Handbook of Experimental Pharmacology - Part 1 pps

... clc7003@med.cornell.edu With 60 Figures and 11 Tables ISSN 017 1- 2 004 ISBN -1 0 3-5 4 0-2 496 7-2 Springer Berlin Heidelberg New York ISBN -1 3 97 8-3 -5 4 0-2 496 7-2 Springer Berlin Heidelberg New York Library of Congress Control ... the studies of Mines in 19 13 and 19 14, microelectrode studies in animal prepara- tions in t he 19 60s and 19 70s, experimental and...

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... 630 W. 16 8th St., Room PH7W- 318 , New York NY, 10 032, USA rbr1@colum bia.edu 1Introduction 42 2 Ionic Basis of Pacemaker Activity 43 2 .1 Sino-atrialNode 43 2 .1. 1InwardCurrentsoftheSino-atrialNode ... Understanding I.S. Cohen 1 ·R.B.Robinson 2 (✉) 1 Department of Physiology and Biophysics, Stony Brook University, Room 15 0 Basic Science Tower, Stony Brook NY, 11 79 4-8 6 6...

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... delayed rectifier potassium current IKs by (R )-2 -( 2,4-trifluoromethyl)-N-[2-oxo- 5- phenyl- 1- ( 2,2,2-trifluoroethyl )-2 , 3-dihydro-1H-benzo[e] [1, 4]diazepin-3-yl]acetamide. J Med Chem 40:3865–3868 Sesti ... mutation A561V reduces wild-type HERG expression. J Biol Chem 275 :11 2 41 11 248 Kass RS (19 97) Genetically induced reduction in small currents has majo r impact. Circula- t...

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... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction ... or combinations of drugs, that their patients receive. Beneficial and adverse reactions to drug therapy can be described by a series of dose-response relations (Fig. 5 -1...

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... Intern Med 11 1 :10 7 11 1 Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM (19 99) Inhibition of P-glyco- protein-mediated drug transport: a unifying mechanism to explain the interaction be- tween ... Receptor Hypothesis 10 8 8 Effect of Charge on Drug B inding: Tonic Versus Use-Dependent Block 10 8 9 Is It All Due to Charge? 11 1 10 Molecular Determinants of Drug Binding 11 4...

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... 12 6 3 .1 The Molecular Basis of the I Kr Current 12 6 3 .1. 1 Topology of the I Kr Channel . 12 6 3 .1. 2 The Physiological Role of I Kr intheHeart 12 8 3 .1. 3 Structural Basis of I Kr Blockade 12 9 3 .1. 4 ... Consequences of I Kr Block 13 2 3 .1. 5 Modulation of I Kr Channel Function 13 3 3.2 The Molecular Basis of the I Ks Current 13 5 3.2 .1 Topology of the I K...

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... Na (+) -Ca(2+) exchangers by 7- chloro-3,5-dihydro-5-phenyl-1H-4 , 1- benzothiazepine-2-one (CGP-3 715 7). J Pharmacol Exp Ther 306 :10 50 10 57 Paulus WJ, Goethals MA, Sys SU (19 92) Failure of myocardial inactivation: ... potential of human atrial myocytes. Am J Physiol 2 71: H 115 1–H 116 1 Benndorf K, Friedrich M, Hirche H (19 91) Reoxygenation-induced arrhythmogenic tran- sient in...

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... H (19 90) KN-62, 1- [ N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl ]-4 -phenylpiperazine, a specific inhibitor of Ca 2+ /calmodulin-dependent protein kinase II. J Biol Chem 265:4 315 –4320 Toyofuku ... (2003) Crystal structure of a tetradecameric assembly of the association domain of Ca 2+ /calmodulin-dependent kinase II. Mol Cell 11 :12 41 12 51 HookSS,Means AR(20 01) Ca 2...

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... myocardium. Circ Res 40 :10 5 11 1 Kaumann AJ (19 96) (−)-CGP 12 177-induced increase of human atrial contraction through a putative third beta-adrenocepto r. Br J Pharmacol 11 7:93–98 Kaumann AJ, Hall ... Lancet 348:7 12 Walsh KB, Kass RS (19 91) Distinct voltage-dependent regulation of a heart-delayed IK by protein kinases A and C. Am J Physiol 2 61: C10 81 C1090 Experimental Thera...

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... (2003) Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome. J Cardiovasc Electrophysiol 14 :11 49 11 53 314 C. Antzelevitch · J. M. Fish Table 1 Drug-induced Brugada-like ECG ... Sci U S A 86: 814 7– 815 1 Vassilev PM, Scheuer T, Catterall WA (19 88) Identification of an intracellular peptide seg- ment involved in sodium channel inactivation. Science 2 4...

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