Báo cáo y học: "Baicalein inhibits IL-1β- and TNF-α-induced

Báo cáo y học: "Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway" pot

... strongly inhibit production of inflammatory cytokines of IL-6, IL-8, and MCP-1 from activated mast cells through the decrease of mRNA tran- scription. On the other hand, in our study, the cytokine gene ... the production of inflammatory cytokines through inhibition of NF-κB activation and IκBα phosphorylation and degradation in human mast cells....

Ngày tải lên : 13/08/2014, 13:22

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Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx

... in epithelial cell lines, mice and humans with defective CFTR expression or function [5, 6, 10-14]. NFκΒ clearly plays a key role in the regulation of expression of pro -inflammatory cytokines, ... model parthenolide pretreatment results in an inhibition of inflammatory signaling in cells with CF defects. Production of IL-8 and other pro -inflammatory cytokines is al...

Ngày tải lên : 11/08/2014, 03:20

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Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps

... resolution of inflammation. We hypothesized that this involves tissue-specific regulation of glucocorticoids, mediated via differential regulation of the enzyme 11β-hydroxysteroid dehydrogenase type ... weakly expressed by dendritic cells. The enzyme was abundantly expressed by CD90-positive fibroblasts and by endothelial cells (identified by von Willebrand factor stainin...

Ngày tải lên : 09/08/2014, 08:22

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Báo cáo y học: "Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration" docx

... in the design of the study, performed the majority of the laboratory work and analysis, and drafted the manuscript. CLM helped to secure funding, participated in the design of the study and the ... delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therap...

Ngày tải lên : 09/08/2014, 10:23

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Báo cáo y học: " Do general practitioners and psychiatrists agree about defining cure from depression? The DEsCRIBE™ survey" pdf

... 1240 physicians were contacted, of whom 369 completed the survey (response rate of 30%). The char- acteristics of the physicians who completed the survey and of the general Belgian physician ... 1. The mean age of the participating physicians and of the Belgian physician population were comparable, while the proportion of female physicians was 7-14% l ower...

Ngày tải lên : 11/08/2014, 16:20

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Báo cáo y học: "Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study" pdf

... 3 Induction of expression of inflammatory cytokines by instillation of ATP. A. Inflammatory cytokine expression in early phase. The instillation of ATP increased significantly the mRNA expression of ... in the mechano-sensory functions of the urinary system [18,19] and of the pain- and stretch-sensing neu- rons [20]. Since mechanical stress causes the rele...

Ngày tải lên : 12/08/2014, 14:20

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Báo cáo y học: " Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells" pps

... variety of cells [2,3,47], and it up-regulates the expressions of inflammatory cytokines [3,4,41] and extrace llular mole- cules [48]. Moreover, cytokine genes are regulated by NF-B and AP-1. Therefore, ... stimulated by CSE solution. And, TGF-b production and activations of Smad3/ MAP kinases are induced by more cells than by just mast cells. Therefore, our dat...

Ngày tải lên : 12/08/2014, 13:22

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Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx

... 264.7 cells were treated with RANKL (100 ng/mL) from the first day of culture and for the entire duration of the exper- iment. The culture medium was changed every 2 days. On the fifth day, RANKL-treated ... chondrocytes, this drug acts on the IL-1β system, reducing the level of this cytokine as well as downreg- ulating the IL-1β-induced inflammatory pathways...

Ngày tải lên : 09/08/2014, 10:23

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Báo cáo y học: "Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways" pot

... various inflammatory diseases. In this study, we explored the anti -inflammatory potential of aciculatin (8-((2R,4S,5S,6R)-tetrahydro-4,5-dihydroxy-6-methyl-2H-pyran-2-yl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H- chromen-4-one), ... Thus, the anti -inflammatory agents that decrease NO and PGs production by simultaneous ly inhibitingtheiNOSandCOX-2genemayhaveapoten- tially the...

Ngày tải lên : 10/08/2014, 05:21

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