ethanedithiol; hCt, human calcitonin; MBHA, 4-methyl benzhydryl- amine resin; Mtt, 4-methyltrityl; Pip, 2-phenylisopropyl; OFm, fluoren-9-yl methylester; sCt, salmon ... in vivo hypocalcemic potencies were assessed. The novel analogues include cyclo17,21-[Asp17, D -Phe19, Lys21]hCt (2), cyclo17,21-[Asp17,Aib18,Lys21]hCt (3), cyclo17,21-[A...

Ngày tải lên: 31/03/2014, 21:21

... procollagen prolyl hydroxylases (P4HA1 and P4HA2), lysyl oxidase (LOX) and lysyl hydroxylases (procollagen lysyl hydroxylase and procollagen lysyl hydroxylase 2). Similar links between hypoxia and ... and hypoxia may be aggravated by fibrosis. In summary, severe tissue hypoxia is present in SSc and may even be involved in disease progression. Review Hypoxia Hypoxia in the pathogenesis...

Ngày tải lên: 09/08/2014, 01:22

... cytokine-free, serum-free system. J Immunol Methods 1992, 153:201-212. 23. Cheung DL, Hamilton JA: Regulation of human monocyte DNA synthesis by colony-stimulating factors, cytokines, and cyclic adenosine ... GM-CSF on human monocyte DNA synthesis and CSF receptor expression. J Interferon Cytokine Res 1999, 19:417-423. 22. Bennett S, Por SB, Stanley ER, Breit SN: Monocyte proliferation in...

Ngày tải lên: 09/08/2014, 01:22

... coactivators by HIF-α is regulated by oxygen- dependent hydroxylation of asparaginyl residues within the subunit [5]. The critical dependence of prolyl and asparaginyl hydroxylation on oxygen means ... proteolysis of HIF-α [3]. Under normoxic conditions, HIF-α subunits have a very short half- life. This is because prolyl 4-hydroxylase domain enzymes, that require oxygen as an obligatory cosub...

Ngày tải lên: 09/08/2014, 01:23