Báo cáo y học: " Evolution of the uniquely adaptable lentiviral envelope in a natural reservoir host" potx

... [71], SIVsm appears to be highly glycosylated in naturally infected SMs. Presumably, continually evolving antibody responses in these natural hosts maintain a highly glyco- sylated surface protein, albeit ... fragment spanning the V1–V2 hypervariable region of envelope. The gag region was amplified using shortgagF1 (5'TTAAGTCCAAGAA- CATTAAATGC-3') and shortgagR (5&apo...

Ngày tải lên: 13/08/2014, 09:21

... 7:94 http://www.retrovirology.com/content/7/1/94 Page 2 of 7 Figure 3 Analysis of synonymous and non-synonymous mutation in the plasma virus and proviral compartments. Shown are p-distance values for plasma (A) and proviral (B) sequences as ... Berkley AM, Sacha JB, Cogliano-Shutta NA, Lloyd M, Roby G, Kwan R, McLaughlin M, Stallings S, Rehm C, O’Shea MA, Mican J, Packard BZ, Komoriya...

Ngày tải lên: 13/08/2014, 01:20

... – was originally estimated using the least square means obtained from an analysis of covariance with study and baseline values as covariates. Table 1 Patient demographics and baseline disease ... OA pain, patient's global assessment of disease activity, and functional impairment. We present data on patient satisfaction according to PASS during and at the end of the study peri...

Ngày tải lên: 09/08/2014, 10:20

... neutralization of the 6-month viral isolate by baseline infant plasma (i00) was 68% compared to 90% by baseline maternal plasma (m00) at the same dilution (1:20), indicating that only a subset of ... Zam- bian mother and infant pair (MIP 1157) for more than 6 years. The mother and child are anti-retroviral naïve and remain clinically asymptomatic. Infant 1157 was infected in ute...

Ngày tải lên: 13/08/2014, 09:21

... (MS) Glyoxylate  H 2 O  acetyl-CoA ! malate  CoASH MS (EC 4.1.3.2) catalyzes the transfer of the acetyl moeity of acetyl-CoA to glyoxylate to yield L -malate. The glyoxy- somal enzyme has been isolated ... sequence diversity [70]. Isocitrate lyase (ICL) Isocitrate ! succinate  glyoxylate ICL (EC 4.1.3.1) catalyzes the cleavage of isocitrate into succinate and glyoxylate. Th...

Ngày tải lên: 22/02/2014, 04:20

... involved in the study. JPM partici- pated in the study design and coordination. BB supervised the study, and participated in its design and coordination. All authors read and approved the final manuscript. Acknowledgments We ... electroporation. The cultures were inspected regularly for the emergence of revertant viruses, using CA-p24 ELISA and/or the appearance of syn...

Ngày tải lên: 13/08/2014, 13:20

... Kurokawa K, Yamashita A, Nakata M, Tomiyasu Y, Oka- hashi N, Kawabata S, Yamazaki K, Shiba T, Yasunaga T, et al.: Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic ... [9]. Although S. agalactiae normally behaves as a commensal organism that colonizes the genital or gastroin- testinal tract of healthy adults, it can cause life threatening in...

Ngày tải lên: 14/08/2014, 07:21

... individuals included in the cohort was not included in the analysis. Of the available samples, genotyping was attempted in 1,600 and was successful in 1,589 in the current study. Of all the controls ... dis- crimination assay as described previously [9]. Duplicate sam- ples and negative controls were included across the plates to ensure accuracy of genotyping. In...

Ngày tải lên: 09/08/2014, 08:22

... dorsal plating [5-7]. Conclusion High-energy traumas to the hand and wrist can result in ipsilateral and even bilateral fractures of the radius and scaphoid, and initiation of an early rehabilitation ... injuries. Case presentation: A patient with bilateral comminuted, displaced distal fractures of the radius and bilateral fractures of the scaphoid was treated via internal...

Ngày tải lên: 11/08/2014, 23:21

... muscle-type nAChRs [17]. In addition, we have found that NNK activates the Raf-1/MAP kinase pathway result- ing in phosphorylation of c-myc [10]. This activation was inhibited by alpha-bungarotoxin. ... chronic treatment of pregnant monkeys with nicotine caused a pronounced upregulation of the α7 nAChR in the lungs of the newborns [24]. Together these data indicate tha...

Ngày tải lên: 12/08/2014, 18:21