Báo cáo y học: "Spatiotemporal regulation of the cough motor pattern" ppsx
Báo cáo y học: "Spatiotemporal regulation of the cough motor pattern" ppsx
... Abstract The purpose of this study was to identify the spatiotemporal determinants of the cough motor pattern. We speculated that the spatial and temporal characteristics of the cough motor pattern would ... spontaneously breathing cats [5]. These observations indicate that the regulation of cough motor pattern is fundamentally different than that of breat...
Ngày tải lên: 13/08/2014, 10:20
Báo cáo Y học: Differential regulation of the Fe-hydrogenase during anaerobic adaptation in the green alga Chlamydomonas reinhardtii pot
... stress by redirect- ing t he synthetic machinery towards the synthesis of s ome enzymes involved in glycolysis or sugar-phosphate metabolism [54]. HydA belongs to a new class of Fe-hydrogenases HydA ... another regulation system for the expression of the hydrogenase. At the m oment it is not clear if this effect rests upon a new synthesis or a higher stability o f the hydA m...
Ngày tải lên: 08/03/2014, 22:20
Báo cáo y học: " Down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis" docx
... and 5(C) respectively. Discussion In the present study we analyzed, for the first time in the literature, the expression profiles of ING4 in the experi- mental model of pulmonary fibrosis as well ... angiogenesis. The aim of our study was to investigate the role of ING4 in the pathogenesis of pulmonary fibrosis both in the bleomycin (BLM)-model and in two different...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: " Down regulation of the high-affinity IgE receptor associated with successful treatment of chronic idiopathic urticaria with omalizuma" pot
... Interestingly, a toler- ance to the sedative effects of d iphenhydramine devel- oped after a few days of scheduled treatment as has been suggested by other authors [2]. During the course of the first ... first 14 days of treatment, there was an approximate 80% decrease in the expression of the high affinity IgE receptor that was main- tained throughout the duration of...
Ngày tải lên: 13/08/2014, 13:22
Báo cáo Y học: Functional analysis of the rat bile salt export pump gene promoter Regulation by bile acids, drugs and endogenous compounds potx
... immediately upstream of the TATA box in the p-126 minimal promoter construct completely abolished the stimulation of luciferase activity by CDCA in HepG2 cells (Fig. 6). Interestingly CDCA reduced the activity of ... activity of the mutant m-126 Luc even below that of the wild-type p-126 Luc. Analysis of the binding affinity of the putative FXRE site for the orp...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt
... MMP-13) have the unique ability to cleave the triple helix of collagen, thereby allowing the chains to unwind; the chains then become susceptible to further degradation by other MMPs. Recently, MMP-8 ... the MMP promoters, except MMP-2. The number of these sites and their location within a given pro- moter vary among the MMP family members, and these vari- ations influence...
Ngày tải lên: 09/08/2014, 03:24
Báo cáo y học: "Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts" docx
... specifically increased the steady-state mRNA levels of MMP-1 and enhanced the binding of c-Jun to the promoter of MMP-1. Furthermore, disruption of the proximal AP-1-binding site in the promoter of ... 12:R73 http://arthritis-research.com/content/12/2/R73 Page 12 of 14 of SSc dermal fibroblasts [39]. It is therefore likely that the effect of bortezomib on type I c...
Ngày tải lên: 12/08/2014, 12:20
Báo cáo y học: " Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear impo" doc
... inde- pendently of the importin a/b pathway, and SV40T NLS, which is imported to the nucleus by the importin a/b pathway, were employed as controls [30,31]. We first confirme d that the nuclear import of the ... is selectively and efficiently inhibited by HIC and is not the result of a ge neral block of nuclear import pathways or obstruction of the NPC. To further diss...
Ngày tải lên: 13/08/2014, 01:20
Báo cáo y học: "Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions" doc
... conception and design of the study and the acquisition, the analysis and the interpretation of the data. AP participated in the conception and design of the study and the acquisition of the data. AS participated ... participated in the conception and design of the study, the acquisition, the analysis and the interpretation of the data, the statistic...
Ngày tải lên: 13/08/2014, 13:20
Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"
... over the progression of cancer; and the second question is whether the PR domain alone possesses anticancer activity. In this study, we quan- titatively analyzed the mRNA expression level of ... research grant from the Cancer Research Society of Canada. W. Sun would also like to acknowledge the College of Phar- macy and Nutrition, University of Saskatchewan for the...
Ngày tải lên: 25/10/2012, 11:15