Báo cáo y học: "Role of clinical evaluation committees in sepsis trials: from ''''''''valid cohort'''''''' assessment to subgroup analysis" pptx

... SP, Creasey AA, Xie F, Poole L, Wunderink RG: A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (Tifacogin) in patients with severe community- acquired ... Dhainaut Page 2 of 2 (page number not for citation purposes) safety and efficacy in large international integrated databases of several trials [12], and to identify subgroups...

Ngày tải lên: 13/08/2014, 11:23

... activity was due to the inability of CD4 + CD25 + Treg to migrate into the inflamed tissue. The authors also pointed out that a ‘true’ curative activity of CD4 + CD25 + Treg has been reported only in ... the paper by Frey and colleagues represents only a minor blink of an eye in the vast Treg literature, but Frey and colleagues introduce a provocative ‘spin’ to their results a...

Ngày tải lên: 09/08/2014, 06:23

... (nGNTInfer), inferring transcriptional regulatory networks from high-throughput data (nTRNInfer), inferring protein-protein interactions by parsimony principle (nInferPPI), inferring protein-protein ... correlated with clinical informatics, including patient complaints, history, therapies, clinical symptoms and signs, physician’s examinations, biochemical analyses, imaging profiles...

Ngày tải lên: 10/08/2014, 09:22

... These include include b-conglycinin, glycinin, soy vacuolar protein, Kunitz trypsin inhibitor, and other proteins [83,87-89]. Awazuhara et al detected IgE- and IgG4-binding proteins in soybean ... increasing the amount of dietary protein content from 15% to 30% of total energy while maintaining the carbohydrate con- tent (50 %of total daily caloric intake) in the diet re-...

Ngày tải lên: 31/10/2012, 14:59

... E301 in modulating the flavin potential [18], and that it might only provide an alternative means of providing protons to the flavin ring to produce the hydroquinone form upon reduction of the enzyme ... grateful to A. Stephens, University of Minneapolis and to Drs J. K. Hurley and G. Tollin, University of Arizona, for their collaboration in many aspects of this work. Work...

Ngày tải lên: 08/03/2014, 23:20

... or by targeting enzymes involved in leukotriene biosynthesis. Zileuton is a 5-lipoxygenase inhibitor that inhibits the formation of LTA 4 from arachidonic acid, thereby preventing cysteinyl leukotriene ... of his- tamine or methacholine, which indicates that these mediators are extremely potent. 5 The cysteinyl leukotrienes exert their biologic effects by binding to cysteinyl leukot...

Ngày tải lên: 08/08/2014, 20:23

... YJ, Li HZ, Tian Y, Lv YJ, Yang BF, Xu CQ: Involvement of calcium-sensing receptor in cardiac hypertrophy-induced by angiotensinII through calcineurin pathway in cultured neonatal rat cardiomyocytes. ... dehydrogenase activity (LDH) in the culture medium, as an indicator of cytotoxicity, was measured spectrophotometrically with a commer- cially available assay kit (Jiancheng Bioengi...

Ngày tải lên: 10/08/2014, 05:21

... Engagement of TLRs and RLRs results in production of type I interferon (IFN) and pro-inflammatory cytokine s. The re lease of type I IFN has been shown to amplify the innate immune responses and to be ... mediated by induction of danger signals and activation of innate signalling pathways due to the replicase activity. To investigate the innate signalling pathways involved...

Ngày tải lên: 11/08/2014, 21:21

... role of recruited PIMs in endotoxin-induced mortality in a BDL rats. It is striking that depletion of a single inflammatory cell results in remarkable reduction in key inflammatory cytokines, inhibition ... ozone- induced pulmonary injury and inflammatory mediator pro- duction. Am J Respir Cell Mol Biol 1995, 13(2):125-132. 27. Dinarello CA: Proinflammatory and anti-inflammatory c...

Ngày tải lên: 12/08/2014, 14:20

... chemokine receptors. Alternatively, they may cross-link virus particles and induce clearance of immune-complexed viruses by phagocytosis. Addition- ally, antibody dependent cellular cytotoxicity (ADCC) ... com- pletely defined. Some of such neutralizing antibodies (nAbs) may inhibit viral entry either by interfering with structures of the gp120/gp41 complex [4] or with env- epitopes tha...

Ngày tải lên: 12/08/2014, 23:21