Báo cáo y học: "Critical role of hnRNP A1 in HTLV-1 replication in human transformed T lymphocytes" pdf

... regulation of HTLV-1 gene expression, by interfering with the binding of Rex to the XRE [12]. In the present study, we first dem- onstrate that the mutation of a putative binding site of hnRNP A1 to ... directly or indirectly impli- cated in down-modulating the post-transcriptional activ- ity of Rex. Since the mutations affect a putative binding site for hnRNP A1, these...

Ngày tải lên: 13/08/2014, 13:20

... cartilage. Staining with hematoxylin and erythrosine. Original magnification ×200. Figure 3 Titers of antibodies to matrilin-1 in mice immunized with matrilin-1Titers of antibodies to matrilin-1 in mice ... important at the induction of MIRP In order to define the infiltrating inflammatory cells in the acute and chronic phases of murine MIRP, we stained tis- sue sections diss...

Ngày tải lên: 09/08/2014, 01:24

... to elucidate a specific regulatory pathway of TGF1. Introduction Transforming growth factor 1 (TGF1) is known to be a potent inhibitor of proliferation in most cell types, including keratinocytes ... status of these mediators in the target cells. Competing interests The authors declare that they have no competing interests. Authors' contributions TN and DS conceived of the...

Ngày tải lên: 09/08/2014, 01:22

... exhibit different susceptibilities. The relative degree of mast cell mediated injury, within different muscle types, is not known. Methods: In this study we compared susceptibility of the fast-twitch, ... purposes) gastrocnemius and the fast-twitch EDL muscles. We also demonstrate that muscle fibre type, and mouse strain independently, determined susceptibility to IR injury. The suscept...

Ngày tải lên: 11/08/2014, 08:21

... the invertebrate prokineticin, astakine, and it is located on the plasma membrane of crayfish Hpt cells [26].It will be interesting to further investigate the precise role of F 1 -ATP synthase ... Using an alternative strategy for the first time in shrimp, Sritunya- laksana et al [8]showed that administration of the host VP28-Binding protein PmRab7 ( or an antibody against it ) coul...

Ngày tải lên: 12/08/2014, 04:20

... [28,30]. Tax also has the abil- ity to increase cdk4 associated kinase activity in HTLV-1 infected cells by binding to p16/INK4A, resulting in the inability of p16/INK4A to effectively inhibit cyclin ... cyclins through the C-terminus, making this protein a possible transdominant mutant. Finally, to define an inhibitor that effectively inhibited cyclin D2 associated kinase activity, w...

Ngày tải lên: 13/08/2014, 13:20

... APCs. Interestingly, the translocation of CTLA-4 into the synapse is proportional to TCR signal strength [4]. Hence, CTLA-4 might differentially restrict the expansion of T cells on the basis of the ... inflammatory APCs. Finally, B7-H3 and B7x could be important in controlling the interactions between effector T cells and non-APCs in the peripheral tissues. Similarly to the dis...

Ngày tải lên: 09/08/2014, 01:24

... activities in yeast require the use of strains lacking this acetylating activity. For this reason, the CA10 ATF2 gene was disrupted, yielding the strain, CA14. The strain, CA19 was constructed ... activity in yeast. Interestingly, Tgl1p, a potential ester hydrolase, was found to enhance steroid productivity, probably through both the availability and/or the trafficking of the CYP1 1A1...

Ngày tải lên: 08/03/2014, 08:20

... CAAAAGTCTTGGCGGACAAAATGAGGACTTGGTAC Reverse CATTTTGTCCGCCAAGACTTTTGAATACTT TCAAGTGC Q76G Forward CTTCCCGGAGGAAATGAGGACTTGGTACTTACTG Reverse CCTCATTTCCTCCGGGAAGACTTTTGAATA C N77G Forward CGGACAAGGTGAGGACTTGGTACTTACTGGATAC Reverse ... contains three domains resembling family 2 cystatins. Cystatins competitively inhibit the activity of papain- like cysteine proteases by binding to the active s...

Ngày tải lên: 17/03/2014, 10:20