Báo cáo y học: " Signaling and regulation of G protein-coupled receptors in airway smooth muscle" ppsx

... air- way remodeling by degrading ECM proteins through its enzymatic activity or through mediating inflammatory cytokines to induce other MMPs, including MMP-2, -9, - 13 and -14, in lung [11]. ... prodomain fol- lowed by processing into two active enzymes of 45 kDa and 22 kDa [7]. MMP-12 degrades a broad range of ECM proteins, including elastin, type IV collagen, fibronectin, laminin...

Ngày tải lên: 12/08/2014, 18:20

... contractile sensitization [69,70] and actin polymerization [40] strongly suggest a physiologic role for G 12/13 signaling in ASM. Regulation of GPCR signaling Signaling by GPCRs is a highly regulated process. ... analyzing GPCR signaling in ASM Models for analyzing GPCR signaling in ASM run the spectrum of integrative to reductionist approaches, each having certain adv...

Ngày tải lên: 13/08/2014, 13:20

... is involved in the synergistic effect of muscarinic receptor stimulation with CSE PKC plays an important role as a signalling intermedi- ate in pro-inflammatory cytokine secretion by indu- cing ... ligand acetylcholine and its synthesizing enzyme choline acetyltra nsferase (ChAT) are present in several extraneuronal cell types, including airway epithelial cells, lymphocytes, eosin...

Ngày tải lên: 12/08/2014, 11:22

... centrifugation (400 g, 30 min), two fractions were obtained: a top leukocyte band containing mononu- clear cells (monocytes and lymphocytes) and a lower band containing polymorphonuclear leukocytes ... and 5¢-TCCACCTCCCGCATGAACCG CAGACA-3¢ (nucleotides 561–569), respectively. The CB 1 sense and antisense primers were 5¢-GATGTCTTTGGGA AGATGAACAAGC-3¢ (nucleotides 365–373) and 5¢-AG...

Ngày tải lên: 22/02/2014, 07:20

... A: Inhibition of interferon signalling by dengue virus. PNAS 2003, 100(24):14333-14338. 29. Lin RJ, Liao CL, Lin E, Lin Y: Blocking of the alpha interferon- induced Jak-Stat signalling pathway ... CGC GAG GTG 3' and 5' CAA GGG AGG TCA CCC GCG AGC C 3' respectively. Both primers were used in combination with a common antisense primer with the following sequence 5'...

Ngày tải lên: 11/08/2014, 08:22

... Other amino acid- rich media included: YPD [yeast extract and Bactopeptone (YP) containing 2% dextrose]; YPA (YP containing 0.05% glucose and 2% potassium acetate); and YPG (YP containing 3.5% galactose). Phospholipase ... PtdCho in vitro although not as efficiently as it hydrolyses PtdEtn and PtdSer [16] and thus may perhaps participate in regulating Golgi PtdCho levels and ge...

Ngày tải lên: 22/02/2014, 07:20

... Erlangen, Germany 2 SIRS-Lab GmbH, Winzerlaer Strasse 2, D-07745 Jena, Germany 3 Department of Internal Medicine III and Institute for Clinical Immunology, Rheumatology and Onkology, University of ... chemokine receptors were downregulated in SF PMN, supporting the notion of a differential modulation of chemokine receptors and their ligands during chronic inflammation. Th...

Ngày tải lên: 09/08/2014, 10:21

... highlights novel roles for these cytokines in regulating nerve ingrowth in the degenerate IVD and associated back pain. Introduction Low back pain is a widespread and incapacitating disorder of significant ... influence and enhance innervation and pain in the degenerate IVD. Expression of Trk-A and Trk-B by cells of the nondegenerate and degenerate IVD suggests an auto...

Ngày tải lên: 09/08/2014, 11:20

... mater- nal-zygotic and mostly-zygotic, respectively). Strikingly, the 5' IGR lengths of the small set of 282 genes belonging to the strict-zygotic class are extremely long compared to all other gene ... human, housekeeping genes are flanked by small IGRs [23-25] and are associated with low density of conserved non- coding elements. Conversely, genes neighboring large gene-free...

Ngày tải lên: 09/08/2014, 20:22

... Krugelstein U, Schlondorf G. The paranasal sinuses in CT-imaging: development from birth to age 25. Int J Pediatr Otorhinolaryngol. 1997;39:25-40. 28. Goss C. Gray’s Anatomy of the Human Body, ... prevalence of frontal sinus aplasia and agenesis using dental volumetric tomography in a population of Turkish individuals. Materials and methods We designed a retrospective s...

Ngày tải lên: 25/10/2012, 11:04