Báo cáo y học: "Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep" doc

... characterize ovine endotoxin-induced lung injury, a frequently used model of acute lung injury. Recombinant human activated protein C (rhAPC), with its anticoagulant, anti-inflammatory, fibrinolytic ... for citation purposes) Vol 12 No 4 Research Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep Kristine Waerhaug...

Ngày tải lên: 13/08/2014, 11:22

... al.: Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock. Critical Care 2010 14:R217. Submit your next manuscript ... hemodynamics in septic shock. • rhAPC attenuated changes in microcirculation in septic shock. Abbreviations ALI: acute lung injury; APC: activated protein C; BL: ba...

Ngày tải lên: 14/08/2014, 07:21

... as early immunologic effectors in hemorrhage- or endotoxemia- Key messages • In ovine oleic acid-induced lung injury, recombinant human activated protein C (rhAPC) ameliorates the increments in ... rhAPC in other models of lung injury in sheep [16-18]. The nearly 30% decrease in oxygen delivery was caused mainly by a combined decline in SaO 2 and CI with OA alon...

Ngày tải lên: 13/08/2014, 11:23

... nonseptic origin. Low levels of protein C in acute lung injury are associated with poor clinical outcome. The present article discusses the beneficial effects of rhAPC in oleic acid-induced lung injury ... sepsis are major contributors to mortality in burn patients [14]. The Commentary Recombinant human activated protein C in acute lung injury: what is the role...

Ngày tải lên: 13/08/2014, 11:23

... activation [2]. Thrombin may also affect the production of inflammatory cytokines by binding to protease -activated receptors (PARs) in mononuclear cells [3]. Secondly, rhAPC may inhibit the action ... 4 days, respectively (Fig. 3). Figure 2 Levels of protein C and protein C inhibitorLevels of protein C and protein C inhibitor. Plasma levels of (a) protein C and (b) pr...

Ngày tải lên: 12/08/2014, 22:22

... increases in cytokines, with partial block- Early Growth Response Protein 1 increased with stretch injury and ventilationFigure 3 Early Growth Response Protein 1 increased with stretch injury ... characterized by inflammatory cell influx into the lungs, increased alveolar protein, inflammatory cytokine mRNA induction, and systemic acute phase inflammatory responses [4]. Mechanical...

Ngày tải lên: 12/08/2014, 14:20

... activation, activated protein C when bound to the endothelial protein C receptor (EPCR), activa- tes protease -activated receptors (PARs), inducing a variety of cytoprotective cellular responses, including * ... Griffin JH: Direct detection of activated protein C in blood from human subjects. Blood 1992, 79:2340-2348. 15. Yan SB, Dhainaut JF: Activated protein C ver...

Ngày tải lên: 14/08/2014, 07:21

... of clinically significant Glc6P dehydrogenase mutants. Furthermore, our recently solved crystallographic structure of human Glc6P dehydrogenase [16,17] clearly vindicates earlier claims that each ... BamHI/SalI-cleaved pTrc99A. The recombinant plasmid, designated pTrc/ G6PD, was shown by dideoxy sequencing to contain the complete human Glc6P dehydrogenase coding sequence. Expression and pu...

Ngày tải lên: 08/03/2014, 22:20

... constructed a protein functional interaction network by extending curated pathways with non- curated sources of information, including protein- protein interactions, gene coexpression, protein domain interaction, ... annotated in pathways by defining a FI as an interaction in which two proteins are involved in the same reaction as input, catalyst, activator and/or inhibitor, or as...

Ngày tải lên: 09/08/2014, 20:22

... pro-inflamma- tory cytokines [27]. Finally, APC has neuroprotective activity in human ischaemic brain [28] by regulating cyto- solic Ca 2+ flux and blocking apoptosis in brain endothelial cells ... or traumatic [18] brain injury and significantly increases the risk of hypoglycaemia which, by itself, can induce neurocognitive dysfunction [19]. Ste- roids can decrease systemic inflamma...

Ngày tải lên: 13/08/2014, 20:21