... disease. Neu- rolog 3 42 , 63 1-6 39. Auld, D. S., Kar, S., and Quirion, R. (1998)./3-amyloid peptides as direct cholinergic neuro- modulators: A missing link? Trends Neurosci. 21, 4 3 -4 9. Ball, ... Predominance of A/3 and association of Aft40 with cored plaques. Am.J. Pathol. 148 , 25 9-2 65. Gahtan, E., and Overmier, J. B. (1999). Inflammatory pathogenesis in Alzheimer's disease: Biological ... spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1. Nat. Med. 4, 45 2 -4 55. Cullen, IC M., and Halliday, G. M. (1998). Neurofibrillary degeneration and cell loss in...