Handbook of Experimental Pharmacology - Part 6 pdf
Handbook of Experimental Pharmacology - Part 6 pdf
... Na (+) -Ca(2+) exchangers by 7- chloro-3,5-dihydro-5-phenyl-1H-4,1-benzothiazepine-2-one (CGP-37157). J Pharmacol Exp Ther 3 06: 1050–1057 Paulus WJ, Goethals MA, Sys SU (1992) Failure of myocardial inactivation: ... exchanger in- hibitory peptide region-dependent inhibition of Na + /Ca 2+ exchange by SN -6 [ 2-[ 4- (4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl es...
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Handbook of Experimental Pharmacology - Part 3 pdf
... amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents. Pflugers Arch 4 46: 633 64 0 HEP (20 06) 171:73–97 © Springer-Verlag Berlin Heidelberg 20 06 Proarrhythmia D. M. Roden ... 28: 365 – 368 HEP (20 06) 171:99–121 © Springer-Verlag Berlin Heidelberg 20 06 Cardiac Na+ Channels as Therapeutic Targets for Antiarrhythmic Agents I.W. Glaaser 1 ·C.E.Cla...
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Handbook of Experimental Pharmacology - Part 8 pdf
... limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation 101 :61 6 62 3 Motomura S, Reinhar d-Zerkowski H, Daul A, Brodde OE (1990) On the physiologic role of beta-2 adrenoceptors ... Electrocardiol 6: 153–158 Yan GX, Antzelevitch C (1999) Cellular basis for the Brugada syndrome and other mecha- nisms of arrhythmogenesis associated with ST-segment elevation. Circ...
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Handbook of Experimental Pharmacology Volume 184 pdf
... intracellular chloride channels (ClC-3, -4 , -5 , -6 and -7 ) are widely expressed, but ClC-3 has a particularly high level of expression in the brain, and disruption of ClC-3 leads to impaired vesicular ... exogenous protein of interest. Comparison of high-efficiency versus low-efficiency transfections, there- fore, can help distinguish cell-autonomous versus non-cell-autono...
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Chapter 005. Principles of Clinical Pharmacology (Part 6) pdf
... Chapter 005. Principles of Clinical Pharmacology (Part 6) Principles of Dose Selection The desired goal of therapy with any drug is to maximize the likelihood of a beneficial effect while ... access to important sites of action outside plasma is highly variable, monitoring plasma concentration may not provide an accurate guide to therapy (Fig. 5-5 A ). Effects of...
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Handbook of Optical Materials Part 6 pdf
... (CDA) -4 2m T r 63 = 18 .6 063 3 CsD 2 AsO 4 (DCDA) -4 2m T r 63 = 36. 6 063 3 NH 4 H 2 PO 4 (ADP) -4 2m T r 63 = -8 .5 063 3 T r 41 = 24.5 S r 63 = 5.5 NH 4 D 2 PO 4 (DADP) -4 2m T r 63 = 11.9 063 3 NH 4 H 2 AsO 4 ... 39.9±8 0 .63 28 3-methyl-4-methoxy- T r 23 = 19.3±4 4;pr-nitrostilbene T r c 2 = 30.0±3 MNA m — r 11 = 67 ±25 0 .63 28 2-methyl-4-nit...
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Handbook of sexual dysfunction - part 6 pdf
... a half-life of 17.5 h. Brock et al. (65 ,66 ) team found that the longer half-life of the drug allowed 73% of their trial subjects to remain able to attempt intercourse over a period of 36 h when taking ... statement-update 2002. Int J Clin Practice 2002; 56: 663 67 1. Erectile Dysfunction 191 4. Melman A, Gingell JC. The epidemiology and pathophysiology of erectile dysfunc- tion....
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Handbook of Experimental Pharmacology - Part 1 pps
... clc7003@med.cornell.edu With 60 Figures and 11 Tables ISSN 017 1-2 004 ISBN-10 3-5 4 0-2 4 96 7-2 Springer Berlin Heidelberg New York ISBN-13 97 8-3 -5 4 0-2 4 96 7-2 Springer Berlin Heidelberg New York Library of Congress ... A. Shiroshita-Takeshita, S. Nattel Experimental Therapy of Genetic Arrhythmias: Disease-SpecificPharmacology 267 S.G. Prio ri, C. Napolitano, M....
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Handbook of Experimental Pharmacology - Part 1 docx
... Cohen 1 ·R.B.Robinson 2 (✉) 1 Department of Physiology and Biophysics, Stony Brook University, Room 150 Basic Science Tower, Stony Brook NY, 1179 4-8 66 1, USA 2 Department of Pharmacology, Columbia University, 63 0 W. 168 th ... surgery. Circulation 36: 663 67 2 Burdon-Sanderson JS, Page FJM (1879) On the time relations of the excitatory process in the ventricle of the heart of...
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Handbook of Experimental Pharmacology - Part 4 doc
... that form part of the contact points with inner mouth blockers are present (Fig. 2a). The lack of the P-X-P sequence in the S6 domain of KCNH2 creates a large volume of the inner vestibule of the ... (2001) Molecu- lar determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na+ channel alpha s ubunit. J Biol Chem 2 76...
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