Báo cáo y học: "Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts Cloning of new isoforms of LIF mRNA" pdf
Báo cáo y học: "Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA" pdf
... Corresponding author AbstractBackground: The cytokine leukemia inhibitory factor (LIF) mediates its biological effects throughbinding to its high affinity receptor made of the low-affinity LIF receptor ... by the addition of interleukin-4.Conclusions: We show for the first time the expression of LIF in human liver myofibroblasts, aswell as of two new isoforms of LIF mRNA. Expression of LIF by ... beendescribed in human liver. Therefore, the aim of this study was to examine the expres-sion of LIF and of its specific receptor gp190 in human liver. Results obtained with immunostaining of liver...
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Báo cáo Y học: Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo potx
... HoraÂkovaÂ1, Ivo SyrovyÂ1, Saverio Cinti2 and Jan KopeckyÂ11Department of Adipose Tissue Biology and Center for Integrated Genomics, Institute of Physiology,Academy of Sciences of the Czech ... development of obesityby both, increasing energy expenditure and d ecreasing in situlipogenesis. In order to further analyse consequences of respiratory uncoupling in white fat, the eects of the ... studied.Reduction of adiposity by respiratory uncoupling in adipocytes may be limited by mitochondrial oxidativecapacity. Importantly, it has been sho wn in vitro [42] thatthe uncoupling, induced by ectopic...
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Báo cáo y học: "Expression of tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase-3 in proliferated synovium in a patient with synovitis-acne-pustulosis-hyperostosis-osteitis syndrome: a case report" doc
... shown in rheumatoid arthritis (RA), proliferated synovium is amajor source of proinflammatory cytokines and protei-nases. TNF-a is a key cytokine, which triggers theinflammatory cascade and ... to TNF receptorstriggers pathological events in RA. These findings indicatethat synovitis and the processing of TNF-a by TACE arevery important aspects in the pathogenesis of SAPHOsyndrome. ... (M0814;DakoCytomation, Denmark).After arthroscopic synovectomy, her knee symptomsimmediately diminished and laboratory data (MMP-3 and CRP) normalized within 2 weeks of surgery. In the2-year follow-up...
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Báo cáo y học: " Expression of transforming growth factor- in chronic idiopathic cough" pdf
... These indicate that there is anincreased amount of TGF expressed in the airways thatcould be involved in the airway wall remodelling of chronic cough. This is supported by the findings of a ... through inflammatory mechanisms, providing apositive feed-forward system for cough persistence. Theremay be an induction in the upper airways of inflamma-tion and tissue remodelling induced by various ... of airway inflammation and remodeling in chroniccough. J Allergy Clin Immunol 2005, 116(3):565-70.25. McGarvey LP, Forsythe P, Heaney LG, MacMahon J, Ennis M: Bron-choalveolar lavage findings...
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Báo cáo y học: " Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients" potx
... swelling and pro-gressive destruction of multiple joints. The systemic nat-ure of RA causes, next to loss of joint function,substantially decreased quality of life and increased mor-tality of ... mainly basedon immunosuppressive disease-modifying antir heum aticdrugs, among them the rapidly e xpanding family of biologic agents [1]. Close monitoring of disease activityis mandatory for ... Germany.2Department of Neurology - Inflammatorydisorders of the nervous system and neurooncology, University of Muenster,Domagkstr. 13, Muenster, 48149, Germany.3Department of Medicine II...
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Báo cáo y học: "Expression of infectious murine leukemia viruses by RAW264.7 cells, a potential complication for studies with a widely used mouse macrophage cell line" ppsx
... B-cells and megakaryocytes in a mouse injected with 264.7-MuLV and that developed thymic lymphoma at 119 days (IHC, hematoxylin, ×200).Thymic lymphoma induced by 264.7-MuLV, 164 days post injectionFigure ... supported in part by the Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases and Divisions of Research Services, Office of the ... non-lymphoid and diagnosed as erythro- leukemia based on splenomegaly with a high frequency of erythroid cells and lack of reactivity with CD3 and PAX5.These neoplasms, not usually seen following...
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Báo cáo y học: "Expression of Human Globular Adiponectin-Glucagon-Like Peptide-1 Analog Fusion Protein and Its Assay of Glucose-Lowering Effect In Vivo"
... sequence was a glycine-rich short peptide including 15 amino acids: [N-(Serine-glycine)7- Serine-C], which was used as a linker to connect the N-terminus of gAd and the C-terminus of GLP-1-A. ... inactivation by dipeptidyl peptidase IV and by renal clearance [5, 6, 13]. Many attempts have been made to increase its biological half-life and its efficacy in vivo by producing dipeptidyl peptidase ... treat type 2 daibetes by improving both insulin resistance and insulin secretion deficiency. However, we only ob-served the glucose-lowering effect of the whole fusion protein in this study....
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Báo cáo y học: "Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus"
... epithelial layers of reticular subtype of oral lichen planus patient (streptavidin-biotin amplified system, x 400). Figure 2. Increased labelling of hMSH2 protein in basal and intermediate ... counterstained with Meyer’s haematoxylin and mounted in PermountTM. Negative controls consisted of omission of the primary or the secondary antibody or primary incubation in the presence of non-immunized ... errors and homologous recombination [13]. MMR genes, including hMSH2, hMLH1, hMSH3, hMPS1, hPMS2 and GTBP/hMSH6 are very important in distinguishing and repairing misparing and slippage errors in...
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Báo cáo Y học: Expression of the V-ATPase proteolipid subunit of Acetabularia acetabulum in a VMA3-deficient strain of Saccharomyces cerevisiae and study of its complementation pdf
... twodifferent cDNAs coding for the subunits A and B of V-ATPase. The intracellular localization of these isoforms and the combination of the isoforms is yet to be determined.We are now trying to express ... the subunit a of mouse enzyme [22,23], four isoforms of the proteolipid subunit in Caenorhabditis elegans [24] and two isoforms of the subunit A in human osteoclastoma [25]. Isoforms in higher plants ... cDNA and genomic cloning of sugar beet V-typeH1-ATPase subunit A and c isoforms: evidence for coordinateexpression during plant development and cooridinate induction in response to high salinity....
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Báo cáo Y học: Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting docx
... Kuhne,Pierre Flandin, Jean-Paul Giacobino and Patrick MuzzinDepartment of Medical Biochemistry, Faculty of Medicine, University of Geneva, SwitzerlandUncoupling protein-3 (UCP3) is a mitochondrial inner-membrane ... density of UCP3 protein (i.e. the intensity of thesignal expressed per mg of proteins) was similar in the SSmitochondria of the two glycolytic muscles, tibialis anterior and gastrocnemius, and ... notnecessarily result in similar changes at the protein level and indicate that UCP3 density in SS and IMF mitochondria canbe differently affected by metabolic changes.Keywords: fasting; intermyofibrillar...
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