Báo cáo y học: "The inflammation–coagulation axis as an important intermediate pathway in acute lung injury" pptx
Báo cáo y học: "The inflammation–coagulation axis as an important intermediate pathway in acute lung injury" pptx
... coagulation and fibrinolysispredict mortality in acute lung injury. Crit Care 2008, 12:R41.2. Dinarello CA, Gelfand JA, Wolff SM: Anticytokine strategies in the treatment of the systemic inflammatory ... activated protein C significantly diminished pulmonaryinflammation in a murine model of intranasal lipopoly-saccharide-induced ALI/ARDS [14,15]. In conclusion, bronchoalveolar inflammation and coagulationactivation ... factor–activatedfactor VII pathway completely abrogated intrapulmonary fibrindeposition in patients with ARDS [10]. In association withenhanced fibrin production, fibrinolytic activity is depressed in bronchoalveolar...
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Báo cáo y học: "Advanced radiological work-up as an adjunct to decision in early reconstructive surgery in brachial plexus injuries" pptx
... between the clinical findings andradiological findings of every individual spinal nerveroot on one hand and the intraoperative findings on theother hand was estimated by cross tabulation and calcu-lation ... The interpretationof kappa values was done according to the method pro-posed by Landis [13]. A 2-way contingency table wasgenerated comparing the cl inical findings and radiologi-cal findings ... diagnostic accuracy of radiological findings was 88% compared with 65% for the clinical findings. Theconcordance between the radiological find ings and the intraoperative findings was substantial (К...
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Báo cáo y học: "Effects of monoclonal anti-PcrV antibody on Pseudomonas aeruginosa-induced acute lung injury in a rat model" ppt
... murine monoclonal anti-PcrV antibody Mab166 on acute lung injury induced by Pseudomonas aeruginosa were analyzed in a rat model.Methods: Lung injury was induced by the instillation of P. aeruginosa ... weighed and homogenized separately for water todry weight ratio measurement and radioactivity counts.Measurement of lung injury Lung injury was quantified in two different ways, as previ-ously described ... 1998,62:379-433.12. Wiener-Kronish JP, Frank DW and Sawa T: Mechanisms of lung epithelial cell Injury by acute by Pseudomonas aeruginosa. In Molecular biology of acute lung injury Edited by: Clark RSG, Carcillo...
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Báo cáo y học: " Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenz" pptx
... this system has good representation of analytes forinflammatory cytokines, anti-inflammatory cytokines, Th1cytokines, Th2 cytokines, Th17 cytokines and chemokines,allowing for the testing of ... of regulatorycytokines in the serum of severe and mild patients. Addition-ally, interferon α, adiponectin and leptin were measured byusing an enzyme-linked inmuno adsorbant assay (ELISA) fromR&D© ... respiratory disease caused by nvH1N1infection. Alternatively, an increase in Th-1 and Th-17cytokines may reflect a vigorous antiviral host response neces-sary for clearance of virus during severe...
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Báo cáo Y học: The mitochondrial-lysosomal axis theory of aging Accumulation of damaged mitochondria as a result of imperfect autophagocytosis ppt
... stability of lysosomal membranes, resulting in leak of avariety of hydrolytic enzymes into the cytosol. Such lysosomal enzymesmay directly activate Bid, pro-caspases, or lytic cytosolic pro-enzymessuch ... lysosomal enzymes, and as lipofuscin-containing lysosomes act as sinks for newly synthesizedenzymes, they are not available to functional (lipofuscin-free)lysosomes. The diminished ability to degrade ... oxidatively-damaged and dysfunctional macromolecules and organ-elles, as well as lipofuscin inclusions. In this review, wefurther develop the idea that mitochondrial and lysosomalinjury and dysfunction play...
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Báo cáo y học: "The instantaneous helical axis of the subtalar and talocrural joints: a non-invasive in vivo dynamic study" ppsx
... Doral MN: Anatomic factors and biomechanics in ankle instability. Foot Ankle Clin 2006, 11:451-463.2. Daniels T, Thomas R: Etiology and biomechanics of ankle arthritis. Foot Ankle Clin 2008, ... Sheehan FT, Zajac FE, Drace JE: Using cine phase contrast magnetic resonance imaging to non-invasively study in vivo knee dynamics. J Biomech 1998, 31:21-26.28. Sheehan FT: The Finite Helical Axis ... Sheehan, The instantaneous helical axis of the subtalar and talocrural joints: a non-invasive in vivo dynamic study Journal of Foot and Ankle Research 2010, 3:13Sheehan Journal of Foot and Ankle...
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Báo cáo Y học: The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider pptx
... omesin and those o f PG-1 a nd androctoninsuggest that gomesin e xerts antibacterial activity by inter-acting with the cytoplasmic bacterial membrane.Differences in t he distribution of hydrophilic ... years, a growing opinion arguesthat only the maintenance of the hydrophobic-hydro philicbalance in those highly cationic peptides is the key point foractivity. This viewpoint has to be t aken ... introduced as constraints. A final set of50 structures was then generated in a fin alDYANArun f rom an input file taking into account the t otal set of constraints.Twenty out of these 50DYANAstructures...
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Báo cáo Y học: The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils doc
... recombinant cytosolic phox proteins, Drs Anne-Christine Dianoux and Marie-Jose´Stasia for anti S100A9 antibodies,and Dr Je´roˆ me Garin for protein analysis. This work was supported byfunds ... sequencing, using Edman degra-dation. As S100A9 has a blocked N-terminal amino acid,analysis of the protein was carried out by mass spectrometry.The protein band corresponding to S100A9 in the ... S100A9.Assay of NADPH oxidase activity afteroxidase activationThe dormant NADPH oxidase of neutrophil membraneswas activated by mixing neutrophil plasma membranes andthe recombinant cytosolic...
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Báo cáo y học: "The psychological well-being of children orphaned by AIDS in Cape Town, South Africa" pptx
... than non-orphans. Makame etal. (2002) in urban Tanzania, used a scale based on theRand Inventory and items from the Beck Depressioninventory, and found increased internalising problemsand ... for orphans, and into the effects of differing carearrangements, as rising orphan numbers may lead to an increase in child-headed households and streetchildren.Annals of General Psychiatry 2006, ... substantially raisedprobability of independently diagnosed psychiatric disor-ders (Goodman 2001). The SDQ has been translated into51 languages, and extensively validated in many Westernand...
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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... notablycontain ankyrin repeat motifs containing the asparagineresidue hydroxylated by FIH [31]. Another target, identifiedonly recently as an FIH substrate and also possessing an ankyrin repeat ... namely NF-κB and HIF.Mimicking hypoxia by treatment of cells with small interferingRNA against PHD-1 or PHD-2 or the pan-hydroxylaseinhibitor dimethyloxalylglycine (a 2-OG analogue, and an inhibitor ... characterized as oxygenasesgoverned by oxygen, 2-oxoglutarate (2-OG), iron (Fe2+) andascorbic acid (collectively termed HIF prolyl hydroxylasedomain [PHD]-containing enzymes), and factor inhibiting...
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