Báo cáo y học: "Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats" pot
Báo cáo y học: "Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats" pot
... sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic ratsToshiaki Iba1 and Taku Miyasho21Department of Emergency and Disaster Medicine, Juntendo ... many inflammatory factors, including inflammatory cytokines, through their HS chains [2-5]. Moreover, recentdata indicate that HS and syndecan protect the host from var-ious inflammatory disorders ... treating septic organ dysfunction. In addi-tion to these changes of early mediators, other inflammatory cytokines such as IL-6, GM-CSF, and INF-γ were also lower in the DA group compared with the...
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Báo cáo y học: "beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL" pdf
... supported in part by the Office of Women's Health, FDA. The findings and conclusions in this article have not been formally disseminated by the Food and Drug Admin-istration and should ... Zidovudine(AZT) synergistically inhibited HIV-1 replication in pri-mary placental macrophages, possibly explaining whyAZT can inhibit maternal fetal transmission in the absenceof diminution ... tested and they were tested in dupli-cate.Competing interests The authors declare that they have no competing interests.Authors' contributionsMZ, QH, YH, OW, CC, and SD performed the experi-ments....
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Báo cáo y học: "Danaparoid sodium inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in rats" doc
... Thisstudy adds to the previous findings by suggesting that DA mayprevent LPS-induced lung injury by inhibiting cytokine and HMGB1 secretion.We demonstrated that IL-10 increased following the adminis-tration ... (Figure7).DA inhibits the IKK pathway and modulates NF-κBSince the NF-κB pathway plays a critical role in the secretionof cytokines, we measured the quantity of p50 and p65 in the nucleus. ... lungpathology and reduces mortality in endotoxin-induced systemicinflammation in a rat model. This effect may be mediated through the inhibition of cytokines and HMGB1.IntroductionDespite extensive investigation...
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Báo cáo y học: "Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener’s granulomatosis" pptx
... whether ANCA are directly involved in the pathogenesis of WG or are merely an epiphenomenon[10]. One of the unresolved issues is the inability toexplain the nonrandom, selected organ injury ... defines the WG vasculitis and the concurrent, seemingly random,nature of injury within ‘targeted’ organs [18]. Little isknown about the expression and distribution of PR-3 in the normal lung and ... frequent organ involved in WG [15]. In normal lung tissue, mainly pneumocytes type I and type II and just a few granulocytes and macrophagesexpress PR-3. We could detect the PR-3 mRNA expres-sion in...
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Báo cáo y học: "Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences" ppsx
... functionsA summary of Galaxy’s functionality and how Galaxy’s functionality compares to the functionality of two other genomic workbenches, GenePattern and Mobyle.Galaxy’s novel functionality includes ... histories, and workflow so that the study can be rerun in itsentirety [22]. To reproduce the analyses performed in the study, readers can copy the study’s his tories intotheir own workspace and rerun ... metagenomic pipeline that accepts NGS readsas the input and generate s phylogenetic prof iles as the output. The Galaxy Page for this study describes the analysesperformed and includes the study’s datasets,...
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Báo cáo y học: "Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum" ppt
... mucin-type O-glycosylation in animals [62]. Glycophosphorylation o f the hydroxya-mino acids threonine and serine may be less prevalent in D. purpureum owing to the much smaller size of itsglycophosphotransfer ... N-glycosylation.Cytoplasmic glycomeWhereas glycosylation occurs predominantly in the secretory compartments, formation of the precursors forthese pathways generally originates in the cytoplasm, ... made by a threestep biosynthetic pathway, in which a 12-carbon po lyke-tide is assembled by the StlB polyketide synthase, thensuccessively chlorinated by a c hlorinating enzyme, and methylated...
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Báo cáo y học: " Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo" pptx
... OAO,JB, and AWH grew and treated the cells and performed the cytotoxicity assays and immunoassays for virus titer. OAOprovided important conceptual input regarding the cyto-toxicity assays. GF ... patients against toxicity induced by radiation and chemotherapy. In an earlier study webriefly reported that the aminothiol WR1065 also inhibits HIV-1 replication in phytohemagglutinin (PHA)-stimulatedhuman ... used. DMW and VEWprovided essential information regarding the stability ofWR1065 in culture, and funding to share the cost of the amifostine synthesis. MCP wrote the protocols, calculated the data,...
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Báo cáo y học: "Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rat" pptx
... play an essen-tial role in reducing the severity of the I/R injury byinhibiting neutrophil adhesion in postcapillary venules and by decreasing microvascular constriction [20]. In ourstudy, ... at the 7 and 14 day reperfusion time-points. I/Rinjury of sciatic nerve has been shown to increase proin-lammatory cytokines which are primarly responsibledemyelinization after reperfusion in ... Preconditioning(IP)[9]. There are two distinct types of protection affordedby this adaptational reponse, i.e. acute and delayed pre-conditioning. The factors that initiate the acute and delayed preconditioning...
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Báo cáo y học: "Neuroendocrine tumors of the gallbladder: a case report and review of the literature" docx
... manuscript and was involved in datainterpretation. EO was involved in the conception and design of the study.FLT and VLT were involved in the care of our patient. VP was involved in histological ... Conse-quently, NETs can be found in any location of the body,although the sites most commonly affected are the gas-trointestinal and bronchopulmonary tracts, representingapproximately 67% and 25% ... carcinoids accordingto the low metastatic po tential of the neoplasia as wellas to the general insensitivity to traditional radiotherapy and chemotherapy in low-grade cancer disease.For many years,...
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Báo cáo y học: "Mycotic aneurysm of the inferior gluteal artery caused by non-typhi Salmonella in a man infected with HIV: a case report" pot
... pseudoaneurysms of the vessels feeding the gluteal region, including the inferior and superiorgluteal arteries and a persistent sciatic artery [8]. Aneur-ysms may compress the sciatic nerve, p roducing ... aneurysm of the femoral artery has beenreported in the case of an HIV-infected patient [7]. Wedescribe a mycotic aneurysm of the inferior glutealartery caused by NTS occurring in an adult Kenyanman ... immunod eficiency virus in Africa and otherresource-limited settings should be aware of the invasive nature of Salmonella infections and the potential foraneurysm formation in unlikely anatomical...
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