Báo cáo y học: "Protein C as a surrogate end-point for clinical trials of sepsis" docx
Báo cáo y học: "Protein C as a surrogate end-point for clinical trials of sepsis" docx
... (up to 7 days), and the efficacy of theseinfusions for normalization of protein C levels. We agree thatthese are clinical scenarios in which protein C may have value as a surrogate end-point. ... The Cardiac Arrhythmia Suppression Trial (CAST) Investigators:Preliminary report: effect of encainide and flecainide on mor-tality in a randomized trial of arrhythmia suppression aftermyocardial ... Vasan RS: Biomarkers of cardiovascular disease: molecularbasis and practical considerations. Circulation 2006, 113:2335-2362.8. Vangerow B, Shorr AF, Wyncoll D, Janes J, Nelson DR, ReinhartK:...
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Báo cáo Y học: Protein methylation as a marker of aspartate damage in glucose-6-phosphate dehydrogenase-deficient erythrocytes docx
... ÔExtra andintracellular nucleotide and nucleoside: chemical signals, metabolicregulators and potential drugsÕ and ÔHyperhomocysteinemia as a cardiovascular risk factor: biochemical mechanism(s)Õ.REFERENCES1. ... different erythrocyte age/density fractions obtained byisopycnic centrifugation on a Percoll gradient. Methyl esterification inintact erythrocytes was assayed by incubating them in the presence of [3H]methionine ... Ôbuoyant fractionÕ and ÔdensefractionÕ. Pyruvate kinase (PK) activity was measured, as a cell-age marker, in individual erythrocyte populations.Diagnostic evaluation and identification of the G6PDgene...
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Báo cáo y học: " Toxoplasmosis presenting as a swelling in the axillary tail of the breast and a palpable axillary lymph node mimicking malignancy: a case report" potx
... present a case of toxoplasmosis that presented as a swelling in the axillary tail of the breast with a palpable axillary lymph node which mimicked breast cancer.Case presentation: A 45-year-old ... cases have been reported [3-5]. We present a case of toxoplasmosis that presented as an axillary tail(breast) mass and a palpable axillary lymph node whichmimicked breast cancer.Case presentation A ... 1997,89:446-448.doi:10.1186/1752-1947-5-348Cite this article as: Siriwardana et al.: Toxoplasmosis presenting as a swelling in the axillary tail of the breast and a palpable axillary lymphnode mimicking malignancy: a case report....
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... late-onsetFinnish type 1 diabetes subjects. Immunogenetics 2010, 62:101-107.36. Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K,Shimada A, Uga M, Kurihara S, Kawabata Y, ... Conversely, thisdefect may not be an absolute requirement and may beabsent from many of the cases. A more refined approach,based on genetic-based selection of clinically stratified T1D subjects, ... 48:6-11.19. Bernasconi A, Marino R, Ribas A, Rossi J, Ciaccio M, Oleastro M, Ornani A, Paz R, Rivarola MA, Zelazko M, Belgorosky A: Characterization of immunodeficiency in a patient with growth...
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Báo cáo y học: "HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis" potx
... protocoldesigned for this study, which included epidemiological anddemographic data, medical history, clinical features, physicalexamination, laboratory data (including tests for rheumatoidfactor and antinuclear ... potential arthritogenic polymorphism of MICA (majorhistocompatibility complex class I chain-related gene A) ,called MICA -A9 , has been associated with PsA risk independ-ently of HLA-Cw6 [10].To ... psoriasis were con-secutively recruited at random from the general database of the rheumatology and dermatology departments of a tertiarycare hospital. In our health care context, psoriatic patients...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... Hasegawa, J., Yoshida, T., Yamazaki, T. & Sambongi, Y. , Yu, Y. , Igarashi, Y. , Kodama, T., Yamazaki, K., Kyogoku, Y. &Kobayashi, Y. (1998) Solution structure of thermostable cyto-chrome ... & Ferguson, S.J. (1996) Alteration of haem-attachment and signal-cleavage sites for Paracoccusdenitrificans cytochrome c 550probes pathway of c- type cyto-chrome biogenesis in Escherichia ... produced as a holopro-tein in the E. coli cytoplasm similar to the case of HT c- 552[26]. Although the cytoplasmic holo-(TT c- 552) has thesame function and spectra as the authentic one, thecytoplasmic...
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Báo cáo y học: "Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)" pptx
... each category. Patients were included if they had a baseline PC measure. Day 4 PC was classified as end of infusion. If day 4 measurement was not availa-ble, last observation carried forward ... greater than 50%. The PTEE for cardiovascular SOFA was 41%. PC predicts cardiovascularchanges downstream, and so it is expected that the cardiovas-cular SOFA would be a reasonable surrogate. However, ... correlated with clinical outcomeBaseline values of six laboratory and five clinical measureswere evaluated as potential predictors of 28-day mortality. Toallow comparisons across measures, the cut-off...
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Báo cáo Y học: Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin a-sarcin potx
... replace Arg121 with Lys (R121K) or Gln(R121Q) as described previously [20,30–32]. The muta-genic primers used were 50-CCTGGCCCGGCGAAGGTCATCTACACC-30 for R121K and 50-CCTGGCCCGGCGCAGGTCATCTACACC-30 for ... Role of Arg121 on cytotoxicity of a- sarcin (Eur. J. Biochem. 268) 6193Arginine 121 is a crucial residue for the speci c cytotoxic activity of the ribotoxin a- sarcinManuel Masip, Javier Lacadena*, ... [16] and RNase T1 [17] display an identicalarchitecture and connectivity of the secondary structureelements in the three proteins. The catalytic mechanisms of a- sarcin and RNase T1 are similar...
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Báo cáo y học: "B cells as a therapeutic target in autoimmune disease" doc
... Bernasconi NL, Traggiai E, Lanzavecchia A: Maintenance of serological memory by polyclonal activation of humanmemory B cells. Science 2002, 298:2199-2202.26. Matsumoto I, Maccioni M, Lee DM, Maurice ... drug-resistant human B cell lymphomas to thecytotoxic effect of CDDP, VP1- and toxins [abstract]. FASEB J1995, 9 :A2 06.8. Kosmas C, Stamatopoulos K, Stavroyianni N, Tsavaris N,Papadaki T: Anti-CD20-based ... discovery of autoantibodies in chronic inflammatorydiseases initiated an era of clinical investigation and estab-lished the foundation of modern clinical immunology. Theoriginal descriptions of antinuclear...
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Báo cáo y học: "Rheumatoid arthritis as a hyper-endoplasmic reticulumassociated degradation disease" pdf
... ERAD system eliminates unfolded proteins thatCommentaryRheumatoid arthritis as a hyper-endoplasmic reticulum-associated degradation diseaseSatoshi Yamasaki1, Naoko Yagishita1, Kaneyuki ... Japan2Rheumatology, Immunology and Genetics Program, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Kanagawa, JapanCorresponding author: Toshihiro Nakajima, nakashit@marianna-u.ac.jpPublished: ... between syno+/+and syno+/−mice. No advancedsynovial cell hyperplasia was detected in CIA-syno+/−mice,even though inflammatory cell infiltration was clearly observedin them. Detailed analysis...
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