Báo cáo y học: "Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cell" doc

... number not for citation purposes) Comparative Hepatology Open Access Research Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate ... endothelin B receptor (ETBR) mRNA. ET-1 had no effect on DNA synthesis in 1st passage HSC, but reduced DNA synthesis in 4th passage HSC by more than...

Ngày tải lên: 13/08/2014, 13:20

... provided the original work is properly cited. Research Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study Marcel ... vitro investigations indicates that APC may stimulate fibrinolysis by inhibiting the main inhibitor of this system, PAI-1 [29,30]. To study the effect of lethal influenza A infection on fi...

Ngày tải lên: 13/08/2014, 20:21

... Berlin, Germany; 2 Humboldt University Berlin, Institute of Biology, Theoretical Biophysics, Berlin, Germany; 3 Humboldt University Berlin, Medical Faculty (Charite ´ ), Institute of Biochemistry, ... the complexity of cellular meta- bolism. Therefore, the presented work is primarily intended to gather deeper insight into general strategies underlying commonly erratic temporary gene express...

Ngày tải lên: 17/03/2014, 10:20

... controls [18]. The microarray assay used (Panorama Cytokine Gene Array membranes; Sigma Genosys, Inc) included 375 genes enriched in cytokines, chemokines, cell surface 286 ably derive from studies ... (TRAIL recep- tors 3 and 4), IL1RAP (interleukin-1 receptor accessory protein), TGFBR3 (transforming growth factor-β receptor type III), and CCR7 (a T cell chemokine receptor important for...

Ngày tải lên: 09/08/2014, 01:23

... involved in a given pathophysiol- ogy. Our analysis identified key regulators of innate immu- nity and inflammation including the proinflammatory mediators formyl peptide receptor 1, ICAM-1 (intercellular adhesion ... for 0.7 ND Transthyretin (prealbumin); carrier protein, transports thyroid transthyretin hormones and retinol in the plasma L25665 HSR1 GTP-binding protein 0.6 ND Putative G...

Ngày tải lên: 09/08/2014, 01:23

... their own pro-inflammatory cytokines, including IL-1β and tumor necrosis factor-α, under the influence of proinflammatory cytokines present in the synovial tissues of patients with early OA [23,24], ... osteoarthritic donors (OA donor 1, age 78 years; OA donor 2, age 68 years; OA donor 3, 50 years) and two healthy donors (healthy donor 1, age 50 years; healthy donor 2, age 42 years) were ha...

Ngày tải lên: 09/08/2014, 10:20

... changes in degenera- tion include altered matrix synthesis, including a decrease in glycosaminoglycan production and an increase in collagen type I within the NP, and upregulation of matrix-degrading enzymes ... Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human interverte- bral disc: an in situ zymo...

Ngày tải lên: 09/08/2014, 14:20

... Ret receptor tyrosine- kinase signalling component and a glycosylphosphati- dylinositol-anchored GDNF family receptor α (GFRα) protein receptor complex [9]. In vitro studies of neurturin have demonstrated ... in close proxim- ity or within their target organs [3]. Glial cell line-derived neurotrophic factors, including glial cell line-derived neu- rotrophic factor (GDNF), neurturin (NTN...

Ngày tải lên: 10/08/2014, 09:22

... maintaining hepatitis B immunity in hemodialysis patients. vaccine 2002, 20:3230-35. 21. Pyone kyi K, May Oo K, Moh Htun M, Win Maw T, Khin Khin A, San San O, et al.: Clinical trial of the intradermal ... Antibody seroconversion but they did not explain the amount of antibody titers in detail. In our study only non-vaccinated stable hemodialysis patients were received Levamisole via...

Ngày tải lên: 11/08/2014, 10:23

... injec- tion of OP-1 into the nucleus pulposus completely abol- ished bradykinin receptor b1 [26]. Although by gene array we did not identify significant changes in the expression of bradykinin ... [26], bradykinin and bradykinin inducible receptor b1[26]. Therefore, it was o f interest to examine expression of neuromediat ors and their receptors in the present array study. After stimu...

Ngày tải lên: 12/08/2014, 15:22