... the life cycle of Ty1 [2]. The location of this branch suggests that it may play a role during the formation of Ty1 cDNA by facilitating the transfer of nas- cent minus-strand of Ty1 cDNA from ... Central Page 1 of 9 (page number not for citation purposes) Retrovirology Open Access Research DBR1 siRNA inhibition of HIV-1 replication Ying Ye, Jessica De Leon, Noriko Yokoyama,...
Ngày tải lên: 13/08/2014, 09:21
... of cytokines, chemokines and modulatory enzymes. Hyaluronan (HA), a negatively charged normally high molecular weight glycosaminoglycan, is ubiquitously dis- tributed in the extracellular matrix [10,11]. ... additional 18 h. Promoter activity was assayed by luciferase activity and results are displayed as fold induction of luciferase activity. These data represent the average of 6 ide...
Ngày tải lên: 11/08/2014, 08:22
Báo cáo y học: "Antisense oligonucleotide inhibition of Heat Shock Protein (HSP) 47 improves bleomycin-induced pulmonary fibrosis in rats" ppt
... tis- sue. Hydroxyproline measurement The total collagen content of the right lung was deter- mined by hydroxyproline measurement. The hydroxypro- line content was determined after acid hydrolysis of ... central role of HSP47 in the progression of ble- omycin-induced pulmonary fibrosis. In fact, HSP47 pro- tein may actively participate in the pathophysiology of pulmonary fibrosis. Co...
Ngày tải lên: 12/08/2014, 15:20
Báo cáo y học: "Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope" potx
... light microscopy; some assays were stained using Giemsa. A syncytium formation value of 100% is defined as the number of syncytia formed in the absence of peptide but in the presence of 1.5% DMSO. ... inhibitory activity, as reduction of P BLV -391 and subsequent modification of the cysteine res- idues with the sulfhydryl reactive agent Iodoacetyl-PEO 2 - Biotin failed to disrupt...
Ngày tải lên: 13/08/2014, 05:21
Báo cáo y học: "Rapamycin-induced inhibition of HTLV-I LTR activity is rescued by c-Myb" doc
... from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proceedings of the National Academy of Sciences USA 1980, 77:7415–7419. 4. Yoshida M, Miyoshi I, Hinuma Y: Isolation and ... NF-κB-associated pathway of HTLV-I activation as being sensitive to the presence of rapamycin: repression of this pathway can be alleviated by expression of c-Myb protein. Ta...
Ngày tải lên: 13/08/2014, 09:20
Báo cáo y học: "Deciphering cellular states of innate tumor drug responses" ppt
... global systemic view of cellular states, constitutes a helpful starting point to identify by-pass chemotherapy schemes designed to stimulate or inhibit a variety of targets simultaneously with ... is synthesized at the end of the S-phase and dur- Directed acyclic graph representation of ontology termsFigure 5 Directed acyclic graph representation of ontology terms. Association tre...
Ngày tải lên: 14/08/2014, 16:21
Báo cáo y học: "The human allergens of mesquite (Prosopis juliflora)" pptx
... the concentrations of the gels, the sera used [18], the accuracy of molecular weight standards or the sensitivity of the detection systems. In addition to the bands described by Thakur, we found bands ... blotted only faintly and was not included in the total numbers of mesquite allergens in this study. Before pooling the sera we noticed variation in the reactiv- ity patterns of sev...
Ngày tải lên: 13/08/2014, 13:22
Báo cáo y học: "The biological sense of cancer: a hypothesis" pptx
... damage, caused by the cytolysis of virally-infected hepatocytes and the aberrant compensa- tory proliferation of the surviving hepatocytes, seems to be essential for the development of liver tumors ... lowering of the regenerative capacity of the second tissue. If an injury were incurred in the second tissue, simultaneously or subsequently – most probably associated with the pre-acq...
Ngày tải lên: 13/08/2014, 16:21
Báo cáo y học: "Refinement and prediction of protein prenylation motifs" ppt
... AHGGYTFCG QGRCNKLVDGCYSFWQ LDK RDFYHT FTb Mm DASRPWLCYWI PHLAPTYA GEVDVRSAYCA AHGGYTFCG QGRCNKLVDGCYSFWQ LDK RDFYHT FTb Hs DASRPWLCYWI PHLAPTYA GEVDVRSAYCA AHGGYTFCG QGRCNKLVDGCYSFWQ LDK RDFYHT FTb ... Tn DASRPWLCFWI AHLAPTYA GEVDVRSAYCA AHGGYTFCG QGRCNKLVDGCYSFWQ LDK RDFYHT FTb Dm DSSRAWCVYWI AHLAPTYA GETDVRGAYCA AHGGYTFCG QGRTNKLVDGCYSFWV IDK QDLYHT FTb Ag DSSRPWMVYWI PHLATTYA GEVDVRGAYCA A...
Ngày tải lên: 14/08/2014, 14:21
Báo cáo y học: "Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study" pptx
... main metabolite of aceclofenac is 4-hydroxy- aceclofenac. The other metabolites, namely diclofenac and 4- hydroxy-diclofenac, account for only 5% of the administered dose [25]. Aceclofenac acts as ... healthy cartilage of proteoglycan synthesis rate as a measure of cartilage matrix synthesis (pg synthesis); percentage release of newly formed proteoglycans (new pg release) as a me...
Ngày tải lên: 09/08/2014, 07:20