Antiarrhythmic Drugs A practical guide – Part 8 ppsx

... clinicians have tended to divide the supraventricu- lar tachyarrhythmias into two broadcategories:paroxysmal atrial tachycardia (PAT) and atrial flutter and atrial fibrillation. The term PAT has falleninto ... tachyarrhythmias, Class IA drugs, sotalol, and dofetilide, are roughly equal in efficacy. Class IC drugsand amiodarone are somewhat more effe ctive than are Class IA drugs, and Class IB...

Ngày tải lên: 13/08/2014, 12:20

... Basic principles Chapter 1 Mechanisms of cardiac tachyarrhythmias, 3 Chapter 2 Introduction to antiarrhythmic drugs, 36 Part 2 Clinical features of antiarrhythmic drugs Chapter 3 Class I antiarrhythmic ... Unclassified antiarrhythmic agents, 107 Chapter 8 Investigational antiarrhythmic drugs, 112 Chapter 9 Common adverse events with antiarrhythmic drugs, 117 Part 3 Anti...

Ngày tải lên: 13/08/2014, 12:20

... Suchan automatic focus can arise in the atria, the AV junction, or the ventricles and can lead to automatic atrial tachy- cardia, automatic junctional tachyc ardia, or automatic ventricular tachycardia. Automatic ... arrhythmiabeginsa nd ends. Mechanismsofcardiac tachyarrhythmias 13 Also, analogoustosinustachycardia, automatic tachyarrhythmias often have metabolic causes, suchasacute cardiaci...

Ngày tải lên: 13/08/2014, 12:20

... arrhythmias. Nonetheless, drugs that change the shape of the actionpotential canpotentially affect all three mecha- nisms of arrhythmias. Automatic arrhythmias Abnormal automaticity, whether atrial ... of an underlying characteristic ECG pattern CHAPTER 2 Introduction to antiarrhythmic drugs All cardiac tachyarrhythmias—whether caused by abnormal auto- maticity, reentry, or channelopath...

Ngày tải lên: 13/08/2014, 12:20

... Suppresses EADs and DADs + Suppresses DADs + Suppresses DADs + Efficacy Atrial fibrillation/atrial flutter – – AVN reentry – – – Macroreentry + /– – – PVCs ++ ++ + VT/VF +++ AVN, AV node; EADs, early afterdepolarizations; ... tissue, and therefore Class IA drugs have the potential of treating both atrial and ventricular tachyarrhythmias. The major clinical features of...

Ngày tải lên: 13/08/2014, 12:20

... supraventricular tachyarrhythmias Terminate or prevent AV nodal reentrant tachycardia SA nodal reentrant tachycardia Macroreentrant (bypass-tract-mediated) tachycardia Slow ventricular response Atrial tachycardia (automatic ... CNS (ataxia and nystagmus), hypersensitivity reactions (rashes and hematologic), osteomalacia, and megaloblastic anemia + – Flecainide Visual disturbances, GI (nau...

Ngày tải lên: 13/08/2014, 12:20

... in vestigational Class III antiarrhythmic agent whose efficacyagainst supraventricular arrhythmias appears to be on a par with other Class III drugs, whose efficacyagainst ventricular arrhythmias is at least ... that most arrhythmias ultimately are caused by some change in the cardi ac actionpotential and that most antiarrhythmic drugs work by causing changes in the car- diac actionpot...

Ngày tải lên: 13/08/2014, 12:20

... control patien ts. In the Canadian Amiodarone Myocardial Infarction ArrhythmiaTrial (CAMIAT) [2] and the EuropeanMyocardial InfarctAmiodaroneTrial (EMIAT) [3], amiodaroneyielded areductioninarrhythmic ... reentrant supraventricular arrhyth mias—esp ecially AV nodal reentranttachy- cardiaand bypass-tract-mediated tachycardia, that is, arrhythmias in which the AV node is part of the reentrant...

Ngày tải lên: 13/08/2014, 12:20

... interactions, 8 4 8 5 for arrhythmia treatment supraventricular arrhythmias, 8 1 8 2 ventricular arrhythmias, 8 2 8 3 for atrial arrhythmias, 82 for AV nodal reentrant tachycardias, 81 , 82 t clinical pharmacology, 8 3 8 4 for ... 110 supraventricular tachyarrhythmias atrial flutter/atrial fibrillation, 2 3–2 5, 14 0–1 50 automatic supraventricular tachyarrhythmias, 1 7–2 0 AV...

Ngày tải lên: 13/08/2014, 12:20

... always threatened. Such expansion is usually caused by graft laceration and should be immedi- ately repaired. Old and stable hematomas can, as an alternative, be treated by puncture and aspira- tion ... calcified wall. Expose the anterior and lateral aspects of the artery and use a right-angle clamp with its tip turned away from the adjacent larger vein – thus avoiding accidental...

Ngày tải lên: 11/08/2014, 01:22