Báo cáo y học: " A peptide-loaded dendritic cell based cytotoxic T-lymphocyte (CTL) vaccination strategy using peptides that span SIV Tat, Rev, and Env overlapping reading frames" ppt

... CCCATATCCAACAGGACCCGGCACTGCCAACCAGAGAAGGCAAAGAAGGAGACGGTGGAGAAGGCGGTGGCAACAGCTCCTGGCCTTGGCAGATAGL22815 CCCATATCCAACAGGACCCGGCACTGCCAACCAGAGAAGGCAAAGAAGGAGACGGTGGAGAAGGCGGTGGCAACAGCTCCTGGCCTTGGCAGATA. A Y0 72902 CCCATATCCAACAGGACCCGGCACTGCCAACAAGAGAAGGCAAAGAAGGAGACGGTGGAGAAGGCGGTGGCAACAGCTCCTGGCCTTGGCAGATAG A Y0 72903 ... CCCATATCCAACAGGACCCGGCACTGCCAACAAGAGAAGGCAAAGAAGGAGACGGTGGAGAAGGCGGTGGCAACAGCTCCTGGCCTTGGCAGATAG A Y0 72903 CCCATATCCAACAGGACCCGGCACTGCCAACCAGAGAAGGCAAAGAAGGAGACGGTGGAGAAGGCGGTGGCAACAGATCCTGGCCTTGGCAGATAG A Y0 72904 CCCATATCCAACAGGACCCGGCACTGCCAACCAGAGAAGGCAAAGAAGGAGACGGTGGAGAAGGCGGTGGCAACAGATCCTGGCCTTGGCAGATAG A Y0 72907 ... CCCATATCCAACAGGACCCGGCACTGCCAACCAGAGAAGGCAAAGAAGGAGACGGTGGAGAAGGCGGTGGCAACAGCTCCTGGCCTTGACAGATAGM76764 CCCATATCCAACAGGACCAGGCACTGCCAACCAGAGAAGGCAAAGAAGGAGACGGTGGAGAAGGCGGTGGCAACAGCTCCTGGCCTTGGCAGATAGU86638 CATATCCAACAGGACCCGGCACTGCCAACCAGAGAAGGCAAAGAAGGAGACGGTGGAGAAGGCGGTGGCAACAGCTCCTGGCCTTGGCAGATAGM74949...

... distinguishes NeuAc (a2 ,6)Gal/GalNAcfrom NeuAc (a2 ,3)Gal/GalNAc [8], it is an extremely usefultool for the analysis of sialylated N- and O-glycans [9].SNA-I was originally isolated from elderberry bark whereit ... protein. Assays of the RNAN-glycosylase activity using ribosomes from both animal and plant origin as a substrate yielded identical results forrSNA-If and SNA-If. Both proteins de-adenylated rabbitreticulocyte ... with a mortar and pestle, taking care not to damage the seeds, and thetotal cellular RNA was then prepared as described by VanDamme & Peumans [14]. A cDNA library was constructedwith total...

... study,data and statistical analysis and interpretation. FR participated in the data anal-ysis. BHK and CD were responsible for writing the manuscript; MP, GB and CSsupervised the study. All authors ... grade and size and nodal status(the latter being negative for all patients in this study). AOLcalculates 10-year survival probability based on a patient'sage, tumor size and grade, tumor ... 11:R18http://genomebiology.com/2010/11/2/R18Page 3 of 18which may be interpreted as saying that, for any time t, theprobability was at least 71% that a patient who relapsed attime t had a risk score greater than...

... statistically significant for all anal-yses.Analysis of the apoptosis assays was undertaken using both parametric and non-parametric analysis methods.Parametric analysis was undertaken using ... cytometer. Data obtained by flow cytometry wasanalyzed by non-parametric t-test (Mann-Whitney test).An alpha level of 0.05 was considered statistically signifi-cant.Statistical analysisMicroarrays ... relevant cellulardynamics. We used a well-developed and validated geneexpression microarray to examine the dynamics of mRNAaccumulation and differences between adult and neonatalmonocytes in that...

... antigen presentation, referred to ascompensatory anti-inflammatory response syndrom e(CARS). Many argue that SIRS and CARS occur simul-taneously as a mixed antagonisticresponsesyndrome(MARS) ... ininflammatory parameters could indicate a n attenuationof SIRS and/ or CARS; however, they were not consis-tently accompanied by significant changes in infection and mort ality rates. Administation ... severity, but also onsepsis [28] or inflammatory parameters [16] as Nakoset al. [26] did when they only randomized patients afterascertaining immune paralysis by measuring the HLA-DR in bronchoalveolar...

... average resolution of the map is 2 cM, that is, about93 kb). In addition, many peaks may correspond to shortphysical regions that, by chance, have been framed by mark-ers and have shown at least ... fileAcknowledgementsWe thank Martial Marbouty, Marion Segalen, Bertrand Lachaise, ChristelleAdam, Laetitia Barrault, Véronique Noël, Laure Riffault, Véronique Henriot and Magally Torres-Leguisamón ... taken separately and together (maps B, V, and combined). They were all saturated and as the order of mark-ers in common was the same in maps taken pairwise, thecombined map will be the only...

... phosphatase-labelled streptavidin (1 : 1000). Con-trol assays were carried out in wells saturated with gelatin and gelatin hydrolysate used alone. Each assay was con-ducted in triplicate and the mean value ... G- and F-actins, promotes nucleation and both severs and caps actin filaments. Cofilin belongs toanother family of actin-binding proteins that also seversactin filaments and increases polymerization ... Proteolysed material wasanalysed by 15% SDS/PAGE. Molecular mass markers (lane 1), actin treated by EEDQ (lane 2), gelsolin fragment 159–193-actin complex treated byEEDQ (lane 3). (A) SDS/PAGE stained...

... teichoic acids, the anionic glycopolymerswhich are covalently bound to peptidoglycan and aresituated between other cell wall layers and at the cell surface.They impart a negative charge to the cell ... acidwith a disaccharide repeating unit fi6) -a- D-Glcp-(1fi4)-b-D-ManpNAc3NAcA-(1fi,ab-glucosylated polymer of3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid (Kdn), and a b-glucosylated ... pathogenicStreptomycessp.VKM Ac-2124Alexander S. Shashkov1, Larisa N. Kosmachevskaya2, Galina M. Streshinskaya2, Lyudmila I. Evtushenko3,Olga V. Bueva3, Viktor A. Denisenko4, Irina B. Naumova2and...

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... 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....

... trypan blue. Analysis wasperformed in triplicate wells and results are expressed as themean ± standard error (SE).Chemotaxis and checkerboard assays with RA synovial fluidChemotaxis was performed ... Nonomura Y, Kohsaka H, Nagasaka K, Miyasaka N: Gene transferof a cell cycle modulator exerts anti-inflammatory effects inthe treatment of arthritis. J Immunol 2003, 171:4913-4919.23. Nonomura Y, ... of the study and participated inits design and coordination. All authors read and approved thefinal manuscript.AcknowledgementsThe authors are supported by an Arthritis Foundation Arthritis...