Báo cáo y học: "Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options" pot

... ("capillar- ization of sinusoids"), and by changes in the microstructure of collagens (e.g., degree of hydroxylation of prolin and lysin), glycoproteins (variations of the car- bohydrate structure) and ... to fibrogenesis. Options for diagnostic and therapy Newly recognized pathogenetic mechanisms of fibrosis described above provide several innovative optio...

Ngày tải lên: 13/08/2014, 13:20

... endocytosis Under hyperoxia the endocytic capacity was reduced by approximately 50% within 24 h compared with freshly isolated cultures, and had decreased by about 75% by day 2 and 90% by day 3 ... the loss of endocytic activity was attenuated, being reduced by 32% at day 1, 65% at day 2 and 75% by day 3 (Fig. 5). Of note, the degradation capacity measured in the cultures in terms...

Ngày tải lên: 13/08/2014, 13:20

... NW, Calgary, AB T2N 2T9, Canada 2 Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 2T9, Canada 3 Department of Medicine, University of Calgary, Calgary, AB T2N ... responsibility for the integrity of the data and the accuracy of the analysis. References 1. Himmelstein DU, Jones AA, Woolhandler S: Hypernatremic dehydration in nursing home patients:...

Ngày tải lên: 25/10/2012, 10:31

... of the enthalpy and entropy changes, DH mean and DS mean , are simply given by: DH mean ¼ P m i ¼ 1 DH i n ð9Þ DS mean ¼ P m i ¼ 1 DS i n ð10Þ where DH i and DS i are the enthalpy and entropy ... thermodynamic properties of the duplex formation determined by DC P ¼ 0and DC P 6¼ 0 were extensively discussed and compared. The compensation of the temperature-dependent enthalpy...

Ngày tải lên: 22/02/2014, 07:20

... We Thank Prof B. Bhattacharyya, Bose Institute, Kolkata and Prof U. Chowdhury, University of Calcutta for their suggestions and various helps. We also thank Dr B. Sanyal, Department of Physics, Uppsala ... dehydrogenase Equilibrium and kinetic studies Suparna C. Sanyal 1 , Debasish Bhattacharyya 2 and Chanchal Das Gupta 1 1 Department of Biophysics, Molecular Biology and Genet...

Ngày tải lên: 08/03/2014, 23:20

... M.H. (1990) S-adenosyl- L -methionine: 3¢-hydroxy-N-methyl-(S) -coclaurine-4¢-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway. Phytochemistry 29, 3505–3511. 12. ... [24]. This polypeptide had a high degree of similarity (approximately 40% identity) to Coptis 6OMT, Coptis 4¢OMT, IOMT of alfalfa [25], and 6a-hydroxymaackiain 3-O-methyltransferase...

Ngày tải lên: 17/03/2014, 10:20

... 1). Our understanding of the catalytic mechanism of DAOCS [8–10] has been significantly advanced by the determination of the crystal structure of wild-type and mutant DAOCS with various ligands [1,11–13]. ... Taiwan; 3 Department of Pharmacy and Pharmacology, The University of Bath, UK Deacetoxycephalosporin C synthase (DAOCS) catalyses the oxidative ring expansion of penicil...

Ngày tải lên: 18/03/2014, 01:20

... endocrine diseases, Fig.3.Assessmentof11b-h ydroxylase a ctivity and determination of 11b-hydroxylase capacity. (A)Assessmentof11b-hydroxylase activity of CYP11B2 var iants e xpressed i n COS-1 ... Determination of 11b-hydroxylase capacity of CYP11B2 mutants in relation to the wild-type enzyme, when incubated with 11-deoxycortisol. The 11b-hydroxylation of 11-deoxycortisol catalys...

Ngày tải lên: 24/03/2014, 03:21

... A recent study of 13 years of follow-up of early onset schiz- ophrenia reported acute schizophrenic symptoms in 22.2% of patients and depression symptoms in 30.8% of patients [9]. The same study revealed ... concepts of remission and recovery in schizophrenia. Pharmacopsychiatry 2006, 39:161-170. 55. Lindström E, Eberhard J, Levander S: Five-year follow-up during antipsychot...

Ngày tải lên: 08/08/2014, 23:21

... superiority of the new drug 43 physician-based measures [11], the practicalities of mea- surement, analysis, and interpretation raise several issues. Longitudinal observational studies typically measure ... terms of primacy and publications, data more than, say, 5 years old could very well be shared. Currently such informal data sharing exists through academic networking but the p...

Ngày tải lên: 09/08/2014, 01:23