Báo cáo y học: "Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock" ppt

... 6 Research Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock Andreas Link, Simina Selejan, ... monocytes, we used anti-CD 14- PE-Cy5 (anti-CD 14- phyco- erythrin-cyanine 5), anti-TLR4-FITC (anti-TLR4-fluorescein iso- thiocyanate), and anti-T...

Ngày tải lên: 13/08/2014, 11:23

... sensitivity indicated in this study also remains unclear because we did not measure PC20. One of the possible mechanisms is that elevation of cyclic- AMP induced by PDE 3 inhibition may play some ... and PDE 4 are the major adenosine 3' 5'-cyclic monophos- phate (cyclic-AMP) – hydrolyzing enzymes and that human airway smooth muscle contains isozymes of the PDE families [4, 5...

Ngày tải lên: 13/08/2014, 08:20

... protein, also known as CIN85 or SETA, is an adaptor-type protein belonging to the CD2AP/CMS family. It was found in complexes with many signaling proteins, including phos- phoinositol (PtdIns) ... coiled-coil domain towards the C-terminus. A variety of signaling molecules, including Grb2, Crk, Sos, Cbl were shown to interact with Cin85 via these protein–protein interaction domains [12, 14]...

Ngày tải lên: 17/03/2014, 23:20

... poly-L-lysine and poly-L- arginine) increased airway responsiveness to inhaled MCh in rats [47 ], further investigation in isolated airways revealed that hyperresponsiveness was induced only if MCh ... Access Research Hyperresponsiveness to inhaled but not intravenous methacholine during acute respiratory syncytial virus infection in mice Rachel A Collins 1 , Rosa C Gualano 2 , Gra...

Ngày tải lên: 12/08/2014, 18:20

... Hs00 242 943 _m1 2',5'-oligoadenylate synthetase-like (OASL) Hs003887 14_ m1 Guanylate binding protein 1 (GBP1) Hs00266717_m1 Guanylate binding protein 2 (GBP2) Hs00269759_m1 IL8RA Hs001 741 46_m1 C-type ... to further analyze the enormous data from microarray analysis, providing several new findings [8]. Most microarray analyses in SLE have been performed using peripheral bloo...

Ngày tải lên: 09/08/2014, 01:22

... possibility that redundant mechanisms may contribute to HMGB1 signaling and that its activity might be independent of TNF during chronic inflammation. Despite notable findings from the current study by ... membrane hypertrophy, and mononuclear cell predominance within synovial tissue [7]. The injection of rHMGB1 results in mild to moderate synovitis and may persist for at least 28 days. T...

Ngày tải lên: 09/08/2014, 10:23

... Hs00 242 943 _m1 2',5'-oligoadenylate synthetase-like (OASL) Hs003887 14_ m1 Guanylate binding protein 1 (GBP1) Hs00266717_m1 Guanylate binding protein 2 (GBP2) Hs00269759_m1 IL8RA Hs001 741 46_m1 C-type ... mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Exp Immunol 2008, 152 :48 2 -48 7. 24. Tsuchiya N, Kyogoku C: Role o...

Ngày tải lên: 09/08/2014, 13:22

... thin- walled blood vessels and prominent mixed inflammatory cells, including numerous plasma cells and lymphocytes. Immunostains showed positivity for S100, keratin AE1/AE3, and more focally ... characterized by spindle- shaped cells with chronic inflammatory cell infiltrate consisting of plasma cells, lymphocytes and occasional histiocytes [1,6]. These inflammatory cells are usuall...

Ngày tải lên: 11/08/2014, 00:22

... number not for citation purposes) Respiratory Research Open Access Correction Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human ... for 24 hr. The cells were stained with ethidium bromide and acridine orange and observed under fluorescence microscopy. Living cells had normal shaped nuclei with green chromatin. Early a...

Ngày tải lên: 12/08/2014, 15:21

... 113/2 14 (52.8) 14/ 31 (45 .2) Mean age at delivery, yr (± SD) (range) 32.5 ± 3.7 (21.9 to 40 .6) 32.1 ± 4. 5 ( 24. 2 to 40 .1) Mean gestational age at delivery, wk (range) 39 .4 (31 .4 to 42 .1) 40 .0 ( 34. 7 ... during pregnancy in patients with RA. Because pharmaceutical induction of MBL is not yet possible, this hypot hesis cannot be properly tested in vivo. However, during...

Ngày tải lên: 12/08/2014, 15:22