Báo cáo y học: "Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis" potx

... mito- chondrion and the Bcl-family of proteins in the induction of lymphocyte apoptosis during sepsis. Overexpression of Bcl-2 or adoptive transfer of Bcl-2 overexpressing lymphocytes in murine models ... shar- ing only domains 1–3 [17]; and the group of BH3-only proteins, which contain only domain 3 and function as sensors and transducers of apoptotic signals (eg,...

Ngày tải lên: 13/08/2014, 11:23

... infection of epithelial cells induce the expression of several proinflammatory cytokines and chemokines both in vitro and in vivo , which could be linked to the consequence of fatal hypercytokinemia ... mechanism of cytokine/chemokine bio- synthesis may be interrupted by the viral components. Cytokines and chemokines generally function in an autocrine (on the pro ducing...

Ngày tải lên: 12/08/2014, 02:20

... be phosphorylated by ERK to increase its DNA binding activity [27], it will be interesting to test whether the ERK activity could be induced by NBS1 overexpression, leading to the phosphorylation of ... Taipei County, 220, Taiwan. 2 Institutes of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan. 3 Institute of Bioinformatics and Systems Biology,...

Ngày tải lên: 10/08/2014, 05:21

... is involved in host inflammatory responses and is synthesized by many different cell types, including fibroblasts and epithelial cells. Expression of IL- 8 may inhibit the antiviral activity of ... is pro-inflammatory in specific cells. Further dissection of the pathways involved in HCV core-mediated signaling may provide a clearer understanding of the pathogenesis of pu...

Ngày tải lên: 12/08/2014, 18:22

... Westburn Lane, University of St Andrews, Fife, KY16 9TS, UK 2 Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Science, 46 Cleveland St, University College London, London, ... acid to tyrosine at position 116) was performed using Stratagene Quickchange (Stratagene, La Jolla, USA) methodology. Transfectants were selected and maintained in 1 mg/ml G418...

Ngày tải lên: 09/08/2014, 13:21

... problem in primary care [45]. Conversely, inquiry regarding cough in patients with mental health problems may also be crucial in identifying reversible morbidity in this group. In one study, successful treatment ... particularly depression, and significantly reduced quality of life, indicates cough is a major contrib- utor to morbidity in the community. The reduction in qual...

Ngày tải lên: 13/08/2014, 10:20

... these effects are generally displayed by nonsteroidal anti- in ammatory d rugs (NSAIDs), w e examined the effects of a cyclooxygenase inhibitor, indomethacin, and a lipoxyg- enase inhibitor, nordihydroguaiaretic ... caused by an expanded poly- glutamine tract in a cellular model of polyglutamine dis- ease. These findings suggest that NSAIDs generally induce the e xpression of hsps in...

Ngày tải lên: 30/03/2014, 15:20

... The resulting ratios of RC/ transgene vector are indicated. CD40L and IL-2 transgene expression analyses were performed two days p.i. by flow cytometry and ELISA, respectively. Asterisks indicate ... supernates of HeLa c ells, as opposed to undetectable CD40L expression in these cells, is most likely explained by the difference of sensitivity and/ or dynamic range of the as...

Ngày tải lên: 12/08/2014, 04:20

... issociated single cells after u sually 5 days and reach sizes of  5 mm; they contain proliferating cells and their interior is surrounded by an almost complete single-cellular layer of epithelial-like ... to strongly inhibit protein synthesis i n s ponge cells [22], it is concluded that the (2–5)A synthetase system is involved in defense against microorganisms, very likely by inhib...

Ngày tải lên: 21/02/2014, 15:20

... IL- 10 and M-CSF signals may be involved in the high expression of TNF receptor in lining macrophages in the inflamed ST of RA. Microarray analysis of IL-10-induced gene expression in RA monocytes To ... tissue, including the lining layer and lymphocyte infiltrates. Colocalisation analysis revealed that the CD68 + synovial lining layer contained a large number of c...

Ngày tải lên: 09/08/2014, 08:22