Báo cáo y học: " Glucocorticoids activate TGF-β induced PAI-1 and CTGF expression in rat hepatocytes" potx

... and Erk inhibitor on TGF-β and dexamethasone induced CTGF expression in hepatocytesFigure 4 Effects of JNK inhibitor II and Erk inhibitor on TGF-β and dexamethasone induced CTGF expression in hepato- cytes. ... significantly enhanced TGF-β- induced PAI-1 in hepatocytes. Similar to our findings in hepatocytes, Ma and coworkers found an increase of TGF- β...

Ngày tải lên: 13/08/2014, 13:20

... analysis using splenocytes of mice with GPI -induced arthritis. Expression of TNFα -induced adipose-related protein (TIARP) mRNA and protein in spleens, joints and lymph nodes was evaluated, and fluctuation ... TIARP in the process of proliferation or differ- entiation state induced by inflammation. In fact, previous stud- ies indicated that TIARP is induced by TNFα and...

Ngày tải lên: 09/08/2014, 14:22

... (Robo)- and Slit- family are primarily known to be involved in regulating cell-cell interactions and cell-matrix interactions of migrating cells during embryonic developme nt [4] and by mediating ... in designing the study, in analysis and interpretation of the data and in drafting the manuscript. AKB conceived the study and was responsible for its design and coordinatio...

Ngày tải lên: 12/08/2014, 12:20

Ngày tải lên: 12/08/2014, 23:24

... family (p21, p27, and p57) show broader substrate specificity inactivating both cyclin D-CDK4/6 and cyclin E- CDK2 kinase complexes [28]. We examined the expression of p15 INK4 , p21 WAF1/Cip1 and ... downregulates c-Myc expression and ERK1/2 phosophorylation The c-Myc inhibitor 10058-F4 we used was isolated by Yin et al. [21] using a yeast two-hybrid system. In order to bind D...

Ngày tải lên: 09/08/2014, 01:22

... character- ized by eosinophilia and by airway remodeling including transformation of the epithelium into a secretory (PAS- Table 1: Viable, apoptotic, necrotic and cytolytic eosinophils in mice with OVA -induced ... stimulation directly induced cytolysis in these eosinophils through subcellular effects critically deviating from the apoptosis pathway [12]. The time course of cytolys...

Ngày tải lên: 12/08/2014, 18:22

... VEGF-VEGFR2 signaling system. Therefore, the impai red VEGF-VEGFR 2 signaling systems likely induce a decrease in angiogenesis and neuronal signaling in the brain and are implicated in aging -induced cognitive ... VEGF/PDGF signaling system in the brain and that the downregulation could be reversed by CTS administration. VEGF is a hypoxia-inducible secreted protein that interac...

Ngày tải lên: 13/08/2014, 14:20

... Hospital Gauting and Helmholtz Zentrum München, Munich, Germany. 6 Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University of Greifswald, ... interviews and self- administered questionnaires on lifestyle and health related factors, medical history and respiratory symptoms were performed. Cardiovascular (heart attack, str...

Ngày tải lên: 25/10/2012, 10:45

... various clinics were included in the study and kept at -70ºC until per- forming laboratory study. Coombs anti-brucella test (Vircell, S.L., Spain), ELISA Ig G and Ig M (Vircell, S.L., Spain) and ... re- spectively. Evaluation of two Ig’s together rather than one by one increases their sensitivity and specificity values. The Ig G and Ig M sensitivities found in our study we...

Ngày tải lên: 25/10/2012, 10:56