Báo cáo y học: "Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice" pdf
Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... noncovalent interactions. We further found that the increase in the stability of the quintuple mutant is almost the same as the sum of the three individual stabilities [9,29]. Thus, the mutation(s) in each of the three ... evolution. Cytochrome c is unique among heme proteins in having a heme covalently attached to the polypeptide chain via two thioether bonds, f...
Ngày tải lên: 24/03/2014, 03:21
Báo cáo y học: "κ Increased AP-1 and NF-κB activation and recruitment with the β combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocyte" ppt
... that blockade of these cytokines did not fully control arthritis in all patients. Our study demonstrated the potency of cytokine combination at low concentrations. Accordingly, combination therapy acting ... directly or by acting on their upstream kinases may have an increased effect when compared with a single cytokine inhibition. Conclusion These findings indicate that interactions...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps
... even in healthy individuals. However, the very success of the concept of autoantigen dis- order in explaining the persistence of B cells directed to self- epitopes only intensifies the difficulty ... of spreading. In a key study [42] they showed that immunization of rabbits with the peptide PPPGMRPP, a repeated sequence within the carboxyl terminus of Sm B/B&ap...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis" pps
... in the Indian Ayurvedic system of medicine [20,21]. Given the potential role of PPARγ in inflammatory processes, we hypothesized that THR0921 may have protec- tive effects in a murine model of ... analysis of the hindpawsHistological analysis of the hindpaws. (a) Representative haematoxylin and eosin stained section from a control mouse shows normal cartilage and ab...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: " High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease." docx
... consistently influenced by TNF blocking therapy with infliximab in nine studied RA patients [76]. These findings could suggest that HMGB1 acts upstream of TNF in the rheumatoid synovial inflammation. Conclusion As ... Wahren-Herlenius M, Nyberg F: Translocation of the novel cytokine HMGB1 to the cytoplasm and extracellular space coincides with the peak of clinical activity...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis" ppsx
... pathway and gene network analysis of the 37 classifiersFigure 7 Canonical pathway and gene network analysis of the 37 classifiers. (a) The 37 classifiers were analyzed using ingenuity pathway analysis ... analysis for the independent test set 1 (n = 33) using the same 2,785 transcripts previously identified in the analysis of the training set. Once again, unsupervise...
Ngày tải lên: 09/08/2014, 20:20
Báo cáo y học: " Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats" pps
... response. The averaged value of BRR response obtained from three injections of phenylephrine prior to microinjection of the test agent served as the baseline control. Histology At the end of the p hysiological ... after microinjection of the test agent into NTS. The BRR response was represented by the ratio of the peak magnitude of reflex bradycardia to the p...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: " Non infective severe aortic paravalvular leakage 7 years after surgery: the role of suture technique" pot
... The surgical findings confirmed a partial prosthesis detachment at the level of the non coronary aortic sinus, due to the semicontinuous suture breaking (Figure 2). The other two sutures of the ... patients in whom a continuous suture was used [3]. On the other hand Laks et coworkers [4] had incidence of PVL of only 2.3% and Qicai [5] surprisingly 0%. The advantages...
Ngày tải lên: 10/08/2014, 09:21
Báo cáo y học: " b-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryo" docx
... embryos (17 μm) and obtained the velocity of several individual DsRed-labeled erythro- cyte in the caudal artery of DMSO- and b-lapachone- treated embryos by tracing the distance they traveled in ... Access b-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos Yi-Ting Wu 1 , Che Yi L...
Ngày tải lên: 10/08/2014, 10:20
Báo cáo y học: "Is research working for you? validating a tool to examine the capacity of health organizations to use research" doc
... through the tool as if at a regular organizational meeting. They individually completed the tool (sometimes in advance of the meeting) and then they discussed the items and their rankings, and in ... committed to increasing and/or monitoring their capacity to use research findings to inform decision-mak- ing. The study findings have demonstrated the tool's util- ity in...
Ngày tải lên: 11/08/2014, 05:21