... oxidase enzyme system [16]. Cimetidineincreases the plasma levels of theophylline, warfarin,metronidazole, imipramine, triazolam, diazepam, phenytoin,lidocaine, quinidine, nifedipine and propranolol ... [4,19–22]. Furthermore, drugbinding with sucralfate can reduce the effects of warfarin,phenytoin, digoxin, quinidine [23,24] and the fluoroquino-lones ciprofloxacin and norfloxacin [25].AntacidsAntacids ... protecting the gastric mucosa or increasing the intragastric pH. The principal means of directly protecting the gastric mucosa is the use of sucralfate. Although the potential protective effectof...