Báo cáo y học: "The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix" pptx
Báo cáo y học: "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthriti" pptx
... embryos were obtained according to the reg- ulations of the Ethics Committee of the Medical Faculty of the University of Göttingen, Germany. The embryos were classi- fied as follows: three embryos ... appearance of the lateral aspects of a condyle of OA cartilage. Furthermore, these results were backed up by the quantitation of real-time RT- PCR results. Dynamic...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"
... USA 4. Chemical Biology Division, Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland 5. Division of Rheumatology, Department of Medicine, Pennsylvania ... in the DNA helix. These pathways were ex- amined by inhibition of the key proteins ataxia telan- giectasia related (ATR) and ataxia telangiecta- sia-mutated (ATM). The DNA-nic...
Ngày tải lên: 25/10/2012, 11:18
Tài liệu Báo cáo Y học: Ligand interactions and protein conformational changes of phosphopyridoxyl-labeled Escherichia coli phosphoenol pyruvate carboxykinase determined by fluorescence spectroscopy pdf
... points to changes in the dynamical properties of the local environment of the P-pyridoxyl group due to changes of the protein conformation induced by the binding of PEP or the ternary combination. Quenching ... caused by the ligand are easily sensed by the P-pyridoxyl chromophore. Figure 4 shows the modeled structure of the P-pyridoxyl-PEP carboxykinase in...
Ngày tải lên: 21/02/2014, 01:21
Báo cáo Y học: Spectroscopic characterization and ligand-binding properties of chlorite dismutase from the chlorate respiring bacterial strain GR-1 ppt
... co-ordinating the heme iron center of the enzyme. The UV/visible spectrum of the ferrous enzyme and EPR spectra of the ferric hydroxide and imidazole adducts are characteristic of a heme protein with an ... for the formation of a complex with hydrogen peroxide (Fig. 1, trace E). The EPR spectrum of the hydrogen peroxide complex, however, shows a decrease in the...
Ngày tải lên: 08/03/2014, 16:20
Báo cáo Y học: Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans doc
... amount of attention over the last few years, because they might help to explain the physiopathology of the disease, and may also provide therapeutic clues. Dystrobrevins form a family of proteins ... repeat of the second helix of Dyb-1 (amino acids 48 4 49 0) seems to be critical for proper Dys-1 binding to occur in vitro. Dys-1/Dyb)1 interactions in the yeast two hybri...
Ngày tải lên: 08/03/2014, 23:20
Báo cáo Y học: Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization pptx
... retained to day 15. Similarly, the band shift efficiency in the H 2 O 2 -cultures increased by 6.7-fold of the control in 15 days and reached the plateau of 10.7-fold activation on day 20 (Fig. 4A). Presence ... directly impair the energy-producing system of mitochondria, causing dysfunction of cellular redox control, which eventually leads to loss of the mitochondrial DN...
Ngày tải lên: 24/03/2014, 04:21
Báo cáo y học: "The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix" pptx
... purposes) Retrovirology Open Access Research The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix Kirsten Fraedrich, Birthe Müller and Ralph Grassmann* Address: ... explanation for the enhancement of CDK4 kinase activity induced by a synthetic N-terminal Tax peptide [39]. Furthermore, this may e...
Ngày tải lên: 13/08/2014, 09:21
Báo cáo y học: "Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis" pdf
... interests The authors declare that they have no competing interests. Authors' contributions HG was responsible for the majority of the practical work and the writing of the manuscript. The study ... significantly different from those of the wild-type mice when investigated in the CIA and CII anti- body-induced arthritis (CAIA) models. Apparently, the micro- struct...
Ngày tải lên: 09/08/2014, 13:22
Báo cáo y học: "Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort" pot
... JS: Benefit of very early referral and very early therapy with dis- ease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis. Rheumatology (Oxford) 20 04, 43 :906-9 14. 34. Landewe ... (50.8) DAS28 4. 01 (1. 34) 3.90 (3.06 -4. 82) HAQ (0-3) 0. 84 (0.67) 0.75 (0.25-1.25) SF-36: PCS 33 .4 (10.8) 32.8 (25.1 -40 .4) MCS 48 .6 (11 .4) 50 .4 (40 .1-57 .4) Ever smo...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: " Allergic enterocolitis and protein-losing enteropathy as the presentations of manganese leak from an ingested disk battery: A case report" pps
... and pathology. Neurotoxicology 1999, 20(2–3):227-238. 4. Takazawa K, Ishikawa N, Miyagawa H, Yamamoto T, Hariya A, Dohi S: Metal allergy to stainless steel wire after coronary artery bypass grafting. ... by the Mn leak from a retained disk battery; she was completely asymptomatic before battery inges- tion with normal albumin levels and eosinophil counts before battery removal. Additionall...
Ngày tải lên: 11/08/2014, 21:22