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Báo cáo y học: " Inhibition of HIV derived lentiviral production by TAR RNA binding domain of TAT protein" pps

Báo cáo y học:

Báo cáo y học: " Inhibition of HIV derived lentiviral production by TAR RNA binding domain of TAT protein" pps

... on TAT activated LTR-Luciferase activity and specific TAR RNA binding by Tat- PFigure 6Inhibitory effect of Tat- P on TAT activated LTR-Luciferase activity and specific TAR RNA binding by Tat- P. ... monitored by MTT assay.BioMed CentralPage 1 of 11(page number not for citation purposes)RetrovirologyOpen AccessResearch Inhibition of HIV derived lentiviral production by TAR RNA binding domain ... investigated whether Tat- P's antiviral activity wasdue to specific binding to TAR- RNA by performing Tat- Pand TAR- RNA binding assays in vitro. Tat -TAR- RNA com-plexes were formed by mixing serial...
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Báo cáo y học: "Hepcidin induces HIV-1 transcription inhibited by ferroportin" pps

... absence of Tat, HIV- 1basal transcription is largely regulated by the Sp1 tran-scription factor [14,15]. Efficiency of transfection wasverified by co-expression of EGFP (Figure 1D). Basal,non -Tat- induced ... weanalyzed the activity of HIV- 1 promoters with inactiva-tion of Sp1 sites or deletion of NF-B sites [17]. Expres-sion of ferroportin w as associated with inhibition of theactivity of HIV- 1 ... Addition of hepcidin led to reduced inhibition of HIV- 1 transcription by WT ferroport in by afactor of 2, but did not have an effect on HIV- 1 transcrip-tion in the presence of ferroportin C32 6Y (Figure...
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Báo cáo y học: "Differences in HIV-related behaviors at Lugufu refugee camp and surrounding host villages, Tanzania" ppsx

... Lugufu camp. Younger respondents (15–20years) who reported transactional sex may have been veryyoung (5–10 years) when they arrived to Lugufu, becom-ing sexually active as they matured while ... experienced SGBV by anon-partner since the age of 15 years [19]. It is generallyaccepted that underreporting of this form of violence inquantitative research is far more likely than overreporting[20]. ... and the possibility that newcomers tohost villages were attracted by services and work opportu-nities offered by international organizations in the area.Although the majority of both refugee...
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Báo cáo y học: " Arginine deficiency augments inflammatory mediator production by airway epithelial cells in vitro" pps

... regulation of the production of inflammatory mediators, exemplified by key pro-inflammatory interleukin(IL)-6 and IL-8, by airway epi-thelial cells have shown that reduced levels of the essentialamino ... partially inhibit arginine uptake by NCI-H292 cells, we found no effect of poly-L-arginine onarginine uptake by NHBE cells. NCI-H292 cells are tumor- derived cells which typically display an enhanced ... stimulus of IL-6 and IL-8 production by NHBE cellsat these culture conditions, i.e. in the absence of FCS.Hyperresponsive IL-6 and IL-8 production by reduced levels of arginineIn a previous study...
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Báo cáo y học: "Inhibition of highly productive HIV-1 infection in T cells, primary human macrophages, microglia, and astrocytes by Sargassum fusiforme" pdf

... http://www.aidsrestherapy.com/content/3/1/15Page 8 of 12(page number not for citation purposes) by 81% on day 14 after infection. By comparison, virus inhibition by ddC was 72% on day 3, and thereafterremained ... M, Volsky JD: Repli-cation of different clones of human immunodeficiency virustype 1 in primary human fetal astrocytes: enhancment of viral gene expression by Nef. Journal NeuroVirology 1999,5:115-124.35. ... asdemonstrated by steadily increasing p24 production thatreached a peak on day 14 with 2,313 pg of p24/ml (notshown). Treatment with S. fusiforme inhibited this infec-tion by 75% on day 3, by over...
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Báo cáo y học: "Inhibition of core gene of HCV 3a genotype using synthetic and vector derived siRNAs" pot

... study, Csi27 of our study also showed the samelevel of inhibition upto 70% as by CsiRNA 1 used by Liu et al. The Csi352 also shares sequence homology toCsiRNA 3 but the difference in siRNA ... al.: Inhibition of core gene of HCV 3agenotype using synthetic and vector derived siRNAs. Virology Journal2010 7:318.Submit your next manuscript to BioMed Centraland take full advantage of: ... v ector offers an alternativefor intracellular delivery of siRNA for complete inhibition of viral gene expression and replication. To determinethis possibility, the activity of two siRNA expressionvectors...
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Báo cáo y học: " Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A" potx

... catalyzed by DHS, of an aminobutyl moiety (blue) from spermidine onto the side chain of eIF5A lysine-50, yielding deoxyhypusine (Dhp); and its subsequent hydroxylation, catalyzed by DOHH, yielding ... YP, Nemeroff M, Yan YP, Chen KY: Interaction of eukaryoticinitiation factor 5A with the human immunodeficiency virustype 1 Rev response element RNA and U6 snRNA requiresdeoxyhypusine or hypusine ... in HIV- 1replication. This protein contains the apparently unique amino acid hypusine that is formed by thepost-translational modification of a lysine residue catalyzed by deoxyhypusine synthase...
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Báo cáo y học: "Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal" pot

... nuclear import by the dissociation of IN-importin α interaction in HIV- infected cells. (A) H9 lymphocytes were infected by wild-type HIV- 1, and after infection half of the cells' lysate volume ... interaction as observed by the BiFC assay systemFigure 5IN interaction as observed by the BiFC assay system. EGY48 yeast cells were transformed using the lithium acetate method with plasmids ... modu-lated by coreceptor specificity defined by the V3 loop of gp120. J Virol 2000, 74:8358-8367.52. Cullen BR: Use of eukaryotic expression technology in thefunctional analysis of cloned genes....
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Báo cáo y học: " Inhibition of HIV-1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression" potx

... Retrovirology 2008, 5:8.4. Ye Y, De Leon J, Yokoyama N, Naidu Y, Camerini D: DBR1 siRNA inhibition of HIV- 1 replication. Retrovirology 2005, 2:63.5. Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman ... up-regulation of GliPR by HIV- 1 and the early significant inhibition of HIV- 1 replication mediated by knockdown of GliPR reveal GliPR as an important HIV- 1 dependency factor (HDF), which may be exploited ... theeffect of GliPR suppression by siRNA on HIV- 1 replication.Results: Induction of GliPR expression by HIV- 1 was confi rmed in P4-CCR5 cells. When GliPR was suppressed by siRNA, HIV- 1 replication...
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Báo cáo y học: "Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex" potx

... for inhibition of HIV Inhibition of HIV- 1 infectivity by non-cytotoxic concentra-tions of the P-TEFb inhibitors DRB, seliciclib and flavopiridolFigure 4 Inhibition of HIV- 1 infectivity by non-cytotoxic ... effectiveness of HAART arise as a result of theselection of random mutations generated by the lack of proofreading activity in HIV reverse transcriptase [17,19]and by G to A hypermutation that ... localization of the large Inhibition of HIV- 1 replication in MDMs by flavopiridolFigure 6 Inhibition of HIV- 1 replication in MDMs by flavopiridol. MDMs were isolated from healthy donors and...
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