Báo cáo y học: "Role of viral evolutionary rate in HIV-1 disease progression in a linked cohort" pptx

... that therapy may have partially influenced viral evolution of HIV-1 strains in cohort patients, it is difficult to assess contribution of individual drugs in affecting viral evolutionary rates. ... individuals, which is defined invariably by increasing plasma viral loads and concomitant decline in the CD4 + T cell counts. A small but rare subset of chroni- cally-infec...

Ngày tải lên: 13/08/2014, 09:21

... citation purposes) Determination of plasma and cell-associated viral loadsFigure 1 Determination of plasma and cell-associated viral loads. The mean plasma viral load levels (A) and mean cell-associated ... significance only at week 28. A neonatal macaque study showed that passively trans- ferred non-nAbs did not protect the animals against oral challenge with SIVmac251 indicating...

Ngày tải lên: 12/08/2014, 23:21

... VS have been identified [18], it remains unclear which domains of viral Env and Gag proteins are opera- tional in mediating transport and functional accumula- tion of HIV-1 structural proteins ... Lodge R, Lalonde JP, Lemay G, Cohen EA: The membrane-proximal intracytoplasmic tyrosine residue of HIV-1 envelope glycoprotein is critical for basolateral targeting of viral budd...

Ngày tải lên: 12/08/2014, 23:23

... Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nis hida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, ... sug- gesting that soy protein intake stimulates skeletal muscle fatty acid oxidation by activating PPAR path- ways leading to reduced accumulation of body fat. Soy protein may reduce...

Ngày tải lên: 31/10/2012, 14:59

... evolution of cyanobacterial and plant plastocyanins. Keywords: cyanobacteria; electron transfer; photosystem I; plastocyanin; weak interaction. Electron-transfer chains like that of oxygenic photosyn- thesis ... Herva ´ s, M., Navarro, J .A. , Dı ´ az, A. & De la Rosa, M .A. (1996) A comparative thermodynamic analysis by laser-flash absorption spectroscopy of photosystem I reducti...

Ngày tải lên: 21/02/2014, 01:21

... chromatography (Shimadzu, Kyoto, Japan; GC-14B) equipped with a hydrogen flame- ionization detector. Arachidic acid was used as an internal standard. The fatty acid methyl esters were separated ... Tokyo, Japan; 3 Department of Integrated Biosciences, Graduate School of Frontier Sciences, the University of Tokyo, Kashiwa, Chiba, Japan The physiological role of sulfoquinovosyl diacylg...

Ngày tải lên: 22/02/2014, 04:20

... report in which docosahexaenoic acid, a polyunsaturated fatty acid, affects the calcium channels in an albumin reversible manner [42]. The present study demonstrates that AA facilitates TG- induced ... shown). AA interacts extracellularly In order to assess whether AA acts extracellularly during Ca 2+ in ux, we used the fatty acid free BSA at a final concentration of 0.2% (w/v) as...

Ngày tải lên: 08/03/2014, 09:20

... Mayoral, T., Medina, M., Sanz-Aparicio, J., Go ´ mez-Moreno, C. & Hermoso, J .A. (2000) Structural basis of the catalytic role of Glu301 in Anabaena ferredoxin-NADP + reductase revealed by X-ray ... E ox/sq and E sq/rd . Previous characterization of the reactivity of this E30 1A FNR mutant in complex formation and ET to its substrates had already indicated that the lack of...

Ngày tải lên: 08/03/2014, 23:20

... SDS/PAGE analysis of a selection of mutant oxaloacetate decarboxylases synthesized in E. coli and purified by avidin–Sepharose chromatography. Mutations in OadB are indicated. WT, wild-type enzyme; ... of Y2 29, which subsequently can be replaced by a Na + -ion again, initiating the decarboxylation of the newly bound carboxybiotin. This interpretation can explain why in the...

Ngày tải lên: 08/03/2014, 23:20

... flavin position is also marginally altered by the substitution of Y2 38 (Table 2). Steady-state and rapid reaction kinetics with D -alanine The ability of the Y2 38 mutants to catalyse D -alanine/ oxygen ... substrates with large, hydrophobic side chains (such as cephalospo- rin C and D -phenylalanine), as well as for a small and polar aminoacidsuchas D -serine. The Y2 38 mutants have...

Ngày tải lên: 17/03/2014, 17:20