Báo cáo y học: "Inhibition of HIV-1 replication in primary human monocytes by the IκB-αS32/36A repressor of NF-κB" docx

... AIDS. Conclusions In this study we have addressed the role of NF-κB/IκB pro- teins in the replication of HIV-1 in primary human mono- cytes. We show a strong attenuation in the replication of a macrophage-tropic ... a macrophage-tropic HIV-1 strain expressing the IκB-αS32/ 36A repressor of NF-κB in primary cultures of human monocytes. These resul...

Ngày tải lên: 13/08/2014, 13:20

... as assessed by the Brief Pain Inventory (BPI)Annual mean costs of fibromyalgia patients according to severity of pain as assessed by the Brief Pain Inventory (BPI). The range of the BPI is from ... costs of fibromyalgia patients according to severity of pain as assessed by the Brief Pain Inventory (BPI)Annual mean costs of fibromyalgia patients according to severit...

Ngày tải lên: 09/08/2014, 14:20

... inhibitor diet therapy in a murine model of systemic lupus erythematosus. Arthritis Rheum 2007, 56:4132-4141. 7. Yang P, Zhang Y, Ping L, Gao XM: Apoptosis of murine lupus T cells induced by the selective ... steroid-sparing drugs for lupus therapy. Indeed, intermittent therapy with low doses of the COX-2 inhibitor celecoxib (Celebrex) has beneficial effects in murine models...

Ngày tải lên: 09/08/2014, 14:20

... morbidity or improving outcomes [16]. The present study similarly sought to examine the effectiveness of counselling informed by the principles of CBT and delivered by primary care practitioners ... other RCTs of psychological interventions for PND in primary care settings [11]). A total of 46 GPs received the training (some had more than one of their patients in...

Ngày tải lên: 11/08/2014, 15:22

... in cases of difficult airway management without extensive training and clinical rou- tine. As the success of emergency airway management is strongly influenced by the level of training and expertise with ... probability < 0.05. Results Normal airway All physicians successfully intubated the trachea using the Macintosh laryngoscope in the normal airway situation. In...

Ngày tải lên: 13/08/2014, 23:20

... were then cloned into the BsrGI sites of the linearized pYES 2 yEGFP, resulting in the formation of pYES 2 yEGFP -IN (GFP -IN) , pYES 2 yEGFP-152 -IN (GFP- 152 -IN) and pYES 2 yEGFP-180 -IN (GFP-180 -IN) . ... interaction in HIV-infected cellsFigure 7 NLS -IN- Pen inhibits IN nuclear import by the dissociation of IN- importin α interaction in HIV-infected cells. (...

Ngày tải lên: 12/08/2014, 23:22

... lls infecte d with HIV-1 by a differential display screen [9]. There- fore, we were interested in delineating the role of GliPR for HIV-1 replication. GliPR was identified originally in human ... the T cell line results are in line with the data in P4-CCR5 cells. Furthermore, the effect on HIV-1 replication was examined by the integrated HIV-1- LTR-driven...

Ngày tải lên: 12/08/2014, 23:23

... [9,10]. The kinase active, free form contains Cdk9 and one of several cyclin regulatory subu- nits, cyclin T1, cyclin T2a, cyclin T2b or cyclin K, with cyc- lin T1 being the predominantly associated ... for inhibition of HIV Inhibition of HIV-1 infectivity by non-cytotoxic concentra-tions of the P-TEFb inhibitors DRB, seliciclib and flavopiridolFigure 4 Inhibition of HIV...

Ngày tải lên: 13/08/2014, 05:22

... purposes) The inhibitory effect against the lentiviral vector was determined by preincubation of the vector with human cathelicidin LL37, recombinant human β-Defensin-2, porcine PG-1, fungal Plectasin ... increasing the selec- tivity of HDPs for early steps in the viral replication cycle seems to be necessary for further development of the human cathelicidin LL37...

Ngày tải lên: 13/08/2014, 13:20

... maintenance of tumor cell growth [3]. The finding that the ERK signaling pathway is involved in tumor cell migration and invasion [4,5], as well as in tubular formation induced by insulin in human endothelial cells ... NAMI-A-mediated inhibition of ERK1/2 phosphorylation may be lying upstream of ERK1/2. Using a serine/threonine kinase SPA assay kit, the capability of NA...

Ngày tải lên: 21/02/2014, 01:21