Báo cáo y học: "Bench-to-bedside review: Mechanisms and management of hyperthermia due to toxicity" doc

... Successful management of PCP toxicity relies on the early recognition and aggressive management of hyperthermia with passive and active cooling techniques. Given the pathophysiology of PCP toxicity, ... cyproheptadine followed by 2 mg every two hours if symptoms continue is generally recommended. Many cases of serotonin syndrome typically resolve within 24 hours after initia...

Ngày tải lên: 13/08/2014, 10:20

... will need to be randomized into an early therapy arm and subjected to the risks of RRT. Thus, robust biomarkers and/ or clinical predictors of the course of AKI are needed before such a study can ... patients to the risks of hemodialysis who would recover renal function with conservative therapy alone and that exposure to hemodialysis might delay recovery of renal funct...

Ngày tải lên: 13/08/2014, 08:20

... U A 3´ 5´ U C A U A U A A Y R G C C C G G A U A P3 AA U U Y R R Y Y Y C Y R R R R G Y Y P1 Y Y A U R U R R Y R U R discriminator base P2 P2 P5 P1 G A A G G C G G G G Y P2a A R A G G U A G C R G A A Y R A R RR R P3 G C A P4 Lysine aptamer Y Y G P2b P2c R Sarcin/Ricin loop ... 3´ K-turn P3 Y G A A G C C U R G G C C R * 1 * 2 * Y R U Y R G C CG G A A A A A A A U U U U...

Ngày tải lên: 14/08/2014, 08:20

... disrupted. They are also part of the oral flora and can cause peri-oral infection. Bacteroides contribute to development of a synergistic infection by reducing phagocytosis by polymorphs and through ... suspicion, an early diag- nosis, and prompt institution of effective antimicrobial therapy to decrease the mortality and morbidity associ- ated with septic pulmonary embolisa...

Ngày tải lên: 11/08/2014, 10:23

... production of superoxide species [114]. Peroxy- nitrite, superoxide, and other reactive oxygen species lead to inhibition of the glycolytic enzyme glyceraldhyde phosphate dehydrogenase and mitochondrial ... acute pathophysiology of this disease. A better understanding of the dynamic process of hematoma growth, importance of inflammation triggered by coagulation and product...

Ngày tải lên: 13/08/2014, 11:23

... patient was symptom-free at one-year follow-up. Long-term follow-up of our patient will help to ascertain the safety profile of the approach we employed. System- atic work-up and follow-up of patients ... publication of this case report and any accompanying images. A copy of the written consent is available for review by Editor-in-Chief of this journal. Abbreviations CT: com...

Ngày tải lên: 11/08/2014, 12:20

... stress conditions and the augmentation of an inflammatory state in pathophysiology, regulated by the oxygen- and redox-sensitive pleiotropic cytokines. Keywords: apoptosis, cytokine, development, ... formation of ROS and abrogates the cytokine-dependent seque - lae. Cytokines act as major participants in the pathophysiology and aggravation of the clinical symptoms of respirat...

Ngày tải lên: 12/08/2014, 18:20

... ratio of arterial partial pressure for oxygen to the fraction of oxygen in the inspired air. 240 lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome ... induces the release of proinflammatory cytokines into the airspaces and bloodstream, neutrophil infiltration into the lung, and the activation of lung macrophages [16]. Tremblay an...

Ngày tải lên: 12/08/2014, 19:21

... intracellular stores of GSSG, a potent inhibitor of NF-κB transcription factor DNA binding. The pathway leading to the formation of GSH by the action of γ-glutamylcysteine synthetase (GCS) is blocked by L-buthionine-(S,R)-sulfoximine ... stabilization of IκB-α, without significantly affecting its phosphorylation. Anti-inflammatory cytokine-mediated oxidant injury Another anti-inf...

Ngày tải lên: 12/08/2014, 19:21

... by hypoxia and by cytokines. To identify the cellular mechanisms in control of tubular VEGF production, the effects of hypoxia and IL-1β on VEGF mRNA levels, on VEGF secretion and on activity ... irreversible inhibitor of γγ -glutamylcysteine synthetase, augments LPS- mediated pro-inflammatory cytokine biosynthesis: evidence for the implication of an I κκ B- αα /NF- κκ B in...

Ngày tải lên: 12/08/2014, 19:21