Báo cáo y học: " Evidence for preferential copackaging of Moloney murine leukemia virus genomic RNAs transcribed in the same chromosomal site" ppt

... genome is mainly formed from RNA molecules synthesized on the same DNA-provirus. This property of Mo-MuLV may explain why only small subpopulations of gammaretroviruses produce recombinants. In this ... con- text, the differences in the frequencies of recombination between HIV-1 and Mo-MuLV may reflect differences in the ability of these viruses to randomly copackage g...

Ngày tải lên: 13/08/2014, 13:20

... part by modulating the degradation rate of mRNAs. In the present study we investigated the effect of UV light on the stability of mRNAs expressed using the tet-off system which allows the termination ... resulted in activation of the p38 MAP kinase pathway, as determined by phosphorylation of recombinant HSP27 in in vitro kinase assays with cytoplasmic lysates (Fi...

Ngày tải lên: 31/03/2014, 08:20

... promoters. In RORB1, nine amino acids precede the first cysteine of the DNA binding domain, while in RORB2 there are twenty residues before this cysteine. The two forms of the protein exhibit differential expression ... highest in the eye, pin- eal gland, and brain, particularly in the primary sensory cortices (layer IV of the somatosensory cortex) and the suprac...

Ngày tải lên: 11/08/2014, 17:20

... physically organized into gene clusters. They found that the pathway for biotin synthesis was lost in a yeast ancestor and then regained in the S. cerevisiae lineage by a combination of HGT from bacteria ... R18.2 Background In filamentous fungi, genes involved in the same secondary metabolite biosynthetic pathway are often located at the same locus in the genome a...

Ngày tải lên: 14/08/2014, 08:20

... therapy by only a few months decreased the ability of the monotherapy to induce remis- sion [20]. The benefits of combination therapy were unaf- fected by delay. Not all trials of early combination ... participated in a 9-month RCT of hydrox- ychloroquine versus placebo in early RA. Three years after the study ended, early DMARD therapy still resulted in less pain and di...

Ngày tải lên: 09/08/2014, 01:23

... function. According to this hypothesis, the presence of antigen within the synovium is the initiating factor leading to the 'homing' of antigen-specific T cells to the site of antigen deposition ... was performed at room temperature, resulting in the red cells and granulo- cytes' layering in the bottom of the tube. Red cells were removed from the g...

Ngày tải lên: 09/08/2014, 08:22

... miRNA-induced repression of BACE1 mRNA by masking the binding site for miR-485-5p. Indeed, miR-485-5p and BACE1-antisense compete for binding within the same region in the open reading frame of the ... LNA-antimiR indicates the specificity of the miRNA effect and further validates the miR-485-5p binding site in the coding region of BACE1 mRNA. Noncoding RNA...

Ngày tải lên: 09/08/2014, 20:22

... 15% of gene order conservation [19], as reuse of linkage breakpoints is influenced by the fragility of certain types of sequence (see, for example, [51,52]). We start by examin ing the role of ... irs specifying proteins with network proximity only remain linked in Kluyvero- myces lactis when recombination between the loci is unusually low [36]. We therefore ask whether re...

Ngày tải lên: 09/08/2014, 22:24

... are chosen based on the proximity that representatives from A. tumefaciens have to genes. serC U Y UUUU GUUUCCCCCYYCURAU Y GC R R G Y Y 5′ YG YY Y YY Y Terminator A AG C RY RY GC GC AC GC C CA C A 5′ RU UA GC AU GU GGG ... ornithine decar- boxylase enzyme that catalyzes one of the first steps in polyamine biosynthesis. We have tested whether metabolites related to this pathw...

Ngày tải lên: 14/08/2014, 14:22

... because of the absence of a functional role for supposedly silent sites. Here we examine one hypothesis, that synonymous muta- tions in mammals are under selection because they affect the thermodynamic ... ask: whether the nucleotides at synonymous sites are non-random with respect to stability; whether the excess of cytosine at synonymous sites in rodents [15] might be ac...

Ngày tải lên: 14/08/2014, 14:22