Báo cáo y học: "Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo" pot

... reducing vascular leak and acute inflam- mation in lung injury are needed. Cell-membrane phospholipids and phospholipids present in circulating lipoproteins may undergo oxidation by lipoxygen- ases ... We recently demon- strated that intravenously administered OxPAPC protects against tissue inflammation, lung vascular barrier dysfunction, and inflammatory cytokine product...

Ngày tải lên: 13/08/2014, 10:20

... airway inflammation via recruitment of CD8+ T cells into the airways to trigger the release of proinflammatory cytokines including TNFα and IL-4 and inhibit the production of antiinflammatory ... regulated by a variety of chemokines (5). The expression of distinct chemokine receptors on infiltrating cell populations, especially on lymphocytes and eosinophils which are highly impl...

Ngày tải lên: 12/08/2014, 14:20

... (the aminoglycoside, kanamycin, the a minocyclitol glycoside, streptomycin, t he penicillins, ampicillin and penicillin G, the aminocyclitol, spectinomycin, tetracycline and Cl-tetracycline, and ... binding equation, giving an inhibition constant, K i , for splicing inhibition as described previously [31]. RESULTS Erythromycin, Cl-tetracycline and streptomycin inhibit nuclear splicing...

Ngày tải lên: 21/02/2014, 15:20

... with thickening of the lining layer (or intima) and infiltration of the sublining layer, mainly by macrophages and lymphocytes [1]. In addition, the fluid- filled joint cavity contains numerous ... severe as in RA samples, and noninflamed sites showed a normal intimal layer and no leukocyte infil- trates. Chemokine binding to macrophages To examine in situ binding of chemokines,...

Ngày tải lên: 09/08/2014, 03:24

... participated in study design, and drafted the initial manuscript. LP assisted in gen- otyping some of the control individuals. SH aided in recruit- ment and clinical phenotyping of PsA patients. PR and ... cleaned and spotted onto a Spectro- Chip (Sequenom Inc.). The chips were scanned using a MT Analyzer (Bruker Daltonics Inc., Billerica, MA, USA) and the resulting spectra we...

Ngày tải lên: 09/08/2014, 07:20

... being present per standard-deviation increase in vitamin C/vitamin E intake before and after adjusting for energy intake, age, gender, body mass index, and tibial cartilage volume. c Change in ... 0.66 a Change in tibial cartilage volume (mm 3 ) per standard-deviation increase in vitamin C/vitamin E intake before and after adjusting for energy intake, age, gender, body mass in...

Ngày tải lên: 09/08/2014, 10:20

... salts, penicillamine, and cyclosporine – are no longer commonly used. Thus, the finding of reduced GH half-life observed in this study may be more prominent in earlier disease and in patients who ... Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 1994, 93:2379-2386. 2. Pincus T, Sokka T, Wolfe F: Pre...

Ngày tải lên: 09/08/2014, 10:20

... produced mainly in white adipose tissue and may be the linkage between obesity and insulin resistance. In humans, the role of resistin is not yet fully established. There is evidence that resistin has ... populations [6-8]. In humans, resistin is expressed in inflammatory cells, leukocytes, and macrophages [9] and has the potency of inducing produc- tion of interleukin (IL)-6...

Ngày tải lên: 09/08/2014, 10:22

... in fibroblast-like synoviocytes, as seen by ELISA analysis on culture supernatant. The authors concluded that infiltrating T lymphocytes and myeloid cells are the main sources of NGF in the inflamed ... in the synovial tissue and on chondrocytes. The importance of neurotrophins in joints should be further studied, including examinations on the efficacy of interfering with their ef...

Ngày tải lên: 09/08/2014, 14:22

... CGIs are typically unmethylated [25,26], notwithstanding many target CpGs in them. It is likely that trans-acting regulators are actively recruited to promoter CGIs to maintain this region in a nucleosome -and ... the three marks present in internal and terminal exons. Materials and methods Measurement of nucleosome occupancy and DNA methylation H2A.Z-containing nucleosomes in...

Ngày tải lên: 09/08/2014, 20:22