Báo cáo y học: " Kupffer cells promote lead nitrate-induced hepatocyte apoptosis via oxidative stress" doc

... Pb(NO 3 ) 2 (4 hours) GdCl 3 + Pb(NO 3 ) 2 (24 hours) % 1 day 3 days 5 days 1 day 3 days 5 days 1 day 3 days 5 days 1 day 3 days 5 days Necrosis 5 (1.2) 7 (2.1) 8 (2.1) 5 (1.6) 15^(2.7) 16^(4.2) ... to verify the hypothesis that the apoptogenic action of Kupffer cells could be exerted by releasing factors and/or cytokines. likely in synergy with [27]. In addition, Kupffer cells may...

Ngày tải lên: 13/08/2014, 13:20

... induce apoptosis in all of the EC and whether the surviving cells do so because they respond to survival signals which may be released by the dying cells. Alternatively or additionally The CELLMAX ... prin- ciple most cell types (not only professional phagocytes like macrophages) have the ability to phagocytose apop- tosed cells [21-24] and we consider this possibility. It is unclear w...

Ngày tải lên: 12/08/2014, 14:20

... along with oxidative damage, apoptosis plays a crucial role in CS-induced lung damage [1,4-8]. Although it is hypothe- sized that interaction of oxidative stress and apoptosis leads to pathophysiological ... proteolysis [14,15]. Altogether, these results would indicate that CS-induced oxidative damage and proteolysis may lead to apoptosis of alveolar cells and overall damage t...

Ngày tải lên: 11/08/2014, 08:21

... [45]. This oxidative DNA damage of p53 gene is likely to promote neoplastic transformation of synovial cells that may subsequently contribute to disease progression and joint destruction. Oxidative ... synovial tis- sue hypertrophy, joint effusions and degradation of articular cartilage and bone. The normal synovial tissue is a relatively acellular structure with a lining layer (one t...

Ngày tải lên: 12/08/2014, 17:22

... hematopoietic progenitors promoted by inflammatory mediators could contribute to the chronicity of inflammatory diseases. Key hematopoietic stem cell homing receptors are used for inflammatory cell migration Bone ... stem cells from the circulation to the site of inflammation where they undergo a rapid proliferation phase, followed by terminal differentiation into inflammatory cells (ma...

Ngày tải lên: 08/08/2014, 21:20

... antibody binding [6]. Rituximab binds complement and induces antibody- dependent cellular cytotoxicity, effectively depleting CD20-expressing cells. In addition, signaling via CD20 Commentary B cells ... regimens employing cytokine blockage and that may be well suitable for a subset of patients. Identifying the mechanisms by which B cells control disease activity will be necessary to d...

Ngày tải lên: 09/08/2014, 01:21

... synovial macrophage population might functionally modulate the course of inflammatory arthritis. Mast cells and the synovial mesenchyme The synovial mesenchyme, consisting principally of synovial ... greatly expanded within the inflamed synovium. Equipped with an impressive array of mediators, mast cells can promote synovitis by recruiting inflammatory cells from the blood, inducing s...

Ngày tải lên: 09/08/2014, 01:24

... play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently present antigen to T cells, produce soluble factors, including cyto- kines ... revitalized interest in the central role played by B cells in disease pathogenesis [1] (Fig. 1). Accumulation of B cells in the synovium is driven by a variety of signals RA is one of on...

Ngày tải lên: 09/08/2014, 10:20

... production of TNF by T cells, but not by monocytes [13], and that earlier identification of TNF production by monocytes was likely due to T cell contamination of monocytes purified by adherence. Thus, ... approximately 50% of the increase in the number of T cells in the periphery, while the remaining 50% is due to enhanced peripheral expansion. Similarly, thymectomy decreases by approximat...

Ngày tải lên: 09/08/2014, 10:20

... generally found closely associated with T lymphocytes [16,90,93], which may signal the alternate NF-κB pathway through proinflammatory cytokines, CD154 (CD40L) and lymphotoxin-β [111,112]. Synthesis: ... Nonepithelial tissues, lymph Lymph node, spleen, inflamed tissues draining lymph nodes node, spleen, thymus Found in rheumatoid Yes (CD1a + dendritic cells) Yes Yes arthritis synovium 94. Th...

Ngày tải lên: 09/08/2014, 10:20