Báo cáo y học: "The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix" pptx
Báo cáo y học: "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthriti" pptx
... embryos were obtained according to the reg-ulations of the Ethics Committee of the Medical Faculty of the University of Göttingen, Germany. The embryos were classi-fied as follows: three embryos ... appearance of the lateralaspects of a condyle of OA cartilage. Furthermore, theseresults were backed up by the quantitation of real-time RT-PCR results. Dynamic loading increases the expression of COMP, ... earlier investigations on the pathogenesis of OA, we areaware of two different cell types found in the late stages of the disease [33, 34] . Type 1 cells are the diseased chondrocytesfound in regions...
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Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"
... USA 4. Chemical Biology Division, Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland 5. Division of Rheumatology, Department of Medicine, Pennsylvania ... in the DNA helix. These pathways were ex-amined by inhibition of the key proteins ataxia telan-giectasia related (ATR) and ataxia telangiecta-sia-mutated (ATM). The DNA-nicking activity that ... activate the single-strand break DNA repair pathway if applied to host cell DNA. This pathway was investigated by studying the activity of Poly(ADP-ribose)Polymerase (PARP), the protein which...
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Tài liệu Báo cáo Y học: Ligand interactions and protein conformational changes of phosphopyridoxyl-labeled Escherichia coli phosphoenol pyruvate carboxykinase determined by fluorescence spectroscopy pdf
... points to changes in the dynamicalproperties of the local environment of the P-pyridoxylgroup due to changes of the protein conformation inducedby the binding of PEP or the ternary combination.Quenching ... caused by the ligand are easilysensed by the P-pyridoxyl chromophore. Figure 4 shows the modeled structure of the P-pyridoxyl-PEP carboxykinase in the free and substrate bound conformations. In the ... decrease of kq, asexpected from the hidden of the P-pyridoxyl group in the protein matrix upon ligand binding (Fig. 4) . However, the magnitude of these changes are dependent on the nature of the...
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Báo cáo Y học: Spectroscopic characterization and ligand-binding properties of chlorite dismutase from the chlorate respiring bacterial strain GR-1 ppt
... co-ordinating the hemeiron center of the enzyme. The UV/visible spectrum of the ferrous enzyme and EPR spectra of the ferric hydroxide andimidazole adducts are characteristic of a heme protein withan ... for the formation of acomplex with hydrogen peroxide (Fig. 1, trace E). The EPRspectrum of the hydrogen peroxide complex, however,shows a decrease in the high-spin signal of the enzyme and the ... the enzyme from GR-1 [4] . However, the existence of a second high-spin species, which we have designated the ÔbroadÕ signal, has not been reported previously. The nature of the multiplicity of...
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Báo cáo Y học: Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans doc
... amount of attention over the last few years,because they might help to explain the physiopathology of the disease, and may also provide therapeutic clues.Dystrobrevins form a family of proteins ... repeat of the second helix of Dyb-1 (amino acids 48 4 49 0) seems to be critical for properDys-1 binding to occur in vitro.Dys-1/Dyb)1 interactions in the yeast two hybrid assayNext, we t ested the ... ested the ab ilit y of t he various forms of Dyb-1 t ointeract with Dys-1 in a two-hybrid assay. The Dyb-1control and mutant clones w ere fused to the activation domain of the Gal4 yeast transcription...
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Báo cáo Y học: Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization pptx
... retained to day 15. Similarly, the band shift efficiency in the H2O2-cultures increased by6.7-fold of the control in 15 days and reached the plateau of 10.7-fold activation on day 20 (Fig. 4A). Presence ... directly impair the energy-producing system of mitochondria, causing dysfunction of cellular redox control,which eventually leads to loss of the mitochondrial DNAintegrity. The mechanism of cellular ... 4A). Presence of the NF-jB p65 protein in the shifted complex was confirmed bydetection of a super-shift band using a the p65 antibodyeither in the AZT-treated cells (day 15) or in the H2O2-treated...
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Báo cáo y học: "The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix" pptx
... purposes)RetrovirologyOpen AccessResearch The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helixKirsten Fraedrich, Birthe Müller and Ralph Grassmann*Address: ... explanation for the enhancement of CDK4 kinase activity induced by asynthetic N-terminal Tax peptide [39]. Furthermore, thismay explain the increased affinity of cyclin to CDK in the presence of Tax [36]. ... the CDK'scyclin D2 binding domain. Its rotation during the activa-tion of CDK4 is required to unblock the catalytic cleft of the kinase [44 ]. Binding of Tax to this region may influ-ence...
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Báo cáo y học: "Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis" pdf
... interests The authors declare that they have no competing interests.Authors' contributionsHG was responsible for the majority of the practical work and the writing of the manuscript. The study ... significantly different from those of the wild-type mice when investigated in the CIA and CII anti-body-induced arthritis (CAIA) models. Apparently, the micro-structure of the cartilage of collagen ... to compare the onset day and the severity of arthritis developed among the female mice.Cartilage oligomeric matrix protein deficiency did not alter collagen II-specific antibody synthesisAntibodies...
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Báo cáo y học: "Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort" pot
... JS:Benefit of very early referral and very early therapy with dis-ease-modifying anti-rheumatic drugs in patients with earlyrheumatoid arthritis. Rheumatology (Oxford) 20 04, 43 :906-9 14. 34. Landewe ... (50.8)DAS28 4. 01 (1. 34) 3.90 (3.06 -4. 82)HAQ (0-3) 0. 84 (0.67) 0.75 (0.25-1.25)SF-36:PCS 33 .4 (10.8) 32.8 (25.1 -40 .4) MCS 48 .6 (11 .4) 50 .4 (40 .1-57 .4) Ever smoker 236 (61.5)Number of patients ... (20).Frequency of outcomesA total of 146 patients had one or more of the assessed out-comes at one year. The distribution of patients by outcome isdepicted in Figure 1. Forty patients (10 .4% ) had...
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Báo cáo y học: " Allergic enterocolitis and protein-losing enteropathy as the presentations of manganese leak from an ingested disk battery: A case report" pps
... and pathology. Neurotoxicology 1999,20(2–3):227-238. 4. Takazawa K, Ishikawa N, Miyagawa H, Yamamoto T, Hariya A, DohiS: Metal allergy to stainless steel wire after coronary arterybypass grafting. ... by the Mn leak from a retained disk battery;she was completely asymptomatic before battery inges-tion with normal albumin levels and eosinophil countsbefore battery removal. Additionally, there ... consent was obtained from the parentfor publication of this case report, as the child was aminor. A copy of the written consent is available forreview by the Editor-in-Chief of this journal.References1....
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