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... Public payer of healthcare costs (considers direct costs only); PRO = Pro vider (considers direct medical costs covered by the facility). 4 QALY = Quality-adjusted life years. 6 DALY = Disability-adjusted ... analysis as (0). 5 CEA = Cost Effectiveness Analysis. CUA = Cost Utility Analysis. CBA = Cost Benefit Analysis. 6 SSA = Sub-Saharan Africa. 7 ART = antiretroviral therapy. 8 VCT = volunt...

Ngày tải lên: 13/08/2014, 11:22

... hipermodified base Y3 7 (wybutine) (Figs 6 and 7). Also other amino- glycosides, as kanamycin A, neomycin B and a synthetic neomycin-neomycin dimer have been shown to induce fragmentation of tRNA Phe at Y3 7 ... of amikacin; dG, 2¢-deoxyguanosine; 8-oxo-dG, 7,8-dihydro-8-oxo-2¢- deoxyguanosine; ESI, electrospray ionization; MS/MS, tandem mass spectrometry; D, dihydrouridine; Y, wybutosine....

Ngày tải lên: 21/02/2014, 01:21

... peroxidases, Leu2, Tyr7, Pro12, Ile17, Phe41, Gly48, Glu64, Gly76, Phe77, Lys84, Glu88, Pro92, Val95, Ala98, Gly114, Pro115, Asp125, Phe152, Asp161, Leu166, Gly168, Gly173, Arg183, Gly242, Leu250, ... purification A. thaliana seeds, ecotype Columbia were kindly provided by F. Floto, and cell suspension culture by O. Mattsson, both at the Department of Plant Physiology, University of Copenhagen...

Ngày tải lên: 21/02/2014, 01:21

... (4-hydroxy- 3-methoxyphenyl-b-hydroxypropionyl-CoA) into vanillin [28]. An other well known example is trans-o-hydroxy- benzylidenepyruvate hydratase/aldolase [29,30] (also known as is 2¢-hydroxybenzalpyruvate ... enoyl-CoA hydratase/ aldolase [26]; (B2) trans-o-hydroxybenzylidenepyruvate hydratase/al- dolase [29]; (B3) trans-2-carboxybenzalpyruvate hydratase/aldolase [32]; (C) 6-hydroxy-2-ke...

Ngày tải lên: 21/02/2014, 01:21

... identified by thin-layer chromatog- raphy, immunologically and by high-performance liquid chromatography. The biological activity of (2–5)A oligo- mers was verified by inhibition of the protein synthesis ... immediately frozen (Ôcrude extractÕ). (2–5)A synthetase assay (2–5)A synthetase activity in crude extracts was d etermined after binding of the enzyme to a positively charged nylon membrane...

Ngày tải lên: 21/02/2014, 15:20

... endothelial lipase [1,2]. The primary function of LPL is triglyceride hydrolysis in triglyceride-rich lipoproteins, such as chylomicron and very low density lipoprotein (VLDL) particles, which ... the MARKIT-F LPL kit, and chromatography fractions were analyzed by Western blotting with LPL polyclonal antibody 7640 (B). Fig. 2. Heparin affinity of wild-type and basic amino acid–substituted LPL....

Ngày tải lên: 21/02/2014, 15:20

... discussed. Keywords: caa 3 oxidase; cytochrome c oxidase; UV/VIS- spectroscopy; FT-IR-spectroscopy; Thermus thermophilus. Cytochrome c oxidase is the terminal enzyme of the respiratory chain in ... pathways are necessary for the catalytic activity, but different residues may be involved. In an important step for the understanding of the essentials for cytochrome c oxidase activity and coupled...

Ngày tải lên: 21/02/2014, 15:20

... the transition state by hydrogen bonding to the )1 N-acetyl carbonyl oxygen atom. This h ydrogen bond stabilizes the partially negative charge on the carbonyl oxygen, thereby facilitating Fig. ... of Tyr183 in catalysis In previous crystallographic studies it was shown that the hydroxyl side chain of Tyr183 is within hydrogen bonding distance of the N-acetyl carbonyl oxygen of the sugar resid...

Ngày tải lên: 22/02/2014, 04:20

... variants produced by p26-ND60 and p26-alpha were pr esent but recognized poorly by antip26 antibody. To determine if recognition of p26-ND60 and p26-alpha encoded polypeptides by antibody to p26 was ... and have no chaperone-like activity. FEBS Lett. 433, 228–232. 23. Young, L S., Yeh, C H., Chen, Y M. & Lin, C Y. (1999) Molecular ch aracterization of Oryza sativa 16.9 k Da h eat s hoc...

Ngày tải lên: 22/02/2014, 04:20

... from the s oluble f raction b y affinity chromatography using amylose resin. In vitro kinase assays showed that the autophosphorylating ability o f PknA is strictly magnesium/manganese-dependent, ... prokaryotes usually uses His kinases, which autophosphorylate at histidine residues [2]. In eukaryotes, such signalling pathways are mediated by Ser/Thr or Tyr kinases, which autophosphorylate .....

Ngày tải lên: 22/02/2014, 04:20