Báo cáo y học: " Analysis of IL-12 p40 subunit gene and IFN-γ G5644A polymorphisms in Idiopathic Pulmonary Fibrosis" docx

... paucity of interferon-gamma (IFN-γ) . The paucity of IFN-γ may favor the development of progressive fibrosis in IPF. Interleukin-12 (IL-12) plays a key role in inducing IFN-γ production. The aim of ... Central Page 1 of 5 (page number not for citation purposes) Respiratory Research Open Access Research Analysis of IL-12 p40 subunit gene and IFN-γ G5644A p...

Ngày tải lên: 13/08/2014, 13:20

... deliv- ery of therapeutic genes is one of the main goals of can- cer therapy, it may be of importance for the general usage of the binary Ad expression system to investigate whether this finding is ... The resulting ratios of RC/ transgene vector are indicated. CD40L and IL-2 transgene expression analyses were performed two days p.i. by flow cytometry and ELISA, respectively....

Ngày tải lên: 12/08/2014, 04:20

... organs healthy again. So, is coronary disease treatable in general or we are chasing an unattainable dream? Subject of analysis Definition of intimal hyperplasia The subject of my analysis is arterial intimal ... rabbits, including humans. Formed initially as one-layer endothelium lining, this phenotype can either be maintained or differentiate into a normal multi-layer cellular l...

Ngày tải lên: 13/08/2014, 16:21

... highly expressed in the spleen are indicated by points in the upper portion of the panel (and are predominantly sequences derived from the spleen cDNA library) and genes more highly expressed in ... (Invitrogen). RNA quality and quantity were determined by spectrophotometry and by capillary electrophoresis using an Agilent Technologies BioAnalyzer. cDNA library construction...

Ngày tải lên: 14/08/2014, 14:21

... ATP-sensitive K + channels and, ®nally, the secretion of insulin. Bearing this in mind, we determined the activities of citrate synthase (an enzyme of the Krebs cycle re¯ecting the number of mitochondria ... groups, whereas in liver it was only present in adults and 20-day-old suckling rats. In fetal islets, GLUT-2 and glucokinase pro- tein and their mRNA increased as a...

Ngày tải lên: 31/03/2014, 15:20

... by statins [41] and/ or direct immunomodulatory effect of statins on T lymphocytes [42]. In our patients, no changes typical of any statin- related adver se events were observed. Liver enzyme and CPK ... atorvastatin group. Statin therapy in SLE may b e complicated by the reported cases of statin-induced lupus-like syndrome [38-40]. Pathogenic mechanisms may include increased cel...

Ngày tải lên: 12/08/2014, 17:22

... capacity by performing competition experiments. Indeed, the introduction of the E40F change in the background of M41L and T21 5Y resulted in a gradual reduction of the M41L+T21 5Y+ E40F, indicating ... susceptibility analysis The susceptibility for Zidovudine was determined using a cell-killing assay in MT2 cells, essentially as described before [45]. Phenotypic resistance wa...

Ngày tải lên: 13/08/2014, 06:20

... the first study comparing the efficiency and safety of five different cooling methods in inducing and maintaining hypo- and normothermia in ICU patients. Cooling using water- circulating blankets, ... water circulating pads and intravascular cooling was equally efficient in inducing hypo- and normothermia. Intravascular cooling was superior to all other cooling methods for m...

Ngày tải lên: 13/08/2014, 08:20

... microarrays. Since chromatin remodeling is involved in the regulation of HIV-1 gene expression (reviewed in [10]), differential expression of cellular genes in latently infected cells following treatment ... virus type 1 infection of CD4(+)-T-cell lines. J Virol 2003, 77:1392-1402. 24. Wen W, Chen S, Cao Y, Zhu Y, Yamamoto Y: HIV-1 infection ini- tiates changes in the expre...

Ngày tải lên: 13/08/2014, 09:21

... LIF paracrine loop in human liver that may play a role in the regulation of intra-hepatic inflammation and reinforces the concept of a major role of liver myofibroblasts in the regulation of intra-hepatic ... a continuous sinusoidal staining and in the stroma of portal tracts (Fig. 7A). In the cirrhotic liver, the sinusoidal staining was enhanced, whereas a very faint...

Ngày tải lên: 13/08/2014, 13:20