Báo cáo y học: "Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides" pptx
Báo cáo y học: "Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides" pptx
... of 12(page number not for citation purposes)RetrovirologyOpen AccessResearchInhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptidesLars Steinstraesser*1, ... occurring HDPsrepresenting different classes for inhibition of early, Env-independent steps in the HIV replication cycle. A lentiviral vector-based screening assay was used to determine the inhibitory ... purposes) The inhibitory effect against the lentiviral vector wasdetermined by preincubation of the vector with human cathelicidin LL37, recombinant human β-Defensin-2,porcine PG-1, fungal Plectasin...
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Báo cáo y học: "Treatment of euvolemic hyponatremia in the intensive care unit by urea" docx
... original work is properly ci ted The dose of urea was adjusted by the intensivistsdepending of the increase in SNa.Mean duration of treatment was six days (from 2 to42 days in the ICU). Hyponatremia ... intensive care unit. The main criticism to the use of urea orally is its taste;this is not a problem in the intensive care unit as it isusually administered by gastric tube or intravenously.No ... recovery.SNa increased more than 12 mmol/L the first day in 12 patients and in 13 patients the increase in SNa washigher than 18 mmol/L/48 hr. In two of these patients the intensivist lowered the...
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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... tosynthesize HA [7,8]. Their thick HA coats surrounding the cell surfaces contribute to their pathogenicity by allowingthem to escape from the immune systems of their hosts. The HA synthesized ... MU-meta-bolites in the inhibition of HA synthesis by MU in FM100cells. These above results indicate that something requiredfor a fully functional HA synthesis system is down-regulatedor inhibited in intact ... by the method of Bradford [31], and the results were confirmed by SDS/PAGE analysis of all the samples, according to the method of Laemmli [32].Assay of cell-free HA synthesisCell-free HA synthesis...
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Báo cáo y học: " Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest" pptx
... this hypothesis, weexamined the effect of IC261, a kinase inhibitor of CK1ε, in cell culture. IC261 was reported to selectively inhibit caseinkinase 1 compared to other protein kinases, by an ... CRYPTO-CHROME [24]. These clock proteins are also reported toregulate the cell cycle, suggesting they have a role in linking the circadian system and the cell cycle machinery [25,26].Mammalian ... isoforms of PERIOD proteinsand two isoforms of CRYPTOCHROME proteins, which areencoded by PER1, PER2, PER3, CRY1 and CRY2 genes,respectively. In order to define the role of each isoform in CK1ε-mediated...
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Báo cáo Y học: Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase A site-directed mutagenesis study docx
... measured by the dye equilibration method of Minnaert [17], in orderto assess changes in the thermodynamic properties of the flavin centre caused by the mutation and to explain the different thermodynamic ... to the N(5) flavin position is also marginallyaltered by the substitution of Y2 38 (Table 2).Steady-state and rapid reaction kinetics withD-alanine The ability of the Y2 38 mutants to catalyseD-alanine/oxygen ... holoenzymes(retaining their FAD prosthetic group). The mutants, in their oxidized state, show the typical spectrum of the FAD-containing flavoproteins (line 1 in Fig. 2), an extinctioncoefficient at 455 nm of...
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Báo cáo y học: "Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years" ppt
... antagonist therapy [23].Initiation of anti-TNF therapy in patients with very early AS orpreradiographic spondyloarthritis may prevent radiographicprogression in the spine, but there are no data as of ... (TNF), a proinflammatory cytokine, is present in biopsies of sacroiliac joints of patients with active disease, suggestingTNF involvement in the inflammatory process of AS [2]. The TNF antagonists ... BASDAI: Bath Ankylosing Spondylitis Disease Activity Index; BASFI: Bath Ankylosing Spondylitis Functional Index; BASMI: Bath Ankylosing Spondylitis Metrology Index; DMARD: disease-modifying antirheumatic...
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Báo cáo y học: " Role of clinical bioinformatics in the development network-based Biomarkers" docx
... protein-protein interactions by parsimony principle (nInferPPI), inferring protein-protein interactions based on multi-domain cooperation (nMDCinfer), molecular network aligner (nMNAligner), detecting ... or weaker interactions between genes or proteins. It has considered as one of powerful ways to detect the bifurcation of gene or protein interactions, indicating the early change of biomarkers ... haplotype inference (nPTG), identifying differentially expressed pathways via a mixed integer linear programming model (nMILPs), protein-RNA binding-site prediction (nPRNA), or network ontology...
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Báo cáo y học: " Prevalence of hallux valgus in the general population: a systematic review and metaanalysis" pdf
... undoubtedly, apoor understanding of the terms used in a questionnaireor interview will result in inaccurate self-report data.Finally, there has been poor reporting of the r eliabilityand validity of ... Li Y, Zhang YL, Chi YY, Xu F: Indirect measurement of the footshape of 319 college students of Han nationality in Liaoning province.Chinese J Clin Rehab 2006, 10:37-40.69. Hung LK, Ho YF, ... Studies included in meta-analysis, grouped by age of study population.AcknowledgementsFunding/Support: SN is currently supported by an Australian PostgraduateAward Scholarship at The University of...
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Báo cáo y học: "Retention of foreign body in the gut can be a sign of congenital obstructive anomaly: a case report" potx
... [10,11]; an intramural width of small intes-tine of 3 cm or less is considered abnormal. An abdominalCT scan is of great help in diagnosing and detecting the etiology of intestinal obstruction in 73–95% ... increasing expertise,laparoscopy can be equally effective with all of the otheradvantages of a minimal access approach. Hence, laparos-copy is now increasingly being employed for removal of ingested ... publication of this case report and accom-panying image. A copy of the written consent is availablefor review by the Editor -in- Chief of this journal.Competing interests The authors declare that they...
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Báo cáo y học: " Overexpression of sICAM-1 in the Alveolar Epithelial " pps
... andphagocytic activity of AM remain largely intact in thesemice. This preservation of AM phagocytosis may reflectincomplete blockade of mICAM-1-mediated effects by sICAM-1 . Despite relatively normal ... production of sICAM-1 in the alveolar space of wild-type mice is likely mediated by proteolytic cleavage of mICAM-1 on the surface o f type I AEC [9]. In addi-tion to proteolytic-mediated production of ... subsequently exagger-ated inflammation that may be the cause of the decreasedsurvival we observed in the K. pneumonia infection.Previous studi es examining the role of ICAM-1 in lunginflammation...
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