Báo cáo y học: "Bench-to-bedside review: Metabolism and nutrition" ppsx

... of hyperoxia (relatively early events). Following 24 hours of hyperoxia, however, NF-κB activation and increased levels of TNF-α mRNA were present in pulmonary lymphocytes. By 48 hours of hyperoxia, the ... activation. Reactive oxygen species (ROS) are key components of the pathways leading to the activation of NF-κB, whose binding activity is obliterated by N-acetyl- L-cysteine (NAC) and...

Ngày tải lên: 12/08/2014, 19:21

... by hypoxia and by cytokines. To identify the cellular mechanisms in control of tubular VEGF production, the effects of hypoxia and IL-1β on VEGF mRNA levels, on VEGF secretion and on activity ... injury, ischemia-reperfusion and transplantation, compromised host defense and inflammatory stimuli, and hypoxemia and the crucial role of hypoxia-inducible factor in mediating lung inj...

Ngày tải lên: 12/08/2014, 19:21

... [8–12]. These supraphysiologic levels cause Review Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology Cheryl L Holmes 1 , Donald W Landry 2 and John T Granton 3 1 Staff ... University, New York, New York, USA 3 Assistant Professor of Medicine, Faculty of Medicine, and Program Director, Critical Care Medicine, University of Toronto, and Consultant...

Ngày tải lên: 12/08/2014, 19:22

... phosphoinositide hydrolysis and intracellular calcium mobilization [49]. Adenylyl cyclases present a focal point for signal integration in vascu- lar smooth muscle, and type III adenylyl cyclase has ... activates a kinase, which phosphorylates the regulatory light chain of myosin. Phosphorylated myosin acti- vates myosin ATPase by actin and the cycling of myosin cross-bridges along acti...

Ngày tải lên: 12/08/2014, 19:22

... Oz MC, Landry DW: Vasopressin deficiency and pressor hypersensitivity in hemodynamically unstable organ donors. Circulation 1999, Suppl:II244-II246. 15. Tsuneyoshi I, Yamada H, Kakihana Y, Nakamura ... effect on oxygen metabolism (oxygen consumption being measured independent from oxygen delivery) and the oxygen delivery–consumption relationship; gastric mucosal perfusion and splanch...

Ngày tải lên: 12/08/2014, 20:20

... early response by bystanders who initiate CPR or by minimally trained rescuers, including fire and police personnel, and in which there is early response by an effective professional emergency ... ability of lay rescuers to identify cardiac arrest promptly, the availability of additional measurements, and expanded intelligence provided by expanded AEDs with which to more effectively pro...

Ngày tải lên: 12/08/2014, 20:20

... at 14 days and 28 days in this group (0.75 and 0.59, respectively) were slightly lower than in the ‘early’ (BUN ≤ 76 mg/dl) group (0.8 and 0.65, respectively). After adjustment for age and clinical ... stable and either CVVHDF or sustained low-efficiency dialysis (SLED) when they were hemodynamically unstable. In the intensive therapy arm, IHD and SLED were provided six-times per...

Ngày tải lên: 13/08/2014, 08:20

... reanalysis of the Australia and New Zealand Intensive Care Society database [16], which compared RIFLE and AKIN on the first ICU day only. Estimates of prevalence and crude mortality were very similar ... understand and apply in a variety of clinical and research settings. In recent years, the use of the consensus definitions of AKI (RIFLE and AKIN) in the literature has increased...

Ngày tải lên: 13/08/2014, 16:20

... growth factors and cytokines. For example, CXCR4/CXCL12, a general inflammatory chemokine receptor and chemok- ine ligand, is the only known chemokine receptor expressed by HSCs and plays an instrumental ... circulation[10,11]. Sim- ilarly, the inflammatory homing selectin ligand, PSGL-1 and its endothelial cell receptors P- and E-selectin, are also known to play a key role in homin...

Ngày tải lên: 08/08/2014, 21:20

... protein microarrays. Cris dos Remedios (Institute for Biomedical Research, University of Sydney, Australia) presented an antibody array technique that could reportedly identify a variety of diseases, ... followed by lectin-based two-dimensional profiling to analyze both serum proteins and glycoproteins. The lectin-based profiling allows the selection of glycoproteins by capture of the glyca...

Ngày tải lên: 14/08/2014, 17:22