Báo cáo y học: "New treatments addressing the pathophysiology of hereditary angioedema" docx

... caused by C1-inhibitor deficiency. These agents inhibit the release or block the activity of bradykinin, the primary mediator of vascular permeabil- ity associated with HAE. They do not address the ... particularly the complement system, may contribute to the genesis, severity, and duration of the attack by contributing to the consumption of C1-inhibi- tor. Activation...

Ngày tải lên: 13/08/2014, 13:22

... to heterogeneity of the phenotype expression between endothelial cells in the body, a local endothelial cell dys- function can occur where the femoral head endothelial cells react differently to the ANFH ... cases of ANFH [21]. Even when GCs are thought to be the cause a careful history is suggested to identify other risk factors. GCs are the mainstay of therapy in most infl...

Ngày tải lên: 12/08/2014, 14:22

... anti-inflammatory activity. The anti-inflammatory effi- cacy of Ciclesonide in these studies was similar to that produced by Fluticasone but with an improved safety profile, thus demonstrating an improved therapeutic ... efficacy to the market leaders but with an improved safety profile. The same company also presented data on their PDE4 inhibitor, Roflumilast, which is now in phase I...

Ngày tải lên: 12/08/2014, 18:20

... injury due to vascular disruption, spinal cord injury and global anoxic injury following asphyxial cardiac arrest. In these conditions, any Commentary New indications for the use of therapeutic hypothermia Stephen ... and there were numerous anecdotal reports of the use of TH in the treatment of neurological injury following head injury, stroke and anoxic brain injury [1]. For r...

Ngày tải lên: 12/08/2014, 20:20

... compo- nents of the neural crest developmental gene program and then to analyze their phylogeny. Our evolutionary study, as for others based on comparative genomics, is limited by the quality of the available ... Con- sistently, in the collection of vertebrate/mammalian new genes, we found molecules defining the physiology of these novel cell types. This is the case for t...

Ngày tải lên: 14/08/2014, 20:22

... dissemi- nation of the pathogen to the pulmonary lymph nodes and to various other extrapulmonary sites occurs prior to the development of the adaptive immune responses [21,22]. The entry of M. tuberculosis ... Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S: Direct recognition of the mycobacterial glycolipid, trehalose...

Ngày tải lên: 12/08/2014, 13:22

... risk of type 2 diabetes mellitus, dyslipidemia, hypertension, stroke, ischemic heart disease and early mortality [6-9]. The authors concluded that the preva- lence of obesity in this study of outpatients ... diagnosis of general medical conditions may be delayed. As the physician with the most (and often the only) contact with these patients, psychiatrists need to be vigilan...

Ngày tải lên: 25/10/2012, 10:51

... experience with the management of disseminated disease is very limited in the literature 6 , therefore, attention to the therapy strategy of this neoplasm in the future may allow a more reasonable ... analysis of sol- id-pseudopapillary tumor of the pancreas: report of 15 cases. Hepatobilliary Pancreat Dis Int. 2008;7(2):196-200. 10. Yu CC, Yeh CN, Hwang TL, Jan YY. Cl...

Ngày tải lên: 25/10/2012, 11:40

... with their pets need not represent any risk for infection with Toxoplasma gondii. Cats are the definitive host of T. gondii; they are the only animals that pass oocysts in their feces. They become ... Veterinarians are often faced with the need to explain to their clients that it is not necessary, for example, to give away one’s cat during pregnancy and that if they follow a few...

Ngày tải lên: 03/11/2012, 11:06

... confirming the key roles of each member of the triad of carboxylates in the catalytic activity of BsArb43B. As described above, a metal ion was observed fur- ther down in the catalytic cavity, approximately ... acid identity with previously characterized ABNs. We have previously reported the crystallization and preliminary X-ray analysis of BsArb42B [18]. Here we present t...

Ngày tải lên: 15/03/2014, 23:20