... cranialradiotherapy included very young ch ildren, and in many the adverse effects of radiotherapy were strongly asso-ciated with the younger age groups[10,14,18,24,25,29,30]. Since radiotherapy is ... 4:42http://www.jhoonline.org/content/4/1/42Page 4 of 12morbidity regardless of which of these randomised CNS-directed therapies they received. This has previouslybeen suggested by smaller studies [33,36], a meta-an aly-sis [21], ... psycho-metric study aimed to compare prospectively the neuro-cognitive effects of three different types of CNS-directedtherapy (HDM vs. IT MTX an d HDM vs. XRT). The studyofalargecohortofchildrenrandomlyallocatedto...