Báo cáo y học: "Impact of IL8 and IL8-Receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections" doc
Báo cáo y học: "Impact of IL8 and IL8-Receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections" doc
... Furthermore, we hypothesized that polymor-phisms within IL8 have opposite effects on the development of asthma and severe RSV infections. The hypothesis was based on the observation that the -251Tallele ... infection in the Eng-lish population [9,10].Thus the first aim of the current study was to test whetherour initial hypothesis of an opposite role of IL8 polymor-phisms on asthma and RSV infections ... severe RSV infection and/ or bronchial asthma and IL8 and IL8RA pol-ymorphisms in the German population. We chose tostudy two IL8 promoter polymorphisms (-251A/T and -781C/T) and three amino...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... sequence. Conclusions: This study represents that the Gab1 polymorphism was associated with the low risk of H. pylori infection and the high risk of gastric atrophy among seropositive healthy controls, ... affect the H. pylori infection through the level of cytokines which are advantageous to eradication of H. pylori. These results should be interpreted with caution. The question is whether these ... risk of the infection independent on severe atrophy. Although the Gab1 polymorphism prevented H. pylori infection, it was associated with the risk of atrophy identified as the precursor lesion...
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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx
... role of the D to N mutation; and (c) the role of the sequence and length of the C-terminal extension.To address whether presence of extra residues at the N-terminal of Pfg27Awere responsible ... affected severely by single amino acid mutations.However, in the present study we can exclude this possibilityas the D to N mutation is conserved in four of the sixconstructs (Fig. 1), which nonetheless ... partially soluble in five of the constructsresulting in very poor yields. Intriguingly, in the sixth con-struct, the yield of soluble fusion protein with an extendedcarboxyl terminus of 17 residues...
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Báo cáo y học: "P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis" ppsx
... during the performance of these studies and received 100% of their compensation from the com-pany.Authors' contributionsKKB, SAH and EBH performed all of the in vivo studies and analyzed the ... citation purposes)contributes to the development and maintenance of neu-ropathic pain by inducing the synthesis of inflammatorycytokines and other neuroactive molecules [42]. Adminis-tration of ... ded-ifferentiation and apoptosis of chondrocytes and increased synthesis of matrix degrading proteinases [1].There is increasing evidence that inflammation plays anactive role in pathophysiology of osteoarthritis...
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Báo cáo y học: " Secondary infection with Streptococcus suis serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs" potx
... pigs of the coinfected group had symptoms typical of PHFS, such as high fever, anorexia, and red coloration of the ears and the body. The isolation rates of HP-PRRSV and SS7 were higher and the ... effects on the immune system, and allow sec-ondary infection by SS7, thereby further exacerbating the damage to the immune system. In addition, neurotoxicityis an important feature of PRRSV infection ... infection. Further characterizati on of PHFS of pigs under laboratory and natural conditionswill be necessary to understand the mechanisms under-lying the enhanced susceptibility of HP-PRRSV-infectedpigs...
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Báo cáo y học: " Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress" potx
... up-regulation of GRP78, cyclin A and NF-B suggesting a role of NS2 inER stress activation. Additionally, NS2 induces cell cycleFigure 3 The analysis of the stages of cell division of expressing ... in the S-phase witha concomitant decrease in the proportion of cells in the G0/G1 ph ase. The cell cycle effects were associated with the activation of NF-B and the rapid degradation o fcyclin ... proportion in the G0/G1 phase (Fig. 3B).Taken together, these results strongly suggest that NS2protein causes the inhibition of cell growth by the induction of cell cycle arrest in the S-phase.CSFV...
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Báo cáo y học: "Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock" pot
... stimulation of cytokine production bylipopolysaccharide, and the alcohol induced decrease incytokine synthesis was proportional to the level of alcohol con-sumption [6]. Also, levels of production ... the onset of infection (peritonitis/pneumonia), within 12 hours after the onset of septic shock, and 72–96 hours after the onset of sep-tic shock. With each measurement, haemodynamic and oxy-gen ... elevated in early infection in patients developing sep-tic shock [29]. The latter may be the effect of a severe infectionwhereas the former may be the cause of progression of the disease. However,...
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Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx
... that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian StonyCreek FrogLitoria lesueuriJason Doyle1, Lyndon E. Llewellyn1, Craig S. ... University of Adelaide, South AustraliaTwo neuropeptides have been isolated and identi®ed from the secretions of the skin glands of the Stony Creek FrogLitoria l esueuri. The ®rst of these, the ... peptides onto their skin, some of whichare c ytotoxic and antibiotic, and others w hich regulate the neuronal isoform of the enzyme N OS. We propose t hat thiseffect on nNOS is mediated by allosteric...
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Báo cáo y học: " From antibody insult to fibrosis in neonatal lupus – the heart of the matter" pps
... For the 20-week and 22-week CHB hearts, there was a strong positive cor-relation between the absolute number of macrophages and the content of myofibroblasts. The functional implication of the ... a fetus dying in utero at 18 weeks of gestation [23] and the demonstration of patchy lymphoid aggregates through-out the myocardium of an infant delivered at 30 weeks and dying in the immediate ... antibiotic therapy. Thisabsence of permanent injury stands in strong contrast to the rapid progression to scarring seen in autoantibody-associated CHB. The expression of specific combinations of cytokines...
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Báo cáo y học: "α Anti-α-fodrin antibodies do not add much to the diagnosis of Sjögren’s syndrome" pot
... Hoogen FH: The synergistic value of focusscore and IgA% score of sublabial salivary gland biopsy for the accuracy of the diagnosis of Sjogren’s syndrome: a 10-year comparison. Rheumatology 2002, ... sera and that the majority of these antibodies are of the IgG and IgA class,but that their frequency in SjS sera is not higher than that of the classic autoantibodies directed against the Ro60 and ... sera of patients with secondary SjS was confirmed byimmunoblotting (four of four) and by immunoprecipitation(three of four) (Table 1).In our hands, the use of apoptotic extracts (to increase the amount...
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