Handbook of Experimental Pharmacology - Part 1 docx
Handbook of Experimental Pharmacology - Part 1 docx
... 630 W. 16 8th St.,
Room PH7W- 318 , New York NY, 10 032, USA
rbr1@colum bia.edu
1Introduction 42
2 Ionic Basis of Pacemaker Activity 43
2 .1 Sino-atrialNode 43
2 .1. 1InwardCurrentsoftheSino-atrialNode ... Understanding
I.S. Cohen
1
·R.B.Robinson
2
(✉)
1
Department of Physiology and Biophysics, Stony Brook University,
Room 15 0 Basic Science Tower, Stony Brook NY, 11 79 4-8 6 6...
Handbook of Experimental Pharmacology - Part 1 pps
... clc7003@med.cornell.edu
With 60 Figures and 11 Tables
ISSN 017 1- 2 004
ISBN -1 0 3-5 4 0-2 496 7-2 Springer Berlin Heidelberg New York
ISBN -1 3 97 8-3 -5 4 0-2 496 7-2 Springer Berlin Heidelberg New York
Library of Congress Control ... the studies of Mines in 19 13 and 19 14, microelectrode studies in animal prepara-
tions in t he 19 60s and 19 70s, experimental and...
Handbook of Experimental Pharmacology Volume 168 docx
... al. 19 96
1- Deoxy -1 1 -hydroxy- 1. 2
c
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∆
8
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JTE-907 2,370 35.9 Iwamura et al. 20 01
L-768242 1, 917 12 Gallant et al. 19 96
3-( 1
1
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c
14 ... 2,290
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1- deoxy-
∆
8
-THC (JWH -1 3 9)
3-( 1
1
-dimethylhexyl )- 3 ,13 4
c
18 Huffman et al. 2002
1- methoxy-...
Handbook of Experimental Pharmacology - Part 3 pdf
... Intern Med 11 1 :10 7 11 1
Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM (19 99) Inhibition of P-glyco-
protein-mediated drug transport: a unifying mechanism to explain the interaction be-
tween ... Receptor Hypothesis 10 8
8 Effect of Charge on Drug B inding: Tonic Versus Use-Dependent Block 10 8
9 Is It All Due to Charge? 11 1
10 Molecular Determinants of Drug Binding 11 4...
Handbook of Experimental Pharmacology - Part 4 doc
... 12 6
3 .1 The Molecular Basis of the I
Kr
Current 12 6
3 .1. 1 Topology of the I
Kr
Channel . 12 6
3 .1. 2 The Physiological Role of I
Kr
intheHeart 12 8
3 .1. 3 Structural Basis of I
Kr
Blockade 12 9
3 .1. 4 ... Consequences of I
Kr
Block 13 2
3 .1. 5 Modulation of I
Kr
Channel Function 13 3
3.2 The Molecular Basis of the I
Ks
Current 13 5
3.2 .1 Topology of the I
K...
Handbook of Experimental Pharmacology - Part 5 ppsx
... delayed rectifier potassium current IKs by (R )-2 -( 2,4-trifluoromethyl)-N-[2-oxo- 5-
phenyl- 1- ( 2,2,2-trifluoroethyl )-2 , 3-dihydro-1H-benzo[e] [1, 4]diazepin-3-yl]acetamide.
J Med Chem 40:3865–3868
Sesti ... mutation
A561V reduces wild-type HERG expression. J Biol Chem 275 :11 2 41 11 248
Kass RS (19 97) Genetically induced reduction in small currents has majo r impact. Circula-
t...
Handbook of Experimental Pharmacology - Part 6 pdf
... Na
(+)
-Ca(2+) exchangers by 7-
chloro-3,5-dihydro-5-phenyl-1H-4 , 1- benzothiazepine-2-one (CGP-3 715 7). J Pharmacol
Exp Ther 306 :10 50 10 57
Paulus WJ, Goethals MA, Sys SU (19 92) Failure of myocardial inactivation: ... potential of human
atrial myocytes. Am J Physiol 2 71: H 115 1–H 116 1
Benndorf K, Friedrich M, Hirche H (19 91) Reoxygenation-induced arrhythmogenic tran-
sient in...
Handbook of Experimental Pharmacology - Part 7 pot
... H (19 90) KN-62,
1- [ N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl ]-4 -phenylpiperazine, a specific
inhibitor of Ca
2+
/calmodulin-dependent protein kinase II. J Biol Chem 265:4 315 –4320
Toyofuku ... (2003) Crystal structure of a tetradecameric assembly of the
association domain of Ca
2+
/calmodulin-dependent kinase II. Mol Cell 11 :12 41 12 51
HookSS,Means AR(20 01) Ca
2...
Handbook of Experimental Pharmacology - Part 8 pdf
... myocardium.
Circ Res 40 :10 5 11 1
Kaumann AJ (19 96) (−)-CGP 12 177-induced increase of human atrial contraction through
a putative third beta-adrenocepto r. Br J Pharmacol 11 7:93–98
Kaumann AJ, Hall ... Lancet 348:7 12
Walsh KB, Kass RS (19 91) Distinct voltage-dependent regulation of a heart-delayed IK by
protein kinases A and C. Am J Physiol 2 61: C10 81 C1090
Experimental Thera...
Handbook of Experimental Pharmacology - Part 9 doc
... (2003)
Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome.
J Cardiovasc Electrophysiol 14 :11 49 11 53
314 C. Antzelevitch · J. M. Fish
Table 1 Drug-induced Brugada-like ECG ... Sci U S A 86: 814 7– 815 1
Vassilev PM, Scheuer T, Catterall WA (19 88) Identification of an intracellular peptide seg-
ment involved in sodium channel inactivation. Science 2 4...
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