Báo cáo y học: "Sepsis therapy: what’s the best for the mitochondria" doc

... therapy are not clearly defined. Efforts in this direction have already been made [15] and may be among the keys to future sepsis therapy. Competing interests The authors declare that they have ... Clearly, these haemodynamic effects are typical for endotoxin- induced sepsis but not for hyperdynamic sepsis, as is en- countered in patients receiving adequate haemodynamic support. Organ...

Ngày tải lên: 13/08/2014, 11:22

... a very early stage. Selecting candidates for TNF blockade therapy Identifying patients who benefit the most from TNF-blocking therapy is a reasonable strategy for optimising the use of these ... by 50% of patients in the combination group, but by only 25% in the monotherapy groups. The results of these studies show that TNF-blocking drugs, used either in combination or as monoth...

Ngày tải lên: 09/08/2014, 10:20

... significantly higher rates of the MetS [40]. This discrepancy may be a consequence of the ongoing inflammatory burden in the RA population, altering some of the components of the metabolic syndrome. The ... establish the range of discrepancy between them. For further analysis of Arthritis Research & Therapy Vol 11 No 4 Toms et al. Page 6 of 10 (page number not for citati...

Ngày tải lên: 09/08/2014, 14:22

... (Glypressine ® ; Ferring Company, Berlin, Germany), which is the form of vasopressin that is present in pig. The first clinical trial evaluating the efficacy of terlipressin in septic shock was performed in a small ... time, and patients may die in states of intractable shock [12]. The vascular hyporeactivity to catecholamines is caused, among other mechanisms, by excessive nitric oxi...

Ngày tải lên: 12/08/2014, 23:23

... pulmonary subspecialty, or (c) all others, representing anesthesia, surgery, and emergency medicine. While not perfect, their analysis is appropriate, adjusting for the type and severity of illness ... ICU mortality was signifi cantly lower for patients under the care of those trained in internal medicine and pulmonary medicine. However, when all of their data were considered,...

Ngày tải lên: 13/08/2014, 20:21

... Glu58 as the general base during the first step of the reaction. The hydrolysis of the cyclic derivative is performed by the same groups, but their roles are reversed [23]. In a-sarcin the same ... the a-fragment result- ing from the specific ribonucleolytic activity of these fungal ribotoxins against ribosomes. Forty nanograms of the wild- type protein was enough to complet...

Ngày tải lên: 31/03/2014, 23:20

... indirectly from other studies. In conclusion, the mathematical analysis of the ECG done by 3DMP appears to provide very high sensitivity and specificity for the prediction of hemodynamically relevant ... coronary angiography in the study by Weiss et al. showed a higher sensitivity and specificity for the detection of coronary stenosis by 3DMP than by 12-lead ECG [18]. O...

Ngày tải lên: 08/08/2014, 16:23

... coronary angiography in another study showed a higher sensitivity and specificity for 3DMP than for 12-lead ECG in the detection of coronary stenosis [ 21]. One lim itation of the present study ... identical copy of the data was saved on the remote 3DMP machine for post-study verification purposes before the data analysis was carried out. The quality of the tracing w...

Ngày tải lên: 08/08/2014, 17:20

... necessary for protein purification. The superna- tant was loaded to His-Bind-Resins affinity column (Novagen, Darmstadt, Germany) to purify the fusion protein. The purified protein was dialysed ... typed by mouse monoclonal antibody iso- typing kit (Sigma, St. Luis, MO, USA), the prepared mAbs were purified from cell-culture supernatant by affinity chromatography. Indirect ELISA...

Ngày tải lên: 08/08/2014, 18:21

... from day to day in a subject? Do they vary over the lifespan of the individual? What were the levels of sRAGE in the RA subjects before the onset of disease manifestation? What other environmental ... in the individual subject? Despite these caveats, a key lesson in these studies is that levels of sRAGE, at least in the synovial fluid, might be modified by intense anti-inflammat...

Ngày tải lên: 09/08/2014, 06:23