Báo cáo y học: "Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics" potx
Báo cáo y học: "Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics" potx
... for binding to the COS-7 cell extracts in which rPGRMC1 protein was over-expressed (Fig. 2e). Identifying novel ligands for the rPGRMC1-associated binding site activity through LAGS binding site ... effect on affinity as long as the C17 chain was 1 or 2 carbons in length (Additional file 2). The position of the methyl group in dexamethasone was critical for binding to LAGS...
Ngày tải lên: 13/08/2014, 13:20
Báo cáo y học: "The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression" ppt
... targeted by a Frequency of pairs of binding sites targeted by the same miRNAs separated by a given distanceFigure 3 Frequency of pairs of binding sites targeted by the same miRNAs separated by a given ... likely that miRNAs are involved in many diseases as well. In the case of multiple targeting, we show that cancer genes tend to be targeted by more miRNAs, supporting the notion that m...
Ngày tải lên: 14/08/2014, 08:20
Báo cáo y học: "Low socio-economic status, smoking, mental stress and obesity predict obstructive symptoms in women, but only smoking also predicts subsequent experience of poor health"
... in 1968-1969; Body height and body weight were measured with the subjects wearing only briefs. Body mass index (BMI) was calculated by dividing body weight in kg by m² of body height. Mental ... results of the study suggest that life-style factors such as mental stress, obesity and smoking among women are related to airway symptoms and also quality of life many years later. Key words...
Ngày tải lên: 31/10/2012, 15:34
Báo cáo y học: " Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways"
... protein kinases phosphorylation. The most strikingly and novel finding obtained hereby was the strong inhibition of the GPCR signaling pathway induced mainly by increased phosphorylation of ... signaling pathways. It has been reported that MAPK signal cascade induces Fas ligand expression as well as Fas ligand promoter activation in T lymphocytes [33]. Our data confirmed the incre...
Ngày tải lên: 31/10/2012, 15:37
Báo cáo y học: "Low temperature tolerance of human embryonic stem cells"
... temperature-exposed hESC colonies was assessed by morphological observations under bright-field and phase-contrast microscopy, as well as by immunocytochemical staining for the pluripotency markers SSEA-3 and ... Grade A which was completely or mostly undifferentiated, Grade B which was partially differentiated, and Grade C which was mostly differentiated. Assessment of chromoso...
Ngày tải lên: 31/10/2012, 16:57
Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot
... concentration of Myr 2 Gro-PCho and TO in lipid emulsion fraction 6 ¼ 150 l M and 260 l M , respectively. Binding data was obtained by analytical ultracentrifugation using the direct binding assay as described ... Escherichia coli as fusion proteins with glutathione S-transferase using the pGEX-3X plasmid, and purified as described previously [4]. The purity of both apoE3 and apoE4...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo Y học: High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences doc
... tissue is a prerequisite for many types of infections. Diseases such as leishmaniases are is generally initiated when sand y, the vector, regurgitates promastigote form of the parasite at the time ... a single class of b inding sites, which are ionic in nature, conformation-dependent and possibly involves sulfhydryls. Binding a ctivity was significantly enhanced by Zn 2+ ,an effect possibly...
Ngày tải lên: 08/03/2014, 23:20
Báo cáo Y học: Group IID heparin-binding secretory phospholipase A2 is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues doc
... Functional association of type IIA secretory phospholipase A 2 with the glycosyl phosphatidylinosi- tol-anchored heparan sulfate proteoglycan in the cyclooxygenase- 2-mediated delayed prostanoid biosynthetic ... University of Tokyo, Tokyo, Japan; 4 College of Pharmacy, Yeungnam University, Gyonsan, Korea Group IID secretory phospholipase A 2 (sPLA 2 -IID), a heparin -binding sPLA 2 that is c...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx
... four base pairs, distamycin has an effect on at least five base pairs. The opening of the groove by distamycin (by 4A ˚ )ismore pronounced than with DAPI (1.5 A ˚ ). In the 2 : 1 side-by- side ... two distamycin orientations in the d(GGCCAATTGG) minor groove are energetically equivalent. However, as the 1 : 1 association of distamycin to AT-rich sequences is extremely fast [33], why is the...
Ngày tải lên: 24/03/2014, 04:21
Báo cáo Y học: Characterization of heparin binding by a peptide from amyloid P component using capillary electrophoresis, surface plasmon resonance and isothermal titration calorimetry ppt
... the binding partners, i.e. it is a two-phase measurement. While affinity CE and ITC are both solution phase binding assays; a reduced pH value was required in ITC to maintain peptide solubility ... amyloid P component; AP-1, S-pyridylated synthetic peptide (H-EKPLQNFTLCFR-NH 2 ); CE, capillary electrophoresis; EDC, 1-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride; GAG, glycosam...
Ngày tải lên: 31/03/2014, 23:20