Báo cáo y học: " Analysis of HIV-1 Vpr determinants responsible for cell growth arrest in Saccharomyces cerevisiae" ppt

... di-W-containing peptides as well as for the protein-induced cytostatic effect in budding yeast. Interestingly, several Vpr mutants, mainly in the N- and C- terminal domains, which were previously reported ... biological activities of Vpr in human cells. In this study, we have per- formed a mutagenic analysis of Vpr to identify Vpr domains important for di-W peptide b...

Ngày tải lên: 13/08/2014, 13:20

... containing PGM3 particles showed specific binding to target cells in CLSM analysis and were more quantitative in a flow cytometric binding assay. In combination with a screen of various target cell ... observed for G1E-ER4 cells; however, here clearly specific binding of FV Env-contain- ing virus was only observable by using spinoculation (spin) during particle incubation with...

Ngày tải lên: 12/08/2014, 23:23

... uncer- tainty in the physical system and changes in vessel geom- etry that may occur over time, it may be advantageous to use geometry-independent modeling as a means of inde- pendently validating ... been used for three-dimensional machining of cavities in needle shafts for MEMS sensor integration within needles.[22] The possibility of using this type of approach is also su...

Ngày tải lên: 13/08/2014, 16:21

... not in the vicinity of a city having a medical university and/or hav- ing a high level health care institution. This paper concentrates on potential effects of training on the social and professional ... centrally financed and offered in one of the four medical schools. Residents practice medicine under the supervision of fully-licensed physicians, usually in a hospital or clini...

Ngày tải lên: 18/06/2014, 17:20

... semidefiniteness of M and typi- cally require only a small number of iterations, albeit every iteration requires the solution of a system of linear equations of size n × n. In the absence of monotonicity, interior ... number of users. More- over, in the case of symmetric interference crosstalk coeffi- cients, we show a surprising result that the users of IWFA in fact, unk...

Ngày tải lên: 22/06/2014, 23:20

... tis- sue-type plasminogen. Finally, C1-inh controls the pro- duction of vasoactive peptides, of which bradykinin has been significantly implicated in the development of angioedema [1,2]. Clinically, ... fibrinolytic systems. It is the main inhibi- tor of C1r and C1s of the complement system. C1-inh is also a major inhibitor of factor XII and kallikrein of the contact system, a...

Ngày tải lên: 08/08/2014, 21:20

... plays a criti cal role in viral infec- tivity, protease inhibitors targeting the catalytic site have been routinely used in combination with inhibit ors tar- geting other viral components in ... HG: Cleavage of human immunodeficiency virus type 1 proteinase from the N-terminally adjacent p6* protein is essential for efficient Gag polyprotein processing and viral infectivity. J Virol...

Ngày tải lên: 10/08/2014, 05:21

... T, Tanaka Y, Gejyo F, Fujii M: PDZ domain-binding motif of human T -cell leukemia virus type 1 Tax oncoprotein aug- ments the transforming activity in a rat fibroblast cell line. Virology 2004, ... pathway is typically activated by inflam- matory cytokines such as TNFα and IL-1, thus playing roles in inflammation as well as in apoptosis. In compar- ison, the non-canonical NF-κB...

Ngày tải lên: 12/08/2014, 23:22

... need for including elderly patients in clinical trails investigating new therapies. This fact may explain the poor performance of the MEWS as the only score examined in our study that did not include ... discrimination (AUC) and calibration (Hosmer-Lemeshow goodness -of- fit) power of the examined scoring systems in different intervals of time 1-day mortality 5-day mortality 10-...

Ngày tải lên: 14/08/2014, 08:21

... array technology using inkjet printing techniques was recently introduced by Agilent Labo- ratories (Palo Alto, California) that combines some of the favorable properties of single-channel oligonucleotide ... it is in terms of a quantity that we can estimate. Specifically, we redefine the model in equation 2 to be defined in terms of d(x il ) instead of x il . As illustrated...

Ngày tải lên: 14/08/2014, 20:22